Synthesis and biodistribution of ￣（153）Gd-DTPA in mice

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Synthesis and biodistribution of ￣（153）Gd-DTPA in mice

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- Synthesis and biodistribution of ￣（153）Gd-DTPA in mice
- NUCLEAR TECHNIQUES Issue 5, (1995)
- 作者机构：
  
  1. 上海医科大学附属华山医院
  2. 上海淮海药厂
  3. 上海医科大学附属华山医院上海淮海药厂
- 作者简介：
- 基金信息：
- DOI：
  CLC： R969.1
- Published：01 May 1995
- 稿件说明：
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[1]李明,林祥通,程伟,管一晖,施孝金,郑传钧.~（153）Gd—DTPA的合成及其在小鼠体内分布的实验研究[J].核技术,1995(05):278-281.

Synthesis and biodistribution of ￣（153）Gd-DTPA in mice[J]. Nuclear techniques, 1995, (5).
[1]李明,林祥通,程伟,管一晖,施孝金,郑传钧.~（153）Gd—DTPA的合成及其在小鼠体内分布的实验研究[J].核技术,1995(05):278-281. DOI：

Synthesis and biodistribution of ￣（153）Gd-DTPA in mice[J]. Nuclear techniques, 1995, (5). DOI：

摘要

利用放射性元素１５３Ｇｄ合成１５３Ｇｄ－ＤＴＰＡ，经小鼠尾静脉注射后，取５、１５、３０、６０、１２０、１８０ｍｉｎ六个时相处死小鼠，解剖，测量各脏器放射性计数，计算得到不同时相１５３Ｇｄ－ＤＴＰＡ在各脏器的分布情况。血药清除符合二室模型，ｔ１／２（１）＝１．５ｍｉｎ、ｔ１／２（２）＝２９．９ｍｉｎ，尿液中药物排泄量ｔ１／２＝１６ｍｉｎ，３ｈ时药物９０％量在膀胱中。该药物主要通过肾脏代谢，其余脏器摄取甚少。通过１５３Ｇｄ－ＤＴＰＡ动物实验研究得到了Ｇｄ－ＤＴＰＡ的药代动力学数据。

Abstract

Gd-DTPA was synthesized by 153GdCl3 and DTPA.The mice killed and biodistribution of the organs measured at 5

120 and 180 min post-injection. Blood 153Gd-DTPA clearence curve conformed a two-compartment open model

t1/2（1）= 1.smin

t1/2（2）= 29.gmin. Determination of urine 153Gd-DTPA concentration find: t1/2=16min.Within three hours

90 percent of the drug was concentrated in urine

thereby mainly excreated through kidney.

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