Tracer experiment showed that 99mTc-PAHIDA was distributed predominantly in kidney.The distribution in other tissue was in the following descending order: heart
gastrointestinal tract
liver
spleen
muscle
adipose tissue
testes
and brain. The smaller the intravenous dose
the lower the proportion of the drug was combined to plasma protein and the more the drug was distributed in kidney.Excretion of 99mTc-PAHIDA via urine was rapid and was in its original form as shown by radiochromatogrphy.
Preparation, in vivo metabolism and distribution of TagS750-Cas9 nuclease
Study of urinary metabolites of perlolyrine in rats by stable isotope tracing method
A study on the metabolism of Cr(Ⅲ) in rats by radioactive tracer technique
The distribution of 125I-α2-macroglobulin in mice
Label of 99mTc-hexakis (t-butylisonitrile) and its metabolism and distribution in rats
Related Author
RAN Tiecheng
KONG Huating
ZHANG Jichao
ZHANG Yu
ZHU Ying
YAN Qinglong
TANG Ganghua
姜国辉
Related Institution
Division of Physical Biology, CAS Key Laboratory of Interfacial Physics and Technology, Shanghai Synchrotron Radiation Facility, Shanghai Institute of Applied Physics, Chinese Academy of Sciences
Zhangjiang Laboratory, Shanghai Advanced Research Institute, Chinese Academy of Sciences