The study of a new renal functional agent of <sup>99m</sup>Tc-EC

Wu Chunying Kuang Qinfang Fang Ping Guo Yuzhi Feng Yingying Luo Shineng Xie Minhao Xi Yuefen

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The study of a new renal functional agent of ^99mTc-EC

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- The study of a new renal functional agent of ^99mTc-EC
- NUCLEAR TECHNIQUES Issue 5, (1993)
- 作者机构：
  
  1. 江苏省原子医学研究所
  2. 江苏省原子医学研究所,无锡,214063
- 作者简介：
- 基金信息：
- DOI：
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- Published：01 May 1993
- 稿件说明：
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[1]吴春英,匡琴芳,方平,国毓智,冯瑛瑛,罗世能,谢敏浩,奚月芬.新的肾功能显像剂~(99m)Tc—EC的研究[J].核技术,1993(05):265-270.

Wu Chunying Kuang Qinfang Fang Ping Guo Yuzhi Feng Yingying Luo Shineng Xie Minhao Xi Yuefen. The study of a new renal functional agent of ^99mTc-EC[J]. Nuclear techniques, 1993, (5): 265-270.
[1]吴春英,匡琴芳,方平,国毓智,冯瑛瑛,罗世能,谢敏浩,奚月芬.新的肾功能显像剂~(99m)Tc—EC的研究[J].核技术,1993(05):265-270. DOI：

Wu Chunying Kuang Qinfang Fang Ping Guo Yuzhi Feng Yingying Luo Shineng Xie Minhao Xi Yuefen. The study of a new renal functional agent of ^99mTc-EC[J]. Nuclear techniques, 1993, (5): 265-270. DOI：

摘要

报道了采用直接标记及配体(

99m

Tc-葡庚糖酸钠)交换法制备

99m

Tc-EC的两种方法;TLC和HPLC检测标记率及放化纯均大于95％

对影响标记的各种因素作了研究。实验表明

pH对标记的影响很大

直接标记时

EC溶液的pH必须大于10

而配体交换标记时

pH只须大于8;小鼠体内分布

1min肾为14.55％I.D/organ

肾/肝3.39

10min肾为3.11％I.D/organ

肾/肝1.59。小鼠血药动力学研究表明

99m

Tc-EC的血液清除率快

1/2

α为3.9min

1/2

β为39.6min

CL=1.32ml/min。兔γ显像显示

99m

Tc-EC在肾中浓聚高

并经肾脏快速排泄

提示

99m

Tc-EC是一种很有前途的肾功能显像剂。

Abstract

99mTc-EC （L

L ethylenedicystein） is a new renal functional agent. The preparation and its radiochemistry study

animal study were reported in the paper. 99mTc-EC can he easily prepared by two methods

one is direct labelling without boiling

the other is ligand exchange labelling. Labelling yield and radiochemical purity of 99mTc-EC were both better than 95% as confirmed by TLC and HPLC. Study on the influence of labelling conditions on radiochemical purity showed that pH is the most important influence factor: it must be over 10 in direct labelling

but may be as low as 8 for ligand exchange labelling. Renograms in rabbits showed that the T1/2 and Tmax of 99mTc EC are similar to that of131I-OIH. In mice

the biodistribution in kidneys was 14.55 and 3.11 （% I.D/organ） at 1 and 10min postinjection. The simple labelling procedure for 99mTc-EC and its good biological characteristics make it a more practical tracer agent than 99mI-OIH and 99mTc-MAG3 for renal functional study.

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The study of a new renal functional agent of 99mTc-EC

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摘要

Abstract

关键词

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references

The study of a new renal functional agent of ^99mTc-EC