A preliminary study on the new brain perfusion imaging agents <sup>99m</sup>Tc-ECD and its derivatives

Ping Fang; Chunying Wu; Qinfang Kuang; Shineng Luo; Yingying Feng; Minhao Xie; Yuefeng Xi; Yuzhi Guo

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A preliminary study on the new brain perfusion imaging agents ^99mTc-ECD and its derivatives

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- A preliminary study on the new brain perfusion imaging agents ^99mTc-ECD and its derivatives
- Nuclear Techniques Vol. 13, Issue 11, (1990)
- 作者机构：
  
  江苏省原子医学研究所
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Received：24 May 1990，
  
  Published：01 November 1990
- 稿件说明：
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Ping Fang, Chunying Wu, Qinfang Kuang, et al. A preliminary study on the new brain perfusion imaging agents ^99mTc-ECD and its derivatives[J]. Nuclear techniques, 1990, 13(11): 670-675.
DOI：

Ping Fang, Chunying Wu, Qinfang Kuang, et al. A preliminary study on the new brain perfusion imaging agents ^99mTc-ECD and its derivatives[J]. Nuclear techniques, 1990, 13(11): 670-675. DOI：

摘要

文章报道了N，N'-乙撑－双（L－半胱氨酸乙酯）（ECD）及其衍生物MCD、n-PCD、n-BCD、t-BCD的合成、放化研究结果。ECD及其衍生物的物理常数和光谱数据与结构一致。ECD及其衍生物与

99m

Tc-GH进行配体交换，能与

99m

Tc（V）生成稳定的络合物，标记率为85-95%，它们的分配系数及HPLC的保留时间证实锝络合物酯溶性大小与酯基的碳原子个数呈正相关。

Abstract

A new brain perfusion agent

99m

Tc-ECD (Ethyl-Cysteinate Dimer) and its derivatives MCD

n-PCD

n-BCD

t-BCD

were reported here. ECD and its derivatives were synthesized and identified by IR. NMR. MS and elemental analysis. These compounds could exchange with

99m

Tc-GH (V) to form stable complexes. The labelling yields were 85-95%. The liposolubility of those

99m

Tc complexes are in positive correlation with the size of the alkal ester groups

which was confirmed by the partition coefficients and the retention times of HPLC.

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references

H. S. Winchell et al . , J. Nucl. Med . , 21 （ 1980 ）, 947 .

H. F. Kung et al . , J. Nucl. Med. 24 （ 1983 ）, 121 .

R. A. Holmes et al . , Nucl. Med. Commun . , 6 （ 1985 ）, 443 .

E. H. Cheesman et al . , J. Nucl. Med. 29 （ 1988 ）, 788 .

S. Ratner and H. T. Clarke , J. Am. Chem. Soc. , 59 （ 1937 ）, 200 .

P. Blondeau et al . , Can. J. Chem . , 45 （ 1967 ）, 49 .

国毓智等．中华核医学杂志， 9 （ 1989 ）, 4 : 213 .

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A preliminary study on the new brain perfusion imaging agents 99mTc-ECD and its derivatives

DOI：

摘要

Abstract

关键词

Keywords

references

A preliminary study on the new brain perfusion imaging agents ^99mTc-ECD and its derivatives