Radionuclide bone imaging was performed to evaluate bone metabolic activity after transplantation with coral combined autologous red marrow and the single coral group. The result was also compared with histological and X-ray examination.This finding revealed that 99mTc-MDP concentration in the area of the transplanted bone changed dynamically and reached its maximum in 12 weeks following operation and showed various bone metabolic activities with different grafting materials. Clinical application showed that three phase bone imaging could evaluate the blood supply and activity of growthing bone of the graft two months earlier than X-ray examination. It was considered that non-accumulation of 99mTc-MDP in grafted area was a realiable indication of failure in transplantation one month after operation.