The biological distributions in mice of the 125  I labelled Av, Av derivants and SA

Chen Lai    Zhou Zhentang    Zhuang Daoling    Bao Borong

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The biological distributions in mice of the 125 I labelled Av, Av derivants and SA

更新时间：2021-04-09

- The biological distributions in mice of the 125 I labelled Av, Av derivants and SA
- NUCLEAR TECHNIQUES Issue 11, (1997)
- 作者机构：
  
  中国科学院上海原子核研究所
- 作者简介：
- 基金信息：
- DOI：
  CLC： R978.12
- Published：01 November 1997
- 稿件说明：
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[1]陈来,周桢堂,庄道玲,包伯荣.~(125)I 标记的亲和素及其衍生物在小鼠体内的生物分布[J].核技术,1997(11):36-38.

Chen Lai Zhou Zhentang Zhuang Daoling Bao Borong. The biological distributions in mice of the 125 I labelled Av, Av derivants and SA[J]. Nuclear techniques, 1997, (11).
[1]陈来,周桢堂,庄道玲,包伯荣.~(125)I 标记的亲和素及其衍生物在小鼠体内的生物分布[J].核技术,1997(11):36-38. DOI：

Chen Lai Zhou Zhentang Zhuang Daoling Bao Borong. The biological distributions in mice of the 125 I labelled Av, Av derivants and SA[J]. Nuclear techniques, 1997, (11). DOI：

摘要

为了降低鸟亲和素（Ａｖ）的高肝摄取，延长Ａｖ在血液中的滞留时间，对Ａｖ进行化学修饰。修饰后的Ａｖ衍生物用１２５Ｉ标记示踪，观察小鼠体内生物分布。结果表明，Ａｖ衍生物１２５Ｉ－ｓｕｃ－Ａｖ减少肝、肾、脾中摄取最佳；衍生物１２５Ｉ－ｏｃｔｏ－Ａｖ在肾中摄取较链霉亲和素低，而在肝中仍有较高放射性浓集；衍生物１２５Ｉ－ｏｃｔｏ－Ａｖ－ｓｕｃ的肾摄取虽较高，但代谢较１２５Ｉ－ＳＡ快，然而肝摄取没有明显降低。三种Ａｖ衍生物的血中放射性都低于Ａｖ。

Abstract

? In order to decrease the high liver uptake of avidin（Av）

and elongate its retention in blood

Av is modified with some chemical groups. The tissue distributions in mice of Av

sucAv

octoAv

octoAvsuc

streptavidin（SA）

all of which are labelled with 125 I

are studied at 3

26h post injection. It is shown that 125 IsucAv lowers the uptake in liver

kidney and spleen

and 125 IoctoAv has lower uptake than 125 ISA

but the radioactivity in liver is high; the kidney concentration of 125 IoctoAvsuc is the highest at first

however

its metabolism in kidney is quicker than 125 ISA. The blood levels of 125 IsucAv

125 IoctoAv

125 IoctoAvsuc

are lower than that of 125 IAv.

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Chen Lai Zhou Zhentang Zhuang Daoling Bao Borong

周桢堂

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Related Institution

Shanghai Institute of Applied Physics, Chinese Academy of Sciences

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