Preparation and biodistribution of 99m  TcN（DDC）2

Fang Ping   Zhou Xiang   Wu Chunying   Chen Zhengping   Ji Shuren

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Preparation and biodistribution of 99m TcN（DDC）2

更新时间：2021-04-09

- Preparation and biodistribution of 99m TcN（DDC）2
- NUCLEAR TECHNIQUES Issue 11, (1997)
- 作者机构：
  
  江苏省原子医学研究所
- 作者简介：
- 基金信息：
- DOI：
  CLC： R446.11
- Published：01 November 1997
- 稿件说明：
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[1]方平,周翔,吴春英,陈正平,纪书仁.~(99m)TcN(DDC)_2 的制备及生物分布[J].核技术,1997(11):62-64.

Fang Ping Zhou Xiang Wu Chunying Chen Zhengping Ji Shuren. Preparation and biodistribution of 99m TcN（DDC）2[J]. Nuclear techniques, 1997, (11).
[1]方平,周翔,吴春英,陈正平,纪书仁.~(99m)TcN(DDC)_2 的制备及生物分布[J].核技术,1997(11):62-64. DOI：

Fang Ping Zhou Xiang Wu Chunying Chen Zhengping Ji Shuren. Preparation and biodistribution of 99m TcN（DDC）2[J]. Nuclear techniques, 1997, (11). DOI：

摘要

用９９ｍＴｃＮ中间体制得的９９ｍＴｃＮ（ＤＤＣ）２经ＴＬＣ检测放化纯及标记率均大于９０％。标记物在ｐＨ７．４时的分配系数是１４２７。小鼠体内分布研究表明５、３０、６０ｍｉｎ时的心肌摄取分别为２．６４、１．０６、０．５９％ＩＤ，脑摄取分别为１．３０、０．５６、０．３２％ＩＤ。

Abstract

? The radiochemical purity （RCP） of 99m TcN（DDC）2 （DDC: N

N-diethyl- dithiocarbamate） prepared by using the intermediate 99m TcN was evaluated by TLC to be 90% The partition coefficient at pH 74 was determined to be 1427 Myocardial uptakes of mice at 5

30 and 60min post iv injection were 264

106 and 059%ID

and brain corresponding uptakes were 130

056 and 032%ID

respectively

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