最新刊期
      卷 0 ， 期 0 ， 2020
      • Issue 5, (1995)
        摘要：I-labelled testosterone was prepared with a new klnd of bridge.The product was 125I-testosterone-3-（p-hydroxyphenylacetyl）hydrazone.To-3-HPAH was synthesized in three steps,identified by IR,NMR, MS and ultimate analysis,and then labelled with Na125Iby the chloramine-T method. The yield was higer than 85%.The radiochemical purity was higher than 95%when the product was purified by chloroform extraction and dropped slightly after a 50 days′storage at room temperature,  
          
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        发布时间：2021-04-09
      • Issue 5, (1995)
        摘要：Tracer experiment showed that 99mTc-PAHIDA was distributed predominantly in kidney.The distribution in other tissue was in the following descending order: heart,gastrointestinal tract, liver, spleen, muscle, adipose tissue, testes, and brain. The smaller the intravenous dose, the lower the proportion of the drug was combined to plasma protein and the more the drug was distributed in kidney.Excretion of 99mTc-PAHIDA via urine was rapid and was in its original form as shown by radiochromatogrphy.  
        关键词：enal agent;99mTc-PAHIDA;Metabolism   
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        发布时间：2021-04-09
      • Issue 5, (1995)
        摘要：Specific polyclonal antibodies against M1 and M2 subtypes of cholinergic receptors were prepared in this laboratory.The M-cholinoceptor molecules in brain homogenate were solubilized with 1% digitonin and labelled with 3H-QNB prior to immumuprecipitation. One of the specific antibodies was then added to form antigen-antibody complex with the respective subtype and the complex was precipitated by the aid of a second antibody. Thus the receptor-ligand binding parameters of a single subtype were obtained from the radioactivities of the precipitates.Typical single- site saturation curves were obtained for both M1 and M2 subtypes.No influence of the antibodies on receptor-ligand binding was detected.Results of studies on the solubilization of menbrane receptors, the time course of antibody-antigen reaction,the optimal dilution factor and the reaction temperature are also presented in the paper.  
        关键词：Cholinergic receptors;Receptor subtype;Radioligand binding assay;Immunoprecipitation   
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        发布时间：2021-04-09
      • Issue 5, (1995)
        摘要：Radionuclide phase analysis（RPA） was carried out in 15 normals and 17 Wolff-Parkinson-White（W-P-W）syndrome before and after RFCA（radiofrequency ablation）.VW（ventricular phase angle width） for the patients before RFCA were significantly wider than that for the normal group and the patients after RFCA（P<0.01）, but there was no significant difference between normal group and the patients after RFCA（P>0.05）. Also, no significant difference in the left ventricular cardiac function was observed among the normal subjects,before and after RFCA（P>0.05）.The localization of bytract was correlated well with the electrophysiological study.Usually the pre--excite sites still existed within one week after RFCA, but disappeared after one week.In conclusion,RPA is a noninvasive,effective method for diagnosing W-P-W syndrome,estimating the effect of RFCA and detecting cardicac function.  
        关键词：Radionuclide phase analyses;Radiofrequency ablation;Wolff-Parkinson-White syndrome;Paroxysmal supraventricular tachycardia   
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        发布时间：2021-04-09
      • Issue 5, (1995)
        摘要：Radionuclide bone imaging was performed to evaluate bone metabolic activity after transplantation with coral combined autologous red marrow and the single coral group. The result was also compared with histological and X-ray examination.This finding revealed that 99mTc-MDP concentration in the area of the transplanted bone changed dynamically and reached its maximum in 12 weeks following operation and showed various bone metabolic activities with different grafting materials. Clinical application showed that three phase bone imaging could evaluate the blood supply and activity of growthing bone of the graft two months earlier than X-ray examination. It was considered that non-accumulation of 99mTc-MDP in grafted area was a realiable indication of failure in transplantation one month after operation.  
        关键词：Radionuclide bone imaging;Bone metabolic activity;Bone transplantation;99mTc-MDP   
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        发布时间：2021-04-09
      • Issue 5, (1995)
        摘要：重视神经核医学应用基础研究林祥通（上海医科大学华山医院上海２０００４０）本刊这期发表了三篇涉及神经核医学应用基础研究的论文。自“医学中的核技术应用”专刊创办三年多来，本刊重视发表了有关神经核医学应用基础的论著，这是十分可喜的。基础研究是新技术的先导和...  
          
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        发布时间：2021-04-09
      • Issue 5, (1995)
        摘要：The synthesis,labelling and animal experiment of p-iodophentermine as a brain perfusion imaging agent are reported.The result showed that the incorporation of methyl groups increases the lipophilicity,and facilitates the passage across the blood-brain barrier.Therefore the compound appears to be a potential brain perfusion imaging agent.  
          
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        发布时间：2021-04-09
      • Issue 5, (1995)
        摘要：To relieve bony pain due to disseminated bone metastases,72 patients were treated with 90Y-EDTMP with dosage of 7.4-9.25 mBq/kg in 122 times.53 patients were followed,among them 13 had significant pain relief,28 effective,the overall effective ratio was 77.4%（41/53）.In 17 patients transcient decreasing of the peripheral blood cell occured, and 7 patients had reactive pain aggravation in short duration. No irreversible bone marrow depression and liver function injury was found. It was considered 90Y-EDTMP is an easy,less side effect and effective method for the relief of bone metastetic pain.  
        关键词：Bone metastases;Treatment;90Y-EDTMP   
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        发布时间：2021-04-09
      • Issue 5, (1995)
        摘要：The ligand exchange reaction between EC and 99mTc-GH and its influence factors such as concentrations of EC and pH were described in this paper.The concentration of EC has no influence on the exchange reaction rate constant,while pH is the most important influence factor.The rate constants of ligand exchange reaction at different pH values were determined.The results showed that in order to make the labelling yield of 99mTc-EC higher than 90%,pH of the reaction must be higher than 8.  
          
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        发布时间：2021-04-09
      • Issue 5, (1995)
        摘要：The PTH-IRAM in 30 cases and the serum calcium in 23 cases with chronic renal failure are determined to be 13.04±10.32pmol/L and 2.08±0.22mmol/L respectively.Among the 30 cases, there are 22 cases（73.33%） to present the elevation of PTH-IRAM, and among the 23 cases there are 17 cases（73.91%） to show the decreasing tendency of the serum calcium. In 17 cases, there is a remarkable negative correlation（|r|=0.486）between PTH-IRAM and the sertun calcium, while blood urea nitrogen and creatine show remarkable positive correlation （|r|>0.482） with PTH. All of these show a very close relationship between PTH and the function of the kidney. In conclusion, to check PTH-IRAM and the serum calcium at the same time is of great value to judge the function of the kidney and to evaluate clinical therapeutic effect.  
        关键词：Chronic renal failure;PTH-IRAM;Serum calcium;Blood uera nitrogen;Creatine;Radio-immunity   
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        发布时间：2021-04-09
      • Zhu Xiaobo
        Issue 5, (1995)
        摘要：Clinical examination revealed that either radiation sterilized skin or Ag-skin of pig are effective biologic dressing.When used as temporary skin coverage for fresh burn wound,for wound after escharectomy, and for wounds among skin grafts,they are effective in preventing infection and loss of body fluid.They can also be used for covering the infected granulation wound to control bacterial growth and further contamination.  
        关键词：Skin of pig;Burn wound   
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        发布时间：2021-04-09
      • Huang Tiansen
        Issue 5, (1995)
        摘要：The relative contents of CL-19-131I（131I-19-iodocholest-5-en-3β-ol）and NCL-6-131I（131I-6β-iodomethyl-19-norcholest-5（10）-en-3β-ol） in seven batches of 131I-iodocholesterol prepared by Shanghai First Chemical Reagent Factory were determined by means of thin layer chromatography. It was found that when the ratio of CL-19-131I to NCL-6-131I was calculated, there was a negative correlation between this ratio and the adrenal gland uptake of 131I.A negative correlation was also found between this ratio and the heat stability of 131I-iodocholesterol.Therefored NCL- 6- 131I appears to be the better imaging agent for adrenal medulla.  
        关键词：Radioactive pharmaceutical;Radioiodinated steroids;Adrenal   
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        发布时间：2021-04-09
      • Issue 5, (1995)
        摘要：uman gastric inhibitory polypeptide（GIP）was labelled with the conjunction method. The results showed that the conjunction method succeeds in protecting the immunoactivity of human GIP. The 125I-GIP was able to combine with its GIP antibody specifically. The binding rate was 50% at an antisertum dilution of 1:3×104.  
        关键词：Human gastric inhibitory polypeptide;Conjunction method;Acylating agent   
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        发布时间：2021-04-09
      • Issue 5, (1995)
        摘要：The concentrations of thyroid hormone were determined and analysed in 200 cases of hepatic diseases.It was demonstrated that there was some changes in their thyroid hormone concendation.  
        关键词：Non-thyroid illness;Radioimmunoassay;Thyroid hormone   
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        发布时间：2021-04-09
      • Issue 5, (1995)
        摘要：The rat model with regional cerebrovascular ischemia, mimic the course of human cerebral thrombosis and simulating the 99mTc-HM-PAO distribution of ischemic apoplexy,were used in this study. After the occlusion of middle cerebral artery（MCAo）,the activity ratio of lesion to normal side was 0.77±0.24（n= 11）,which showed significant difference with control group（p<0.05）,and also coincided with the pathological findings and neurological changes.All of this verified that the distribution of 99mTc-HM-PAO was well correlated with the brain blood perfusion.  
          
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        发布时间：2021-04-09
      • Issue 5, (1995)
        摘要：This paper presented the levels of plasma renin activity（PRA） and angiotensin Ⅱ（ATⅡ）in 70 cases of normals and 128 cases of essential hypertension（EH）. The results showed that normal plasma PRA（70 cases） and ATⅡ （40 cases） were 0.432±0.236 μg/（L·h）,and 31.7±7.4 ng/L respectively.In 128 cases of EH plasma PRA increased, normal and decreased in 18.0%, 71.8% and 10.2% of cases; while ATⅡ in 14%, 64.2% and 14.9% respectively. It was concluded that grouping of EH by plasma.PRA and AT Ⅱlevel may provide a good indices for treatment.  
        关键词：Plsma renin activity（PRA）;Angiotension Ⅱ（AT Ⅱ）;Typing;Essential hypertension   
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        发布时间：2021-04-09
      • Issue 5, (1995)
        摘要：The level of CYFRA21-1 and CEA were determined in patients with lung cancer by RIA.The all over detection rate of CYFRA 21-1 was 52.9%,among them highest in squamous carcinoma 59.3%,and none of the cases in benign lung tumor was positive.As for CEA determination,the over all detection rate only reached 28.6%,among them,highest in adenocarcinoma 51.6%,only 7.4% in squamous carcinoma.Combined determination of CYFRA21-1 and CEA was recommended as the detection rate can raised up to 64.5%.  
        关键词：Lung cancer;Adenocarcinoma;Squamous carcinoma;CYFRA21-1;CEA;RIA   
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        发布时间：2021-04-09
      • Issue 5, (1995)
        摘要：This study reported that anti-ferritin McAb A-hF-C and its F（ab′）2 were lablelled with 99mTc by Pretinning′s method. Labelling rate was over 90%.McAb′s immunoactivity well preserved. Intact McAb was mainly distributed at kidney,liver and blood, while F（ab′）2 to kidney, liver and spleen. McAb well accumulated in HepG2 tumor, LI was over 2.5.The A-hF-C was labelled with 125I by Iodogen′s method.Intact McAb had the highest radioactivity in blood,F（ab′）2 in kidney.The labelled McAb localized at HepG2 tumor,LI reached to 3.5.  
        关键词：Monoclonal antibody;99mTc;125I;Labelling;Tumor;Pharmacodynamics   
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        发布时间：2021-04-09
      • Issue 5, (1995)
        摘要：Gd-DTPA was synthesized by 153GdCl3 and DTPA.The mice killed and biodistribution of the organs measured at 5,15,30,60,120 and 180 min post-injection. Blood 153Gd-DTPA clearence curve conformed a two-compartment open model,t1/2（1）= 1.smin,t1/2（2）= 29.gmin. Determination of urine 153Gd-DTPA concentration find: t1/2=16min.Within three hours,90 percent of the drug was concentrated in urine, thereby mainly excreated through kidney.  
        关键词：Contrast-enhancing agent;Gadolinium-diethylenetriamine pentaacetic acid;153Gd;Pharmacokinetic   
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        发布时间：2021-04-09
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