Therapeutic agent for radiation synovectomy preparation of 166  Ho-EDTMP-HA

Bai Hongsheng  Jin Xiaohai   Du Jin  Wang FanCen Daming  Fan Hongqiang  Cheng Zhenh

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Therapeutic agent for radiation synovectomy preparation of 166 Ho-EDTMP-HA

更新时间：2021-04-09

- Therapeutic agent for radiation synovectomy preparation of 166 Ho-EDTMP-HA
- NUCLEAR TECHNIQUES Issue 11, (1997)
- 作者机构：
  
  中国原子能科学研究院同位素所
- 作者简介：
- 基金信息：
- DOI：
  CLC： R605
- Published：01 November 1997
- 稿件说明：
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[1]白红升,金小海,杜进,王凡,陈大明,樊红强,程震.放射性滑膜切除治疗剂 ~(166)Ho-EDTMP-HA 的制备[J].核技术,1997(11):51-55.

Bai Hongsheng Jin Xiaohai Du Jin Wang FanCen Daming Fan Hongqiang Cheng Zhenh. Therapeutic agent for radiation synovectomy preparation of 166 Ho-EDTMP-HA[J]. Nuclear techniques, 1997, (11).
[1]白红升,金小海,杜进,王凡,陈大明,樊红强,程震.放射性滑膜切除治疗剂 ~(166)Ho-EDTMP-HA 的制备[J].核技术,1997(11):51-55. DOI：

Bai Hongsheng Jin Xiaohai Du Jin Wang FanCen Daming Fan Hongqiang Cheng Zhenh. Therapeutic agent for radiation synovectomy preparation of 166 Ho-EDTMP-HA[J]. Nuclear techniques, 1997, (11). DOI：

摘要

１６６Ｈｏ通过两步法用ＥＤＴＭＰ对ＨＡ颗粒进行标记，其标记率大于９５％；颗粒大小为２—５μｍ；吸附容量为５ｍｇＨｏ／ｇＨＡ。体外稳定性表明标记物在生理盐水和１％牛血清蛋白溶液中放置７２ｈ，１６６Ｈｏ的脱落率小于２％。１６６Ｈｏ－ＥＤＴＭＰ－ＨＡ注射到正常兔子的关节腔内来研究标记物的体内分布情况和关节外的泄漏，实验结果表明１６６Ｈｏ－ＥＤＴＭＰ－ＨＡ注射到正常兔子的关节腔内来研究标记物的体内分布情况和关节外的泄漏，实验结果表明１６６Ｈｏ－ＥＤＴＭＰ－ＨＡ作为一种潜在的放射性滑膜切除治疗剂有进一步临床研究的价值。

Abstract

n order to treat the patients with inflammatory snovial diseases

HA particles was labelled with 166 Ho by EDTMPThe radiolabelling efficiency was more than 95%; size of particle was mainly at the range of 2—5μm; in vitro study showed that loss ratio of 166 Ho-EDTMP-HA particle incubating 72h in the nomal saline solution and 1% BSA solution was less than 2%In vivo biodistribution and extra articular leakage were in vestigated following injection of 166 Ho-EDTMP-HA into knees of normal rabbitsThe eperimental results found that etra articular leakage of 166 Ho-EDTMP-HA was 032% at 48h postinjection

most of 166 Ho that leaked from the knee joint was ecreted in urine

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