Preparation of 153  Sm-Cl2MDP and preliminary animal test

Bai Hongsheng   Du Jin   Cheng Zhen   Fan HongqiangWang Fan   Chen Daming   Jin Xiaohai

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Preparation of 153 Sm-Cl2MDP and preliminary animal test

更新时间：2021-04-09

- Preparation of 153 Sm-Cl2MDP and preliminary animal test
- NUCLEAR TECHNIQUES Issue 11, (1997)
- 作者机构：
  
  中国原子能科学研究院同位素所
- 作者简介：
- 基金信息：
- DOI：
  CLC： R446.11
- Published：01 November 1997
- 稿件说明：
移动端阅览
[1]白红升,杜进,程震,樊红强,王凡,陈大明,金小海.~(153)Sm-骨膦(Cl_2MDP)的制备和初步动物实验[J].核技术,1997(11):59-61.

Bai Hongsheng Du Jin Cheng Zhen Fan HongqiangWang Fan Chen Daming Jin Xiaohai. Preparation of 153 Sm-Cl2MDP and preliminary animal test[J]. Nuclear techniques, 1997, (11).
[1]白红升,杜进,程震,樊红强,王凡,陈大明,金小海.~(153)Sm-骨膦(Cl_2MDP)的制备和初步动物实验[J].核技术,1997(11):59-61. DOI：

Bai Hongsheng Du Jin Cheng Zhen Fan HongqiangWang Fan Chen Daming Jin Xiaohai. Preparation of 153 Sm-Cl2MDP and preliminary animal test[J]. Nuclear techniques, 1997, (11). DOI：

摘要

研究了５３Ｓｍ－Ｃｌ２ＭＤＰ的制备和体外稳定性，对其在动物体内分布和血液清除进行评价，并与１５３Ｓｍ－ＥＤＴＭＰ进行比较。实验结果表明１５３Ｓｍ－Ｃｌ２ＭＤＰ具有良好的体外稳定性，骨中摄取量高，血液清除较快；与１５３Ｓｍ－ＥＤＴＭＰ比较，血液清除慢，但肝脏摄取量比１５３Ｓｍ－ＥＤＴＭＰ高１０倍，故１５３Ｓｍ－Ｃｌ２ＭＤＰ不是一种理想的骨肿瘤治疗剂。

Abstract

? Preparation of 153 Sm-Cl2MDP and stability in vitro were investigated

and animal test and blood clearance of 153 Sm-Cl2MDP were performed in the paper The eperimental result showed that the skeletal uptake of 153 Sm-Cl2MDP was high

the blood clearance was slower than 153 Sm-EDMDP

and the liver uptake was 10 times that of 153 Sm-EDMDP

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