Polyazamacrocyclic compounds

a group of effective bifunctional chelating agents

have been applied in radio-metals labeling peptides

protein and monoclonal antibodies. Those biomolecules with labeled radio-metals are hopeful of becoming raiopharmaceuticals for radiodiagnosis and radiotherapy. Recent progress in the application of polyazamacrocyclic compounds in radio-metals labeling is summarized. This paper introduces polyazamacrocyclic compounds and

radionuclides used in the radio-metals labeling

and biological characters of the labeled conjugates. Both advantages and disadvantages of polyazamacrocyclic compounds in the labeling with different radionuclides are discussed.