Lymphoscintgraphy with <sup>99m</sup> Tc-dextran-comparison of different molecular weight and preliminary clinical studies

Yuzhi Guo; Tianhao Xie; Qinfang Kuang; Bin Lou; Xinchuan Xu; Keliang Chen

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Lymphoscintgraphy with ^99m Tc-dextran-comparison of different molecular weight and preliminary clinical studies

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- Lymphoscintgraphy with ^99m Tc-dextran-comparison of different molecular weight and preliminary clinical studies
- Nuclear Techniques Vol. 13, Issue 11, (1990)
- 作者机构：
  
  江苏省原子医学研究所
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Received：16 February 1989，
  
  Published：01 November 1990
- 稿件说明：
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Yuzhi Guo, Tianhao Xie, Qinfang Kuang, et al. Lymphoscintgraphy with ^99m Tc-dextran-comparison of different molecular weight and preliminary clinical studies[J]. Nuclear techniques, 1990, 13(11): 676-680.
DOI：

Yuzhi Guo, Tianhao Xie, Qinfang Kuang, et al. Lymphoscintgraphy with ^99m Tc-dextran-comparison of different molecular weight and preliminary clinical studies[J]. Nuclear techniques, 1990, 13(11): 676-680. DOI：

摘要

对平均分子量为4、7、9和13.8万的

99m

Tc标记大分子右旋糖酐（Dx）的研究表明

99m

Tc-Dx从注射位置向血液的渗透率，

99m

Tc-Dx在肝、肾等脏器中的浓集随Dx平均分子量增大而降低.而在淋巴结中的药物浓度则随Dx的分子量增大而增加。平均分子量9万的

99m

Tc-Dx在大鼠腘淋巴结与肝、肾、血的放射性浓度之比，在注药后2h分别高达1924、938和6087。完全可以满足淋巴显像的要求。30例

99m

Tc-Dx-90临床试用证明：

99m

Tc-Dx淋巴显像具有显像速度快、图象清晰、非创伤性、使用方便等优点，是一个有前途的淋巴显像剂.

Abstract

Four

99m

Tc-labelled dextrans with average molecular weights of 40000

70000

90000

and 138000 has been evaluated. The study of biodistribution and tracer kinetics in rats demonstrated that

99m

Tc-Dx (90) was much better than the others with high uptake of lymph nodes

low penetrating rate from injection site to blood

and excellent target/nontarget organ ratios. The preliminary clinical studies (in 20 normal and 10 patients) were also reported. Following interdigital injection of 0.5—1.0 ml Tc-99m-Dx (90) (about 57MBq)

it reached the knee

inguinal or axilla nodes in 5.0±1.2

10±2.0

and 15±3.0 min respectively. High quality imagings were obtained in all cases. It is concluded that

99m

Tc-Dx (90) is a very promising lymph system imaging agent.

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Keywords

references

E. Henze et al . , J. Nucl. Med . , 23 （ 1982 ）, 923 .

国毓智等，中华核医学杂志， 4 （ 1984 ）, 4 : 218 .

D. G. Garlick et al . , Am. J. Physiol , 219 （ 1970 ）, 1595 .

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Lymphoscintgraphy with 99m Tc-dextran-comparison of different molecular weight and preliminary clinical studies

DOI：

摘要

Abstract

关键词

Keywords

references

Lymphoscintgraphy with ^99m Tc-dextran-comparison of different molecular weight and preliminary clinical studies