￣（99m）Tc-HM-PAO cerebral perfusion study on rat middle cerebral artery occlusion models

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￣（99m）Tc-HM-PAO cerebral perfusion study on rat middle cerebral artery occlusion models

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- ￣（99m）Tc-HM-PAO cerebral perfusion study on rat middle cerebral artery occlusion models
- NUCLEAR TECHNIQUES Issue 5, (1995)
- 作者机构：
  
  上海医科大学华山医院
- 作者简介：
- 基金信息：
- DOI：
  CLC： R331
- Published：01 May 1995
- 稿件说明：
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[1]陈文新,刘永昌,林祥通,薛方平,梁勇.大鼠大脑中动脉区脑梗塞模型的建立及~（99m）Tc—HM—PAO血流灌注研究[J].核技术,1995(05):259-262.

￣（99m）Tc-HM-PAO cerebral perfusion study on rat middle cerebral artery occlusion models[J]. Nuclear techniques, 1995, (5).
[1]陈文新,刘永昌,林祥通,薛方平,梁勇.大鼠大脑中动脉区脑梗塞模型的建立及~（99m）Tc—HM—PAO血流灌注研究[J].核技术,1995(05):259-262. DOI：

￣（99m）Tc-HM-PAO cerebral perfusion study on rat middle cerebral artery occlusion models[J]. Nuclear techniques, 1995, (5). DOI：

摘要

应用显微外科技术，在建立稳定可靠、重复性好、与人的脑栓塞病程相近的大鼠局灶性脑缺血模型的基础上，模拟出缺血性中风患者的脑内９９ｍＴｃ－ＨＭ－ＰＡＯ的分布状况。１１只大鼠大脑中动脉阻塞（ＭＣＡｏ）后病灶侧与健侧的放射性计数比值为０．７７±０．２４，与对照组的比值有显著性差异（Ｐ＜０．０５），与病理所见及神经症状改变的符合性好．印证了９９ｍＴｃ－ＨＭ－ＰＡＯ能很好地反映脑血流灌注状况，用于脑疾病的临床诊断有确切的意义。

Abstract

The rat model with regional cerebrovascular ischemia

mimic the course of human cerebral thrombosis and simulating the 99mTc-HM-PAO distribution of ischemic apoplexy

were used in this study. After the occlusion of middle cerebral artery（MCAo）

the activity ratio of lesion to normal side was 0.77±0.24（n= 11）

which showed significant difference with control group（p<0.05）

and also coincided with the pathological findings and neurological changes.All of this verified that the distribution of 99mTc-HM-PAO was well correlated with the brain blood perfusion.

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