Radioimmunotherapy of human cell lung cancer xenografts in nude mice with <sup>131</sup>I-labelled monoclonal antibody

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Radioimmunotherapy of human cell lung cancer xenografts in nude mice with ¹³¹I-labelled monoclonal antibody

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- Radioimmunotherapy of human cell lung cancer xenografts in nude mice with ¹³¹I-labelled monoclonal antibody
- Nuclear Techniques Vol. 13, Issue 11, (1990)
- 作者机构：
  
  1.上海华东医院
  2.上海市肿瘤研究所
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Received：28 May 1990，
  
  Published：01 November 1990
- 稿件说明：
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Baojin Lou, Maosong Jiang, Jiachang Zhou, et al. Radioimmunotherapy of human cell lung cancer xenografts in nude mice with ¹³¹I-labelled monoclonal antibody[J]. Nuclear techniques, 1990, 13(11): 645-649.
DOI：

Baojin Lou, Maosong Jiang, Jiachang Zhou, et al. Radioimmunotherapy of human cell lung cancer xenografts in nude mice with ¹³¹I-labelled monoclonal antibody[J]. Nuclear techniques, 1990, 13(11): 645-649. DOI：

摘要

本文介绍了

131

I标记抗人小细胞肺癌单克隆抗体（2F

7

）免疫显像及免疫治疗的实验结果。

131

I-2F

7

能与荷瘤裸鼠体内的小细胞肺癌呈特异性结合，使肿瘤清晰显示。与对照组相比，能明显地抑制肿瘤的生长和延长荷瘤裸鼠的存活期。

Abstract

This paper describes the use of

131

I labelled antihuman small cell lung cancer (SCLC) monoclonal antibody (2F

7

) for the treatment of transplanted human SCLC in nude mice. The specific accumulation of the antibody in the transplanted tumors was recorded by both scintigraphic and biodistribution studies. Administration of

131

I-2F

7

inhibited tumour growth when compared with control groups (2F

7

131

I

and NS) . The results suggested that monoclonal antibody 2F

7

might have potential clinical application in tumour localization and targeting therapy.

关键词

Keywords

references

T. Okabe et al . , Cancer Res . , 44 （ 1984 ）, 5273 .

J. Watanabe et al . , Cancer Res . , 47 （ 1987 ）, 826 .

洪锦心等，肿瘤， 6 （ 1980 ）, 248 。

王平等，肿瘤， 6 （ 1988 ）, 246 。

F. Cuttilla et al . , Proc. Natl. Acad. Sci., USA , 78 （ 1981 ）, 4591 .

S. T. Rosen et al . , Cancer Res . , 44 （ 1984 ）, 2052 .

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