最新刊期
卷 0 ， 期 0 ， 2020
- 摘要：? Cerebral blood flow perfusion SPECT imaging with 99m Tc-ECD were studied in 48 patients of cerebral trauma, among them 41 cases also performed CT within 2 weeks of SPECT imaging. The results showed that the detection rate of SPECT and CT for mild, moderate and severe cerebral trauma were 60%（6/10）, 90%（10/11）, 100%（9/9） and 10%（1/10）, 60%（6/10）, 100%（9/9） respectively. Besides, detection rate of SPECT and CT in cerebral trauma symdrome and sequela groups were 80%, 90% and 25%, 71% respectively. Apparently, the sensitivity of SPECT was higher than CT but not the specificity. However, the more earlier the appearence of the lesion site, the more sites and extent of the lesion will be find in SPECT than CT. It was concluded that through the combined use of these two technologies, the pathophysiologic changes of cerebral trauma can be accurately reflected, their sensitivity and specificity further elevated, thereby have more significance for therapeutic guiding.关键词：Cerebral trauma;Brain;SPECT
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发布时间：2021-04-09 - 摘要：? Using radioimmunoassay to determine serum BGP, PTH and CT, this paper showed that there are various changes of level of BGP, PTH, CT with respect to osteoporosis of different etiology. It suggested that the combined determination has certain reference value in clinical diagnosis, disease staging and treatment of the aged osteoporosis.关键词：BGP;PTH;CT;The aged;Osteoporosis
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发布时间：2021-04-09 - 摘要：? In this paper, apoptosis in human acute lymphoblastic leukemia cell line Molt-4 cell and macrophage cell line ANA-1 cell were induced by fission product 147 Pm. The cumulative absorption dose of 147 Pm in cultural cells through different periods were estimated. The morphological changes in Molt-4 and ANA-1 cells were observed by fluorescence microscopy and microautoradiographic tracing. Molt-4 and ANA-1 cells internally irradiated by 147 Pm were found, displayed a significant nuclear fragmentation and a marked pyknosis in immune cell’s nuclei, as will as DNA chain fragmentation and apoptotic bodies formation. The microautoradiographic study showed that 147 Pm could penetrate cell membrane and displayed membrane-seeking condensation in cells. At the same time, the membrane-bounded apoptotic bodies were observed. Experimental results in recent study provide evidence that Molt-4 and ANA-1 immune cells undergo apoptosis while internally irradiated with 147 Pm.关键词：Fluorescence microscopy;Microautoradiography;147 Pm;Molt-4 cell;ANA-1 cell;Apoptosis
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发布时间：2021-04-09 - 摘要：? In order to decrease the high liver uptake of avidin（Av）, and elongate its retention in blood, Av is modified with some chemical groups. The tissue distributions in mice of Av, sucAv, octoAv, octoAvsuc, streptavidin（SA）, all of which are labelled with 125 I, are studied at 3,6,16,26h post injection. It is shown that 125 IsucAv lowers the uptake in liver, kidney and spleen, and 125 IoctoAv has lower uptake than 125 ISA, but the radioactivity in liver is high; the kidney concentration of 125 IoctoAvsuc is the highest at first, however, its metabolism in kidney is quicker than 125 ISA. The blood levels of 125 IsucAv, 125 IoctoAv, 125 IoctoAvsuc, are lower than that of 125 IAv.关键词：Avidin;Streptavidin;125 I labelling;Biological distribution
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发布时间：2021-04-09 - 摘要：? A method for labelling antibodies （poly or monoclonal） indirectly with 99m Tc is studied The various factors that effect the labelling yield are discussed The result shows that labelling yields are more than 95% Imaging of rabbit inflammatory model, dog thrombus model and test of immune pathology show that the labelling antibody has good bioactivity
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发布时间：2021-04-09 - 摘要：? The therapeutic effect and safety of De Ke Shi（DKS） in the treatment of 126 cases of active rheumatoid patients were observed The clinical manifestation and laboratory eamination before and after treatment were demonstrated In some patient comparative study were done with control drug——Lei Gong Teng（LGT） The results showed that the overall effective rate was 857%, better than LGT The effectiveness of relieving pain, diminishing swelling, increasing immune function etc was significant It was most effective in improving morning stiffness, limitation of articular function and decreasing ESR It was concluded that DKS was safe, no significant adverse action and worthy clinical using关键词：De Ke Shi;Rheumatoid arthritis;Treatment
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发布时间：2021-04-09 - 摘要：fter temporary occlusion of left hepatic vein, hepatic arterial embolization （HAE） were performed with 131 I-lipiodol, it can improve the effectiveness of HAE in treatment of hepatocillular carcinoma Using the pig as a model, during the course of embolization of the left hepatic artery with 131I-lipiodol, temporary occlusion of the left hepatic vein was done in the experimental group Lipiodol was labelled with 131I using exchanged reaction method The labelled rate was 95% The lung/liver radioactive ratio, radioactive distribution and the condition of radioactive decay in body was obtained by the SPECT imaging after operation The radioactive ratio of the lung/liver in experimental group was lower than that in control group （<005） on the 1st and 3rd days after operation and has no significant difference on the 5th, 7th and 14th days （<005） The effective half-life of 131I-lipiodol was 453 day （median） The pathological change of experimental group was more severe than control group expressing spotty infarct, fibrinoid necrosis, coagulation necrosis etc The result of experiment showed that this method is safe, effective and can tentatively be used clinically关键词：Radioiodine;Hepatic arterial embolization;Animal experimentals;131 I-lipiodol
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发布时间：2021-04-09 - 摘要：? Factors affecting the labelling yield and optimal labelling procedures of 186 Re labelled HEDP are reported Results showed that after intravenous injection of 186 Re-HEDP, a greater concentration was demonstrated in bones, time of peak level being 2h Two hours after injection, 186 Re-HEDP distribution of %ID/bone was 3248±104; that of 99m Tc-HEDP was 1781±278; 153 Sm-EDTMP was 222±427 Rabbit bone scan showed clear imaging in the skeletal system Twenty four hours urine excretion was 69±15 Blood clearance was relativity rapid conforming to two phase distribution Thus 186 Re-HEDP can be used in the treatment of bone metastasis and possibility exist that it will soon be available as kit in the near future关键词：186 Re;HEDP;Nuclear treatment
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发布时间：2021-04-09 - 摘要：? The radiochemical purity （RCP） of 99m TcN（DDC）2 （DDC: N,N-diethyl- dithiocarbamate） prepared by using the intermediate 99m TcN was evaluated by TLC to be 90% The partition coefficient at pH 74 was determined to be 1427 Myocardial uptakes of mice at 5, 30 and 60min post iv injection were 264, 106 and 059%ID, and brain corresponding uptakes were 130, 056 and 032%ID, respectively
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发布时间：2021-04-09 - 摘要：n order to treat the patients with inflammatory snovial diseases, HA particles was labelled with 166 Ho by EDTMPThe radiolabelling efficiency was more than 95%; size of particle was mainly at the range of 2—5μm; in vitro study showed that loss ratio of 166 Ho-EDTMP-HA particle incubating 72h in the nomal saline solution and 1% BSA solution was less than 2%In vivo biodistribution and extra articular leakage were in vestigated following injection of 166 Ho-EDTMP-HA into knees of normal rabbitsThe eperimental results found that etra articular leakage of 166 Ho-EDTMP-HA was 032% at 48h postinjection, most of 166 Ho that leaked from the knee joint was ecreted in urine关键词：Radiation synovectomy;Hydroxyapatite（HA）;166Ho-EDTMP-HA
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发布时间：2021-04-09 - 摘要：? A method different from literature has been developed for the preparation of ω-p-iodophenyl pentadanoic acid（IPPA） The synthesis and physical properties of IPPA is described It is characterized by IR, 1HNMR, elementary analysis and MS 125 I-IPPA can be easily prepared by two methods: direct labelling and iodo-exchange labelling, the yields of labelling are 80% and 65% respectively confirmed by TLC and HPLC The radiochemical purity are higher than 95% after extraction关键词：ω-p-iodophenyl pentadanoic acid;Fatty acid;Synthsis;125 I-radioiodine labelling;125 I-IPPA
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发布时间：2021-04-09 - 摘要：? 211At-Te colloid with a diameter of 3—8μm was prepared. The biodistribution of 211At-Te colloid and free 211 At in mice were measured and compared. The stability of 211 At-Te colloid was confirmed, but under in vivo conditions some degree of deastatination had occured. The therapeutic effect of 211 At-Te colloid for Ehrlich ascites tumors in mice was investigated. The result showed that tumor can be cured in all mice that received a single intraperitoneal injection of 1 or 2 MBq 211 At-Te colloid, without causing undue toxic side effects to normal tissues. Below these curative doses, the survival time of mice was prolonged. The mice died away due to toxicity after injection of doses over 3 MBq.关键词：211 At;Tellurium;Radiocolloid;Biodistribution;Endoradiotherapy;Ehrlich ascites tumors
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发布时间：2021-04-09 - 摘要：? To investigate the relation between GMP-140 with the progress and mechanism of cerebrovascular diseases, the level of GMP-140 in both platelet and plasma in 76 cases of cerebrovascular diseases and 35 normal controls were determined by radioimmunoassay （RIA）. Results showed that the level of GMP-140 in both platelet and plasma of cerebrovascular diseases were remarkably higher than that in normal controls（P<0.001）; significant difference also existed in both platelet and plasma GMP-140 between cerebral hemorrhage, vertebral-basilar artery blood supply insufficiency, and normal controls（P<0.01）; significant difference of the level of both platelet and plasma GMP-140 also occured before and after a three week thrombolytic therapy. Morever, positive correlation was found between platelet and plasma GMP-140 level （0.76, 0.49, 0.20）; No difference existed in platelet count between cerebrovascular diseases and normal controls（P>0.05）. It was concluded that the progress, develpment, and prognosis of cerebrovascular diseases is strongly related to the platelet function and the level of GMP-140.关键词：Cerebrovascular diseased;Platelet;Membrane proteins;Radioimmunoassay
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发布时间：2021-04-09 - 摘要：? Preparation of 153 Sm-Cl2MDP and stability in vitro were investigated, and animal test and blood clearance of 153 Sm-Cl2MDP were performed in the paper The eperimental result showed that the skeletal uptake of 153 Sm-Cl2MDP was high, the blood clearance was slower than 153 Sm-EDMDP , and the liver uptake was 10 times that of 153 Sm-EDMDP关键词：153Sm-Cl2MDP;Biodistribution in vivo;Blood clearance
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发布时间：2021-04-09 - 摘要：he purpose of this paper is to evaluate acute ischemia and reperfusion in canine models by serial 99m Tc-MIBI myocardial SPECT studies. In 24 dogs, myocardial ischemia was induced by dilated balloon inserted in LAD or LCX, followed by reperfusion at 1h （GroupⅠ）, 4h （Group Ⅱ） later, and permanent ischemia by copper coil（Group Ⅲ）. The first and second imaging was taken after ischemia and after reperfusion. The 3rd, 4th and 5th SPECT were at 7, 14 and 28 days later. Defect fraction（DF）, and ischemic fraction（IF） was obtained from the Bull′s-eye images. The first DFs in all 3 groups correlated well with the myocardium at risk（IF） measured by pathological study. DF in group Ⅰ decreased censistently since the second SPECT, in Group Ⅱ DF had some decrease, while in Group Ⅲ no decrease of DF was measured. The SF in all animals showed the same trend. The last DF was correlated with the real size of infarct foci（NF） determined by TTC staining by pathological study. 99m Tc-MIBI SPECT was sensitive and accurate in revealing myocardial damage after acute ischemia and its response to reperfusion. The first（before）, seconed（right after）, and the last SPECT（4 weeks after reperfusion） were the most informative and clinically useful.关键词：99m Tc-MIBI;Myocardial ischemia;Myocardial reperfusion;Myocardial stunning
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发布时间：2021-04-09 - 摘要：? Myocardial perfusion imaging in normal and acute myocardial infarction（AMI） model dogs with 99m Tc-Teboroxime was reported The experiment in normal dogs showed that 99m Tc-Teboroxime has a high extraction fraction and rapid myocardial washout After injection the myocardium uptaked immediately The heart/liver activity ratio is 436 The myocardial activity decreased to half of its peak value at 612min The lung uptake is less The heart/lung activity ratio is 212 at 1 min and 20 at 2 min respectively The ischemic myocardium in AMI models uptaked 99m Tc-Teboroxime less and washout slower The peak value in ischemic area only reached 06 of normal myocardium The myocardium acticity at 612min was 086 times that of the peak value Finally the defects were seen clearly in the two myocardial infarction canine models with a rapid planar imaging关键词：99mTc-Teboroxime;Myocardial imaging
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发布时间：2021-04-09
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