最新刊期
      卷 0 ， 期 0 ， 2020
      • Yang Yifeng Qian Zhonghao Jiang Changying Hong Yuling Zou Lihua Du Weiyun Chen Haozhu
        Issue 5, (1993)
        摘要：A prognostic study of dipyridamole- thallium myocardiac imaging was conducted with use of logistic regression. Over a 5 years follow- up period, cardiac events occurred in 13 patients within the 41 patients tested, death in 5 and myocardiac infarction in .8. The results of this study indicates that dipyridamole- thallium imaging has significant prognostic utility and that an abnormal scan increased the relative risk for the development of subsequent myocardial infarction or cardiac death （O.R. = 18.54）. The presence of transient multiple thallium defects further increased the risk of a cardiac event. In conclusin, intravenous dipyridamole-thallium imaging is a potentially useful diagnostic test to determine the presence and severity of coronary diseases, and this noninvasive method is also beneficial for prognosis.  
          
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        发布时间：2021-04-09
      • Wu Naiyun Gui Zhining Lu Hanping Zhang Huaide
        Issue 5, (1993)
        摘要：This paper reports the contents of lymphocyte glucocorticoid receptors （GCR） in 48 patients with nephrotic syndrome, using radioligand binding assay of receptors. The contents of GCR in patients with nephrotic syndrome was 18936±10097 binding sites/cell in adult and 9274 ± 3847 binding sites/cell in children. There was significant difference between them （P<0.05）. The contents of GCR in children and adult with nephrotic syndrome were significantly higher than that in normal ones （p<0.05）. There were no significant difference between the contents of GCR in different sex and age groups （p> 0.05）. The contents of GCR in patients with nephrotic syndrome was significantly increased. This result suggested that contents of GCR in lymphocytes are correlated with nephrotic syndrome, and the treatment of nephrotic syndrome may be effective by hormaonal therapy.  
          
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        发布时间：2021-04-09
      • Wu Chunying Kuang Qinfang Fang Ping Guo Yuzhi Feng Yingying Luo Shineng Xie Minhao Xi Yuefen
        Issue 5, (1993)
        摘要：99mTc-EC （L,L ethylenedicystein） is a new renal functional agent. The preparation and its radiochemistry study, animal study were reported in the paper. 99mTc-EC can he easily prepared by two methods, one is direct labelling without boiling, the other is ligand exchange labelling. Labelling yield and radiochemical purity of 99mTc-EC were both better than 95% as confirmed by TLC and HPLC. Study on the influence of labelling conditions on radiochemical purity showed that pH is the most important influence factor: it must be over 10 in direct labelling, but may be as low as 8 for ligand exchange labelling. Renograms in rabbits showed that the T1/2 and Tmax of 99mTc EC are similar to that of131I-OIH. In mice, the biodistribution in kidneys was 14.55 and 3.11 （% I.D/organ） at 1 and 10min postinjection. The simple labelling procedure for 99mTc-EC and its good biological characteristics make it a more practical tracer agent than 99mI-OIH and 99mTc-MAG3 for renal functional study.  
          
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        发布时间：2021-04-09
      • Wang Qiang Zhu Tong Zhu Gengen Shen Chengwu
        Issue 5, (1993)
        摘要：Characteristics of [3H]- Sulpiride binding in rat striatal membranes by ligand binding assay were analyzed. The results showed that the binding is specific, saturable, reversible and selective. Scatchard analysis of the data revealed a single binding component with a dissociation constant （Kd） of 5.17±1.13nmol/l （X±SD, n = 5） and a maximum binding capacity （Bmax） of 917.0±133.2fmol/mg protein （X±SD, n = 5）. Based on the ligand binding assay, [3H]- Sulpiride radioligand assay has been developed. The linear range of the assay was 1-100nmol/l. The sensitivity was 49.25pg/ml. The coefficients of intra- and interassay variation were 3.35% （n = 10） and 10.6% （re = 4）, respectively.  
          
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        发布时间：2021-04-09
      • Qiu Guilin Shi Jianguo Yuan Shidong
        Issue 5, (1993)
        摘要：The application of radionuclide procedures to 279 patients of thyroid disorder were evaluated. TSH IRMA test, total T3 and T4, free T3 and T4, TMAb and TGAb thyroid uptake percentage and also the thyroid imaging were used. All of the results demonstrated and concluded that the TSH IRMA, free T3 and free T4 tests were the most sensitive one and should be the first choice method used for the evaluation of thyroid function.  
          
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        发布时间：2021-04-09
      • Yuan Jimin Zhu Cuiying Cui Wenru
        Issue 5, (1993)
        摘要：The serum TSH level of 303 healthy persons ranged from 0.3-5.6 mU/1 and 205 cases of hyperthyroidism, 56 cases of early stage hyperthyroidism, 67 cases of subclinical hyperthyroidism ranged < 0.02-0.69 mU/1 were reported. TSH levels in 95% patients of subclinical hyperthyroidism was <0.3 mU/1 and about 2/3 patients was nondetectable（<0.02 mU/1）. For the thyrotoxicosis after therapy, TSH is the best parameter for the monitoring of its recurence. And better than FT3 as far as the sensitivity for the diagnosis and prognostic monitoring of thyrotoxicosis is concerned. Comparison of TSH（64 cases） and TSH stimulating test was highly correlated, therefore the application of latter test can be greatly reduced. And also the establishment and application of TSH（IRMA） gives a strategic change of the diagnostic procedure of thyroid function test.  
          
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        发布时间：2021-04-09
      • Lin Baoyuan Xiong Jiwang Ren Yuan
        Issue 5, (1993)
        摘要：Serum TT3, TT4) TSH, CT, PTH, E2 and testosterone RIA were determind in 37 pilots with low bone density （investigated group）, 48 pilots with normal bone density and in 100 ground-crews as the control group. Bone density in investigated group was significantly less than that in the control group （p<0.01）. Serum TT3, TT4, CT, E2 （female） and T （male） in investigated group were also significantly less than those in the control group （p<0.05 or <0.01）. Finally the correlation of bone density with some hormone levels in pilots was discussed.  
          
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        发布时间：2021-04-09
      • Zhao Zhoushe Zhou Qian
        Issue 5, (1993)
        摘要：According to the minimum mean square error between the object and the image, the selection of an optimal parameter of the Metz filter is reported. The result indicate that （1） there is a significant correlation between the X parameter and the first projection counts and total counts; and （2） the Metz filter possesses the optimal filtering function and X parameter can be practically and accurately estimated from the first projection using a regression formula.  
          
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        发布时间：2021-04-09
      • Lin Mingdong Hu benrong Zeng Xilan
        Issue 5, (1993)
        摘要：Application of the determination of adenylate cyclase activity to the studies of Chai Hu has been reported. The results show that this method can be used for the determination of activation, inhibition, and activation/inhibition dual action of drugs on adenylate cyclase; and, with the pre-incubation with receptor blockers it can be used to investigate the mechanism by which the drugs affected the activity of adenylate cyclase. The result of the enzymatic activity determination is consistent with that of the biological effect. By using this method, some interesting results discovered were in the studies of effective fractions of Chai Hu.  
          
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        发布时间：2021-04-09
      • Mo Qizhong Gong Bin Fang Jun Chen Kunhua Li Weixiong Wang JumeiKuang Xingwei Chen Rong
        Issue 5, (1993)
        摘要：3H- QNB and 3H- GABA were used as radioactive ligand for M- and GABA receptors respectively. M- and GABA receptors were assayed by radioligand binding assay （RBA） in cerebral cortex, hippocampus and cerebellum of analogue dementia rats. It was found that Rt of M receptor was decreased in cerebral cortex and hippocampus and Rt of GABA receptor was decreased in cerebellum of analogue dementia rats. The dissociation constant （KD） of M- receptor was decreased significantly in cerebral cortex and KD value of GABA receptor was decreased in cerebellum of analogue dementia rats. The decreased Rt of M- and GABA receptor in brain tissue of analogue dementia rats was raised by Heart- and Kidney-Benefiting Chinese Herbs as well as hydergin.  
          
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        发布时间：2021-04-09
      • Zhou Jun Shen Zhongli Gong Bin Le Xiuzhen
        Issue 5, (1993)
        摘要：50 patients suffering from uterine myofibroma were treated with "861 Xiao Liu Pian". Six months after the treatment, the ratio of disappearance of the myofibroma was 26% and the reduction ratio was 46%. The levels of FSH, LH, E2, P and T in plasma of 22 patients were determined before and after the treatment. It was found that the amount of P before treatment was obviously less than that of the control women （n=15, p<0.05） and the amount of P during secretion period after the treatment rose remarkably （p< 0.05）. In addition, the densities of EnR in myofibroma tissues of 30 patients were significantly reduced in the treated group than in control group（p<0.05）. The present work suggested that the mechanism of the action of "861 Xiao Liu Pian" might probably be the regulation of endocrine function and the suppression of ER level in myofibroma tissues.  
          
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        发布时间：2021-04-09
      • Wang Zhenli Liu Guimin
        Issue 5, (1993)
        摘要：The sensitizing effects of POPOP, PBD and PPO were compared in 3H-TdR incorporation experiment, 3H-TdR low and high concentration twice labelling experiment and a cell migration tracer experiment. The results indicate that 7.5% PPO in xylene with an exposure time of 48 h is most satisfactory. The efficiency was increased for 15-20 times.  
          
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        发布时间：2021-04-09
      • Zhu Shoupeng Cao Genfa Sun Baofu
        Issue 5, (1993)
        摘要：The purpose of this work is to study the correlation between the accumulation of 147Pm in bone and its possible mutagenic effect in organism. When given i.v. to male rats, 147Pm was selectively localized in skeleton. The retention data in bone were well described by an exponential expression. It caused marked chromosome aberrations in bone marrow cells. There was positive relationship between chromosome aberration rates and the amount of 147Pm administered. Most of the chromosome aberrations induced by 147Pm were of chromatid type. Chromatid deletions were predominant accompanied with a few chromosome aberrations.  
          
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        发布时间：2021-04-09
      • Zhao Jie Ma Qingjie Xiao Yanling
        Issue 5, (1993)
        摘要：The in vitro stability and immunoreactivity of 125I-anti-Tg-McAb were investigated in various storage conditions and also its stability in normal human plasma. The results showed that 125I-anti-Tg-McAb demonstrated marked differences in stability and immunoreactivity in various storage conditions. The best immunoreactivity and stability of 125I-anti-Tg-McAb was acquired in low and median specific radioactivity, with pH 6.3-7.4 and preserved at -20℃.  
          
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        发布时间：2021-04-09
      • Xie Minhao Luo Shineng Fang Ping Kuang Qinfang Feng Yingying Xi Yuefen
        Issue 5, (1993)
        摘要：99mTc- MIBI is a valuable myocardial perfusion imaging agent. In order to explore the optimal condition for the preparation of Tc- MIBI, the thermodynamics of preparation reaction was studied using MIBI freeze- dried kit. The result shows that the preparation of 99mTc- MIBI exhibits a endothermic reaction. The reaction heat （△H） was equal to 339.2 kJ/mol. In order to make the labelling yield of Tc- MIBI higher than 90%, the reaction temperature should be over 77℃.  
          
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        发布时间：2021-04-09
      • Jin Zhikui Zeng Qin Liu Junmao Wang Aihua Wang Jing Shao Hesheng Zhang Qiang
        Issue 5, (1993)
        摘要：This study attempted to assess the clinical feasibility of pancreas scintgraphy using 131I- HIPDM. The pancreas of 10 normal volunteers, 6 cases of pancreas cancer and 4 cases of chronic pancreatitis were studied. In 7 cases, excellent SPECT pancreas images was obtained due to exclusion of the overlapping with the radioactivity around the liver and spleen area.  
          
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        发布时间：2021-04-09
      • Lu Jiaben Huang Yinmei Zhu Bingchai
        Issue 5, (1993)
        摘要：The radioprotective action of mixed tremella preparation（Yinshen Yin） on whole body gamma irradiated dogs has been studied. 25 male dogs were divided into five groups: tremella, mercaminum,Yinshen Yin at high dose, Yinshen Yin at low dose and control. All the dogs were given above drugs in 10 successive days before acute exposure of 1 Gy radiation. The results showed that the prophylaxtic use of Yinshen Yin had good anti- irradiation effect, and the radioprotective effect was similar to the mercaminum, but significantly higher than tremella. Thereby it was considered as a good radioprotective agent. The dose reduction factor in different groups were: Yinshen Yin high dose 2.01, Yinshen Yin low dose group 1.72, mercaminum group 1.55 and tremella group 1.11.  
          
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        发布时间：2021-04-09
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