最新刊期
      卷 0 ， 期 0 ， 2020
      • XIE Changqing CHEN Dapeng LI Bing YE Tianchun
        Issue 5, (2004)
        摘要：Compared to other Next Generation Lithography ( NGL) techniques, X-ray lithography has many ad- vantages, such as large process latitude, high throughput, extremely long depth of focus, large exposure field sizes, and low cost, and the more important thing is that X-ray lithography technology is relatively mature. For 100 nm resolution synchrotron radiation X-ray lithography system, its wavelength is in the range of 0.7—1.0 nm; and when the resolution is below 50 nm, its wavelength should be in 0.2 nm to 0.4 nm. In this paper, the possibility of designing a 50 nm resolution X-ray lithography system for Beijing Synchrotron Radiation Facility 3B1A beamline is discussed.  
        关键词：X-ray lithography;Synchrotron radiation;Beam propagation method;Lithography resolution   
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        发布时间：2021-03-12
      • XU Ruinian LI Deming
        Issue 5, (2004)
        摘要：Application of the high-capability MCU in the intelligent interface is introduced in this paper. A prototype of intelligent interface for high precision huge magnet power supply was developed successfully. This intelligent interface was composed of two parts: operation panel and main board, both of which adopt a MCU of PIC16F877 respectively. The interface has many advantages, such as small size, low cost and good interference immunity.  
        关键词：Intelligent interface;MCU;High precision;Magnet power supply   
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        发布时间：2021-03-12
      • WU Xiaoshan XU Jin CAI Hongling ZHANG Aimei JIANG Shusheng
        Issue 5, (2004)
        摘要：By off-set rf-magnetosputtering technique, we have fabricated La2/3Ca1/3MnO3 (LCMO) films on SrTiO3 ( STO ) , Yttrium stabilized ZrO2 ( YSZ ) and sapphire ( ALO ) substrates. A metal-insulator transition was observed for samples with the thickness is larger than 200?, the transition temperature, TMI varies with the substrate and the thickness of LCMO. A percolation model was used to fit the temperature dependence of resistance for all films. In combining with the epitaxial process, the interaction between the film and substrates, and the results for sur- face and interface roughness of the films, we argue that the surplus resistance of the films, the active energy of the polaron, and the metal-insulator transition temperature are strongly related to the quality of the films.  
        关键词：La-(2/3)Ca-(1/3)MnO-3 thin films;Substrate effects;Interfacial roughness;Lattice mismatch.   
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        发布时间：2021-03-12
      • LIU Xianghuai1,3 ZHU Hong1 REN Congxin1 ZHENG Zhihong1 XU Jingfang2 CHEN Shude3 1
        Issue 5, (2004)
        摘要：Electron emission from grid is a serious problem for it limits the service time and destroys the working condition of the traveling wave tubes. After coating carbon films on the surface of the control grid by ion beam en- hanced deposition (IBED) in our laboratory, the electron emission from control grid was suppressed. One of the trav- eling wave tubes with control grid treated with coating carbon film already had a service time more than 1000 h. This technology has already been used in defense and aviation field successfully. The preparation and properties of two kinds of carbon films-diamond like carbon and graphite like carbon, their applications and mechanism for suppression of electron emission are presented in this paper.  
        关键词：Ion beam enhanced deposition;Carbon films;Suppression of electron emission   
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        发布时间：2021-03-12
      • WEI Mengfu ZHANG Lianping JIANG Guoqiang WEI Yanbo QI Honglian WU Lunqiang
        Issue 5, (2004)
        摘要：In order to apply HPGe gamma spectroscopy to estimate hold-up in radioactive waste pipes, it is necessary to study absolute efficiencies of the detector for known source distribution. Depending on the principle of Monte Carlo simulation of photon transport, we have calculated the energy deposition in cylindrical HPGe crystals, self-absorption absorption by materials on transport ways and geometrical factors for known source distribution. A comparison between experimental data with calculated results, shows that the uncertainty is less than 10%.  
        关键词：Monte Carlo simulation;Radioactive matter;Hold-up;Absolute efficiencies   
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        发布时间：2021-03-12
      • LI Lei XIA Weidong ZHAO Yuhan
        Issue 5, (2004)
        摘要：A new method for glidarc discharge driven by magnetic field at atmospheric pressure has been used to generate non-equilibrium plasmas. The setup of glidarc discharge is described and the principle of glidarc discharge is analyzed. The arc’s moving speed is about 100 m/s and the electric field is 80 V/mm at an arc current of 0.6A.  
        关键词：Non-equilibrium plasma;Atmospheric pressure;Gliding arc;Magnetic field   
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        发布时间：2021-03-12
      • HUANG Biao1,2 ZHANG Xiangrui1 ZHU lan1 MO Zhonggen3 YANG Yaoqin3 ZHAO Xintai3 1
        Issue 5, (2004)
        摘要：The aim of this work is to provide an accurate and scientific method of radionuclide imaging for small cell lung cancer with Tcm-2F7 F (99ab′ ) 2 . The monoclonal antibody 2F7 F (ab′ ) 2 segment was derived by iminothiolane and ligand exchange from Tcm O ( GH ) 99? 2 . Labeling efficiency was measured by paper chromatography. The label- ing efficiency of the labeled antibody 2F7 F ( ab′ ) 2 was 93.5%,with 2.5% colloidal Tcm in it. The competition test in 99 vitro showed that Tcm bound with the high affinity sites of antibody. The stability of the iminothiolane modified 99 antibody 2F7 F ( ab′ ) 2 could be kept at 4℃ for 3 months. In conclusions, the labelling method applied to the preparation of 99Tcm labeled antibody 2F7 F ( ab′ ) 2is successful, and appears to be equally applicable to other antibodies.  
        关键词：Small cell lung cancer;Monoclonal antibodies;Radioimmunoimaging   
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        发布时间：2021-03-12
      • LI Peiyong JIANG Xufeng WANG Hui CHEN Gang ZHANG Liying WANG Chao LI Biao ZHU Chengmo
        Issue 5, (2004)
        摘要：FDG PET imaging was performed 32 cases of papillary (n = 18 ) and follicular ( n = 14 ) thyroid carcinoma after thyroidectomy. In order to evaluate the influence of serum TSH level on results of 18FDG PET imaging, the patients were divided into two groups with under TSH suppression ( TSH≤0.3μIU/mL ) and without TSH suppression ( TSH > 0.3 μIU/mL ) , respectively. The uptake levels of FDG in recurrent or metastatic lesions in 18 two groups were compared by SUV and the tumor-to-background ratios ( TBRs ) . Fourteen of 32 patients had positive FDG PET imaging with 6 and 8 patients in under TSH suppression group and without TSH suppression 18 group, respectively. The difference between two groups didn’t reached significance ( χ2 = 1.814, P = 0.178 ) . 3 recurrent patients within under TSH suppression group and proved by clinical follow up had false negative of FDG 18 PET imaging. Total 24 metastatic lesions were found and analysed by SUV and TRBs. The uptake level of FDG in 18 lesions of without TSH suppression group was higher than under TSH suppression group. Statistical study showed that the difference between two groups has reached significant level ( P < 0.05 ) . This study demonstrated that serum TSH level could influence the uptake of FDG in recurrent or metastatic lesions of differentiated thyroid carcinoma. 18  
        关键词：Positron emission tomography;Thyroid stimulating hormone;Thyroid carcinoma   
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        发布时间：2021-03-12
      • LI Yusheng WANG Xufu YU Suqing YU Yunyun YANG Liting
        Issue 5, (2004)
        摘要：To evaluate the clinical value of portal-systemic shunt by the study on apiece time H/L ratio imaging in hepatocirrhosis, administration of Tcm-MIBI per rectum was performed in 10 healthy subjects and 36 patients with 99 cirrhosis by calculating H/L ratio and SI within 7 periods in 15—240 min to analyze the degree of hepatocirrhosis as- sociated with portal-systemic shunt. We have found that there is a marked difference between the H/L ratios of the control group and of the hepatocirrhosis group A, B, C ( t = 15.87, 11.76, 16.11, P < 0.001 ) , and there is a good cor- relation between H / L ratio and SI ( r = 0.926, P < 0.001 ) . It is concluded that this is a safe method for evaluating portal-systemic shunt and thus helping obtain diagnostic index by estimating the degree of hepatocirrhosis and portal tension.  
        关键词：Portal cirrhosis;Per rectal portal-scintigraphy;Portal-systemic shunt;Apiece time ratio of H/L;99Tcm-MIBI   
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        发布时间：2021-03-12
      • LIU Sheng LIU Changzheng LIANG Biling LIANG Changsheng JIANG Ningyi 1
        Issue 5, (2004)
        摘要：To establish a method for directly labeling antisense oligonucleotide ( ASON ) with iodine and evaluate the stability and biodistribution of labeled ASON, 15mer bcl-2 ASON to mRNA was labeled with iodine by Iodogen, purified with Sephadex G-25. Labelling efficiency and purity of labeled ASON were measured, and the stability was evaluated. Biodistribution of labeled ASON was studied in BALB/c nude mice and CNE2 bearing mice. Results showed that 1) The Labelling efficiency was 85% under suitable conditions and radiopurity was 90%, and specific radioactivity was 4.77 × 105Bq/ μ g ( ASON ) . 2) The labeled ASON was stable at room temperature, but disintegrated partly in fresh serum. 3) The radioactivity of labeled ASON decreased fast in most of organs, presenting a two-phase distribution. The uptakes of radioactivity in thyroid gland and gastrointestine were obvious, indicating labeled ASON were not stable. Tumor tissues had little ASON uptake, and immunohistological test confirmed that the expression of bcl-2 in CNE2 was very low. These findings indicated that directly iodine labeling ASON with Iodogen was simple and reliable, and it could provide high labelling efficiency, high specific activity and stable labeled ASON. But stability of labeled ASON was poor in vivo due to disintegration of nucleotidase.  
        关键词：bcl-2 antisense oligonucleotide;Iodine-125;Stability;Biodistribution   
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        发布时间：2021-03-12
      • MAYubo HUANG Gang KANG Xiangdong LIU Yiwen LU Ping CHEN Meijuan
        Issue 5, (2004)
        摘要：To study and compare the clinical curative effect of extremity verruca with 32P and laser and their application values, 229 patients with extremity verruca were chosen by random from outpatient. Out of them, 83 patients were male and 146 were female, with the average age of 34.6 ± 19.5 ( x ± s ) years. They were randomly divided into two groups: for the laser treatment group consisting of 127 individuals, the wart bodies were eliminated by CO2 laser under local anaesthetization, if there were a lot of locus, the wart bodies were treated in turn. 102 individuals were treated with 32 P application therapy. The liquid containing radionuclide P was dropped on filter 32 papers, dried and then fixed on the corresponding focus surface for application therapy, applying 4—8 hours continuously ( the absorbed dose at the lesion surface reaching 984—1968 cGy) each time and once a week until the lesion recovered. The clinical reaction and curative effect were observed. The clinical effective rate, cure rate, recurrence rate, side effective rate occurrence rate and complication occurrence rate for the laser treatment group are 100%, 55.9%, 44.1%, 17.3% and 25.2%, respectively while they are 100%, 91.2%, 5.9%, 19.6% and 7.8% respectively for the group of P application therapy. It is concluded that the treatment of extremity verruca with P 32 32 application therapy is a simple and effective method with features such as safety, little pain, notable curative effect, lower recurrence rate, less side effect and complication.  
        关键词：Verruca;Laser;32P;Application therapy;Radiation dosage   
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        发布时间：2021-03-12
      • LIU Jianjun HUANG Gang SHI Yiping YUAN Jimin ZHU Cuiying XU Qing
        Issue 5, (2004)
        摘要：To study the value of F-FDG coincidence imaging in diagnosis of cancer, 101 patients who were suspi- 18 cious of cancer were F-FDG coincidence imaged before operation. Diagnoses of visual and semi-quantitative analy- 18 sis were compared with the pathologic results after operation. The sensitivity and speciality of F-FDG coincidence 18 imaging were 84.61% and 78.26% in detecting cancer, while accuracy was 83.1%. For patients with a cancer of less than 2 cm, the sensitivity and speciality were 80% and 100%, accuracy was 82.35%. When standard of diagno- sis was higher than 2.0 in T / N value, the sensitivity and speciality were 85.90% and 82.61%, while accuracy was 85.15%; when visual analysis was combined with semi-quantitative analysis, the sensitivity and speciality were 88.5 % and 87.0%, while accuracy was 88.11%. In conclusion, it is of higher value to diagnose cancers with F-FDG 18 coincidence imaging, and the accuracy of diagnosis can be improved by visual analysis combined with semi-quantitative analysis.  
        关键词：18F-FDG;Coincidence imaging;Cancer   
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        发布时间：2021-03-12
      • LIU Yongbiao1,2 MEI Kai2 LIU Ying2 ZHAO Jie2 ZHANG Xianwen2 ZHOU Qiang2 HAO Xingzhi2 YAO Side1 1
        Issue 5, (2004)
        摘要：A study was carried out on effects of IL-6 on the proliferation and apoptosis of tumor cells and the ex- pression of apoptosis relavent genes ( p53,bcl-2 ) in tumor cells for three kinds of fractional total-body-irradiated tu- mor-bearing mice.The apoptotic index, proliferative index , S phase fraction of S180 sarcoma, H22 hepatocarcinoma and Lewis lung cancer cells were measured by flowcytometry ( FCM ) after total-body-irradiation and irradiation plus IL-6. The protein expression level of p53, bcl-2 in three kinds of tumors were also determined by the immunohisto- chemical method ( UltraSensitive S-P ) . The results showed that the S phase fraction and proliferation index in Lewis lung cancer cells were lower in the irradiated plus IL-6 group than in the control, while apoptotic index was higher ( P < 0.05). However, the experimental results for S180 sarcoma cells were opposite ( P < 0.01 ) . In addition, no significant effects were observed in H22 hepatocarcinoma. These results revealed that IL-6 promoted the apoptosis of irradiated Lewis lung cancer cells ( P < 0.05 ) , while the apoptosis of S180 sarcoma ( P < 0.05 ) was restrained, and there was no significant effects on the cellular cycle of H22 hepatocarcinoma (P > 0.05 ) . In Lewis lung cancer the expression level of p53 was lower in the IL-6 group and highter in S180 sarcoma ( P < 0.05 ) , while unvaried in H22 hepatocarcinoma as compared to the control ( P > 0.05 ) . It is considered that tumor cell’s proportion in the cellular cycle is changed by IL-6 and the effects of IL-6 on the expression of p53, bcl-2 in different three kinds of tumors are different. IL-6 has radio-sensitive effects on some tumors and opposite effects on other tumors, it may be related to the expression of P53 and Bcl-2 in tumor cells.  
        关键词：Interleukin-6;Tumor;Ionizing radiation;Proliferation;Apoptosis;p53;bcl-2   
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        发布时间：2021-03-12
      • ZHOU Wei1 YIN Duanzhi1 ZOU Hao1 HU Weiqing1 CHEN Minfeng2 ZHANG Lei2 HE Weiyu1 MIN Xiaofeng2 XU Jianying2 CUI Haiyan1 WANG Yongxian1 1
        Issue 5, (2004)
        摘要：The analytical method for main components HEDP and SuCl2 of 188Re ( Sn ) -HEDP kit was established. According to Chinese Pharmacopoeia, stability of 188 Re ( Sn ) -HEDP kit was also investigated, including the tests for influencial factors ( high illumination, high temperature and high humidity) and the test for validity period under low temperature. The stability study is based on the determination of labeling yield as well as contents of HEDP and SnCl2·2H2O, and on the bacteria test and endotoxin test.  
        关键词：188Re（ Sn ） - HEDP kit;Quality;Stability   
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        发布时间：2021-03-12
      • ZHANG Xiuli WANG Yongxian LI Junling YIN Duanzhi
        Issue 5, (2004)
        摘要：Polyazamacrocyclic compounds, a group of effective bifunctional chelating agents, have been applied in radio-metals labeling peptides, protein and monoclonal antibodies. Those biomolecules with labeled radio-metals are hopeful of becoming raiopharmaceuticals for radiodiagnosis and radiotherapy. Recent progress in the application of polyazamacrocyclic compounds in radio-metals labeling is summarized. This paper introduces polyazamacrocyclic compounds and, radionuclides used in the radio-metals labeling, and biological characters of the labeled conjugates. Both advantages and disadvantages of polyazamacrocyclic compounds in the labeling with different radionuclides are discussed.  
        关键词：Polyazamacrocyclic compounds;Radio-metals;Labeling;Bifunctional chelating agent   
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        发布时间：2021-03-12
      • FANG Fang HOU Xinsheng MAYingjie ZHU Jingliang JIA Wenyi ZHOU Rongsheng
        Issue 5, (2004)
        摘要：The low energy γ-ray spectrum is described in detail on the basis of analyzing the field full γ spectrum. The relationship is discussed between low energy γ spectrum and effective atomic number of rocks. Since there are differences in the position and shape of the low energy spectrum for different rocks, the lithology of rocks can be differentiated by means of measuring the low energy gamma ray spectrum.  
        关键词：Low energy γ spectrum;Field γ spectrometry;Lithology   
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        发布时间：2021-03-12
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