The effect of Heart- and Kidney- Benefiting Chinese Herbal Medicines on the function of cholinergic M- and Gamma ammo- butyric acid (GABA) receptor in brain tissues of analogue dementia rats
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The effect of Heart- and Kidney- Benefiting Chinese Herbal Medicines on the function of cholinergic M- and Gamma ammo- butyric acid (GABA) receptor in brain tissues of analogue dementia rats
Mo Qizhong Gong Bin Fang Jun Chen Kunhua Li Weixiong Wang JumeiKuang Xingwei Chen Rong. The effect of Heart- and Kidney- Benefiting Chinese Herbal Medicines on the function of cholinergic M- and Gamma ammo- butyric acid (GABA) receptor in brain tissues of analogue dementia rats[J]. Nuclear techniques, 1993, (5): 295-298.
Mo Qizhong Gong Bin Fang Jun Chen Kunhua Li Weixiong Wang JumeiKuang Xingwei Chen Rong. The effect of Heart- and Kidney- Benefiting Chinese Herbal Medicines on the function of cholinergic M- and Gamma ammo- butyric acid (GABA) receptor in brain tissues of analogue dementia rats[J]. Nuclear techniques, 1993, (5): 295-298.DOI:
The effect of Heart- and Kidney- Benefiting Chinese Herbal Medicines on the function of cholinergic M- and Gamma ammo- butyric acid (GABA) receptor in brain tissues of analogue dementia rats
3H- QNB and 3H- GABA were used as radioactive ligand for M- and GABA receptors respectively. M- and GABA receptors were assayed by radioligand binding assay (RBA) in cerebral cortex
hippocampus and cerebellum of analogue dementia rats. It was found that Rt of M receptor was decreased in cerebral cortex and hippocampus and Rt of GABA receptor was decreased in cerebellum of analogue dementia rats. The dissociation constant (KD) of M- receptor was decreased significantly in cerebral cortex and KD value of GABA receptor was decreased in cerebellum of analogue dementia rats. The decreased Rt of M- and GABA receptor in brain tissue of analogue dementia rats was raised by Heart- and Kidney-Benefiting Chinese Herbs as well as hydergin.
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Gong Bin Mo Qizhong Fang Jun Chen Kunhua Li Weixiong Wang Jumei Kuang Xingwei Chen Rong