An animal study on 186  Re labelled HEDP

Zhu Ruisen   Zhu Jun   Zhu Jifang   Lu Haikui   Jin Changqing   Ma Jixiao

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An animal study on 186 Re labelled HEDP

更新时间：2021-04-09

- An animal study on 186 Re labelled HEDP
- NUCLEAR TECHNIQUES Issue 11, (1997)
- 作者机构：
  
  上海市第六人民医院
- 作者简介：
- 基金信息：
- DOI：
  CLC： Q95-33
- Published：01 November 1997
- 稿件说明：
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[1]朱瑞森,朱继芳,陆汉魁,金常青,马寄晓.~(186)Re 标记 HEDP 的动物实验研究[J].核技术,1997(11):39-42.

Zhu Ruisen Zhu Jun Zhu Jifang Lu Haikui Jin Changqing Ma Jixiao. An animal study on 186 Re labelled HEDP[J]. Nuclear techniques, 1997, (11).
[1]朱瑞森,朱继芳,陆汉魁,金常青,马寄晓.~(186)Re 标记 HEDP 的动物实验研究[J].核技术,1997(11):39-42. DOI：

Zhu Ruisen Zhu Jun Zhu Jifang Lu Haikui Jin Changqing Ma Jixiao. An animal study on 186 Re labelled HEDP[J]. Nuclear techniques, 1997, (11). DOI：

摘要

研究了１８６Ｒｅ标记ＨＥＤＰ的反应动力学、标记的影响因素、最佳标记方法。实验结果显示：１８６Ｒｅ－ＨＥＤＰ静注后绝大部分放射性聚积于骨胳中，并且于２ｈ时达到高峰（３２．４８±１．０４ＩＤ％／ｇ），而９９ｍＴｃ－ＨＥＤＰ为１７．８１±２．７８ＩＤ％／ｇ，１５３Ｓｍ－ＥＤＴＭＰ为２２．２０±４．２７ＩＤ％／ｇ，前者均比后二者高。静注家兔ＥＣＴ显像，骨胳显影清晰，２４ｈ内尿排泄率为６９±１５ＩＤ％。血液清除较快，符合二项分布。提示１８６Ｒｅ－ＨＥＤＰ有治疗骨转移的可能并有可能研制成药盒供应。

Abstract

? Factors affecting the labelling yield and optimal labelling procedures of 186 Re labelled HEDP are reported Results showed that after intravenous injection of 186 Re-HEDP

a greater concentration was demonstrated in bones

time of peak level being 2h Two hours after injection

186 Re-HEDP distribution of %ID/bone was 3248±104; that of 99m Tc-HEDP was 1781±278; 153 Sm-EDTMP was 222±427 Rabbit bone scan showed clear imaging in the skeletal system Twenty four hours urine excretion was 69±15 Blood clearance was relativity rapid conforming to two phase distribution Thus 186 Re-HEDP can be used in the treatment of bone metastasis and possibility exist that it will soon be available as kit in the near future

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