Ion beam tritium labelling of L-prolyl-L-leucyl-glycinamide and its distribution in rat brain

Binwei Yu; Nianbao Zhang; Binghua Xie; Ruifang Qin; Desong Zhong; Fuzeng Yao; Haiou Cai; Delong Xu; Huizhen Yu; Zeng Wang

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Ion beam tritium labelling of L-prolyl-L-leucyl-glycinamide and its distribution in rat brain

更新时间：2022-08-16

- Ion beam tritium labelling of L-prolyl-L-leucyl-glycinamide and its distribution in rat brain
- Nuclear Techniques Vol. 13, Issue 11, (1990)
- 作者机构：
  
  1.中国科学院上海原子核研究所
  2.上海第二医科大学附属瑞金医院
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Received：31 July 1989，
  
  Published：01 November 1990
- 稿件说明：
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Binwei Yu, Nianbao Zhang, Binghua Xie, et al. Ion beam tritium labelling of L-prolyl-L-leucyl-glycinamide and its distribution in rat brain[J]. Nuclear techniques, 1990, 13(11): 689-692.
DOI：

Binwei Yu, Nianbao Zhang, Binghua Xie, et al. Ion beam tritium labelling of L-prolyl-L-leucyl-glycinamide and its distribution in rat brain[J]. Nuclear techniques, 1990, 13(11): 689-692. DOI：

摘要

本文用离子束氚标记技术制得氚标记PLG。经硅胶纸层析法纯化，氚化三肽的比活度为0.81GBq/mmol，放化纯度

95%，具有完全的生物活性。由腹腔注射

H-PLG，直接测定大鼠脑内部分组织的放射性分布，提示用药4.5h后，垂体、纹状体有较高的放射性，而下丘脑和中脑的放射性较低。

Abstract

Tritium labelled L-prolyl-L-leucyl-glycinamide (

H-PLG) was prepared by ion beam method and purified by thin-layer chromatogrphy. After removal of all tritum the tritiated tripeptide was obtained with a specific radioactivity of 0.81-1.92GBq/mmol. The radiochemical purity was over 95% and biological activity remained unchanged. The distribution of radioactivity after intraperitoneal injection of

H-PLG has been studied by direct measurement of radioactivity in different parts brain. The uptake of radioactivity was high in pituitary and striatum and was low in hypothalamus and midbrain.

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references

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