Labelling of ￣（99m）Tc,￣（125）I anti-ferritin McAb A-hf-C and its biodistribution study in tumor bearing nude mice

您当前的位置：

首页 >

文章列表页 >

Labelling of ￣（99m）Tc,￣（125）I anti-ferritin McAb A-hf-C and its biodistribution study in tumor bearing nude mice

更新时间：2021-04-09

- Labelling of ￣（99m）Tc,￣（125）I anti-ferritin McAb A-hf-C and its biodistribution study in tumor bearing nude mice
- NUCLEAR TECHNIQUES Issue 5, (1995)
- 作者机构：
  
  1. 上海市第六人民医院
  2. 中国科学院上海生物化学研究所
  3. 上海市第六人民医院中国科学院上海生物化学研究所
- 作者简介：
- 基金信息：
- DOI：
  CLC： R969.1
- Published：01 May 1995
- 稿件说明：
移动端阅览
[1]余永利,马寄晓,金常青,张德胜,张祖传.抗人铁蛋白单抗A—hF—C的~（99m）Tc、~（125）I标记和在荷瘤裸鼠体内分布研究[J].核技术,1995(05):309-312.

Labelling of ￣（99m）Tc,￣（125）I anti-ferritin McAb A-hf-C and its biodistribution study in tumor bearing nude mice[J]. Nuclear techniques, 1995, (5).
[1]余永利,马寄晓,金常青,张德胜,张祖传.抗人铁蛋白单抗A—hF—C的~（99m）Tc、~（125）I标记和在荷瘤裸鼠体内分布研究[J].核技术,1995(05):309-312. DOI：

Labelling of ￣（99m）Tc,￣（125）I anti-ferritin McAb A-hf-C and its biodistribution study in tumor bearing nude mice[J]. Nuclear techniques, 1995, (5). DOI：

摘要

用Ｐｒｅｔｉｎｎｉｎｇ法进行９９ｍＴｃ标记抗人铁蛋白单抗Ａ－ｈＦ－Ｃ及其Ｆ（ａｈ’）。，标记率达９０％以上，抗体活性保持良好。标记抗体在荷人肝癌裸鼠活体内分布表明，完整抗体的放射活性分布主要在肾、肝脏和血液；片段则主要在肾、肝和脾脏。抗体较好地依聚于ＨｅＰＧ。肿瘤，定位指数ＬＩ大于ｚ．５。用改良Ｉｏｄｏｇｅｎ法进行”‘Ｉ标记，完整抗体以血液中放射活性最高，片段则以肾脏最高。标记抗体定位于ＨｅｐＧ。肿瘤；ＬＩ达３．５。

Abstract

This study reported that anti-ferritin McAb A-hF-C and its F（ab′）2 were lablelled with 99mTc by Pretinning′s method. Labelling rate was over 90%.McAb′s immunoactivity well preserved. Intact McAb was mainly distributed at kidney

liver and blood

while F（ab′）2 to kidney

liver and spleen. McAb well accumulated in HepG2 tumor

LI was over 2.5.The A-hF-C was labelled with 125I by Iodogen′s method.Intact McAb had the highest radioactivity in blood

F（ab′）2 in kidney.The labelled McAb localized at HepG2 tumor

LI reached to 3.5.

关键词

Keywords

references

0

Views

54

下载量

0

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Related Articles

Investigation of McAb labelling with 99m Tc by avidin-biotin system and its biodistribution in mice

Radiolabeling of anti-carbonic anhydrase IX monoclonal antibody by ⁹⁹Tc^m and its imaging in the mouse bearing tumors

Labeling monoclonal antibody 10D9 with ¹²⁵I using the Iodogen method

Precursor synthesis of molecular probe of estrogen receptor β and the ^99mTc radiolabeling

Preparation of ¹³¹I-23-hydroxybetulinic acid and in vivo evaluations in liver cancer HepA tumor-bearing mice

Related Author

Yu Yongli 1 Cao Rongzhen 2 Zhang Desheng 3 Dong Mo 2 Zhang Zuchuan 3 Ma Jixiao 1 1

曹蓉珍

张德胜

董墨

张祖传

马寄晓

LI Jianbo1

2 SHEN Hua1 NIU Tingting3 ZHANG Xiaohui1

Related Institution

上海市第六人民医院中国科学院上海原子核研究所中国科学院上海生物化学研究所

中国科学院上海生物化学研究所

中国科学院上海原子核研究所

Shanghai Sixth People’s Hospital, Shanghai 200233) 2

Shanghai Institute of Applied Physics,Chinese Academy of Science,Shanghai 201800,China) 2

AI问答

Address：2019 Jialuo Road, Jiading, Shanghai, China Postal code：201800
Tel：021-39194977 Email：LHB@sinap.ac.cn
Technical support is provided by Beijing Founder electronics co., LTD 沪ICP备05005479号-1 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.
Total Visits：880780 Visits Today：307

⁰