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      • Yifeng Yang,Zhonghao Qian,Changying Jiang,Haozhu Chen
        Vol. 13, Issue 11, (1990)
        摘要：Hemodynamic parameters were assessed before and 0.5h after the p. o. of 20mg of nifedipine (NIF) in 31 patients and 60 mg of diltiazem (DIL) in 24 patients with radionuclide ventriculography. After oraltherapy,NIF improved the LV pumping fucntion, LVEF increased from 0.56 to 0.63 (P<0.001) and LVEDV increased 15 ml/m2 (P<0.01) , CO and CI increased 2.011/min and 1.231/ (min•m2) , respectively, P<0.01. But LV pumping function changed slightly after DIL administration, LVEF and LVEDV increased only 0.03 and 5 ml/m2, respectively, P>0.05. In the group of patients with old myocardial infarction, both negative effect were observed.  
        关键词：Radionuclide ventriculography;Calcium-channel blocker;LV function   
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        发布时间：2022-08-16
      • Baojin Lou,Maosong Jiang,Jiachang Zhou,Side Li,Jinxin Hong
        Vol. 13, Issue 11, (1990)
        摘要：This paper describes the use of 131I labelled antihuman small cell lung cancer (SCLC) monoclonal antibody (2F7) for the treatment of transplanted human SCLC in nude mice. The specific accumulation of the antibody in the transplanted tumors was recorded by both scintigraphic and biodistribution studies. Administration of 131I-2F7 inhibited tumour growth when compared with control groups (2F7, 131I, and NS) . The results suggested that monoclonal antibody 2F7 might have potential clinical application in tumour localization and targeting therapy.  
        关键词：Monoclonal antibody;Human small cell lung cancer;Radioimmunoimaging;Radioimmunotherapy   
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        发布时间：2022-08-16
      • Aina Yuan,Huiyang Zhao,Guanlin Zhao,Zhiying Wang,Junren Zhu
        Vol. 13, Issue 11, (1990)
        摘要：The therapeutic effects of regional cerebral ischemia using sequential external counterpulsation are evaluated in this paper by brain perfusion SPECT with 99mTc- (d, l) HM-PAO or 99mTc-ECD, which is well known as a noninvasive, sensitive, quantitative, three dimensional diagnosis method for brain diseases according to the region and degree of ischemia.  
        关键词：Brain perfusion SPECT;Regional cerebral ischemia;Sequential external counterpulsation;Ischemic penumbra   
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        发布时间：2022-08-16
      • Hui Wang,Chengmo Zhu,Jixian Zhang
        Vol. 13, Issue 11, (1990)
        摘要：In this study, an attempt was made to evalute the clinical value of phase analysis in preexcitation syndrome. The first Fourier harmonic of time-curve in each pixal was computed and displayed as amplitude image, phase image, phase distribution histogram and cinephase image. In 12 patients with preexcitation syndrome, three types are confirmed by EKG: B type (8 cases) , A type (3 cases) and Concealed type (1 case) . In 8 cases of B type, the MRV, The ΔEarliest and ΔM (LV-RV) are markedly different from those of normal patients. By the quantitative and quantitative analysis, the phase changes in right ventricule is earlier than those in left ventricule. In 3 cases of A type, the phase image in 2 cases is correlated with the EKG. While the other one is not. one case of Concealed type is also correlated well with the EKG.In conclution, we think that this method may be very useful for the locatation of preexcitation site, also it has great potential both for the diagnosis and investigation of preexcitation syndrome.  
        关键词：99mTc;Gated blood-poolscintography;Phase image   
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        发布时间：2022-08-16
      • Yingjian Zhang,Changying Jiang,Peng Shao,Hongshi Wang
        Vol. 13, Issue 11, (1990)
        摘要：Fifteen patients with clinical diagnosed thyroid tumor were examined with 99mTc (V) -DMSA and the results were compared with pathologic findings. The lesions of 2 patients with medullary thyroid carcinoma had strong positive uptake and the pattern of radioactive distribution were similar to that of CT scan, Uptake of the other benign and malignant diseases of thyroid were almost negative. The results indicated that the use of 99mTc (V) DMSA would be great clinical value for the diagnosis, localization and follow-up of medullary thyroid carcinoma.  
        关键词：Medullary thyroid carcinoma;99mTc(V) DMSA;Scintigraphy   
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        发布时间：2022-08-16
      • Gaoren Zhang,Shengqing You,Tong Zhu
        Vol. 13, Issue 11, (1990)
        摘要：Lipiodol was labelled with 125I or 131I using an iodine exchange reaction and the stability of the radioiodized lipiodol was measured by chromatography. The optimum reaation condition was found to be 40℃ for 1.5h with acetone as solvent. The labelling efficiency has been found to be 99%. The compound is very stable and no dehalogenation was detected over a one month period.  
        关键词：125I;131I;Lipiodol;Labelling efficiency   
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        发布时间：2022-08-16
      • Ping Fang,Chunying Wu,Qinfang Kuang,Shineng Luo,Yingying Feng,Minhao Xie,Yuefeng Xi,Yuzhi Guo
        Vol. 13, Issue 11, (1990)
        摘要：A new brain perfusion agent 99mTc-ECD (Ethyl-Cysteinate Dimer) and its derivatives MCD, n-PCD, n-BCD, t-BCD, were reported here. ECD and its derivatives were synthesized and identified by IR. NMR. MS and elemental analysis. These compounds could exchange with 99mTc-GH (V) to form stable complexes. The labelling yields were 85-95%. The liposolubility of those 99mTc complexes are in positive correlation with the size of the alkal ester groups, which was confirmed by the partition coefficients and the retention times of HPLC.  
        关键词：Brain perfusion;Imaging agent;99mTc   
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        发布时间：2022-08-16
      • Yuzhi Guo,Tianhao Xie,Qinfang Kuang,Bin Lou,Xinchuan Xu,Keliang Chen
        Vol. 13, Issue 11, (1990)
        摘要：Four 99mTc-labelled dextrans with average molecular weights of 40000,70000, 90000, and 138000 has been evaluated. The study of biodistribution and tracer kinetics in rats demonstrated that, 99mTc-Dx (90) was much better than the others with high uptake of lymph nodes, low penetrating rate from injection site to blood, and excellent target/nontarget organ ratios. The preliminary clinical studies (in 20 normal and 10 patients) were also reported. Following interdigital injection of 0.5—1.0 ml Tc-99m-Dx (90) (about 57MBq) , it reached the knee, inguinal or axilla nodes in 5.0±1.2, 10±2.0, and 15±3.0 min respectively. High quality imagings were obtained in all cases. It is concluded that 99mTc-Dx (90) is a very promising lymph system imaging agent.  
        关键词：Lymph imaging agent;99mTc-Dx;Animal studies   
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        发布时间：2022-08-16
      • Wenzhong Song,Xiangton Lin,Yongchang Liu,Fangping Xue,Honggang Liu,Lianqin Xu,Fengchun Chang,Tong Zhu,Yiguo Zhou
        Vol. 13, Issue 11, (1990)
        摘要：A preliminary evaluation of home produced HM-PAO kit has been made by comparison with ceretec HM-PAO kit. The home made HM-PAO kit is safe, its 99mTc labelling yield being equal to ceretec HM-PAO kit. Its labelled preduct brain uptake, and its SPECT imaging is satisfactory. But the dl HM-PAO content is less than that of ceretec HM-PAO kit.  
        关键词：HM-PAO;Brain imaging;Radiopharmaceuticals   
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        发布时间：2022-08-16
      • Zaixi Cai,Yi Guo,Weifeng Yu,Weiren Zhou,Bo Li,Shirong Tang,Quansheng Wang,Suzhen Jia
        Vol. 13, Issue 11, (1990)
        摘要：The cerebrospinal fluid examination is significant for the diagnosis and differentiation of many nervous system diseases and nervous system complications after some internal diseases, and it also has some referential value for judging curative effect and prognosis. This paper is a description of a multielement analysis on cerebrospinal fluid of non-nervous system diseases patients and sequela of infantile paralysis patients by PIXE. The analysis shows that the detectable elements in cerebrospinal fluid of patients with sequela of infantile paralysis are more than those in patients affected with non-nervous system diseases, the Zn content of the former is lower, and the Pb content of the former is higher than 1ppm. This may be related to early stage diseases.  
        关键词：Cerebrospinal fluid;Trace element   
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        发布时间：2022-08-16
      • Binwei Yu,Nianbao Zhang,Binghua Xie,Ruifang Qin,Desong Zhong,Fuzeng Yao,Haiou Cai,Delong Xu,Huizhen Yu,Zeng Wang
        Vol. 13, Issue 11, (1990)
        摘要：Tritium labelled L-prolyl-L-leucyl-glycinamide (3H-PLG) was prepared by ion beam method and purified by thin-layer chromatogrphy. After removal of all tritum the tritiated tripeptide was obtained with a specific radioactivity of 0.81-1.92GBq/mmol. The radiochemical purity was over 95% and biological activity remained unchanged. The distribution of radioactivity after intraperitoneal injection of 3H-PLG has been studied by direct measurement of radioactivity in different parts brain. The uptake of radioactivity was high in pituitary and striatum and was low in hypothalamus and midbrain.  
        关键词：Tritium labelling of L-prolyl-L-leudyl-glycinamide;Parkinson's disease;Distribution   
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        发布时间：2022-08-16
      • Binghua Xie,Nianbao Zhang,Binwei Yu,Ruifang Qin,Fuzeng Yao,Rongxing Dai,Jun Fang,Jian Huang
        Vol. 13, Issue 11, (1990)
        摘要：In this paper, we discribe technique ——Ion beam tritium labelling method for the preparation of tritium compounds and its use in the tritiation of pachyman. After removal of readlylabile tritium, the tritiated product was obtained with a specific radioactivity of (1.81—2.07TBq/mmol) .The pharmacokinetics study was done in mice using 3H-pachyman urea solution. The blood concentration-time curve obtained after p. o. of 3H-pachyman was shown to fit a two compartment open model.  
        关键词：Tritiated pachyman;Ion beam tritium labelling method;Pharmacokinetics   
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        发布时间：2022-08-16
      • Wei Luo,Zongqin Xia,Hanming Lu,Xuanhai Li,Qianghua Shi,Xinrong Xu,Guanlu Huang,Xiaomou Shi
        Vol. 13, Issue 11, (1990)
        摘要：An isotope dilution method was developed for the simultaneous quantitation of unlabelled and deuterated kynurenine in urine. After a single iv loading dose of (Indole ring-d5) -L-tryptophan, urine excreted in the first 3 hours was collected. Two 10 ml samples from the pooled urine, one with a known amount of unlabelled pure kynurenine added, were purified with an extraction procedure and with cation chromatography. Kynurenine was then derivatized with PFP and analysed with GC-MS.The result showed that the average concentration and the total amount of unlabelled and deuterated kynurenine in the 3 hours urine were significantly decreased in patients with post-hepatitis cirrhosis in comparison with normal subjects, indicating a decrease of tryptophan pyrrolase activity.  
        关键词：Isotope dilution method;Gas chromatography and mass spectroscopy;Deuterated kynurenine in urine;Cirrhosis   
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        发布时间：2022-08-16
      • Fengchun Chang,Tong Zhu
        Vol. 13, Issue 11, (1990)
        摘要：Recent advances in the research of brain radio-imaging agents, including their imaging mechanism and the design of different kinds of imaging agent is reviewed in this paper.  
        关键词：Radionuclide;Brain;Imaging agent;Design   
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        发布时间：2022-08-16
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