最新刊期
      卷 0 ， 期 0 ， 2020
      • YAN Xuexian,LI Shaolin
        Issue 5, (1999)
        摘要：The methods to prepare instant kit of 99mTc(V)-DMSA were evaluated and optimized. Various conditions and procedures were taken to prepare and label the kit. The physico-chemical properties and biodistribution of the labelling compound were tested in order to select the optimal condition. Each kit contains 0.55mg DMSA and 0.1mg SnCl2. An aliquot of 1.0-10mL 99mTcO4 was mixed with the kit for labelling, and a radiochemical purity of ≥95% was then reached. The biodistribution ratios of tumor/liver and tumor/blood are 2.5 and 2.2 respectively in tumor bearing mice.  
        关键词：mTc;Dimercaptosuccinic acid;Kit;Nuclide imaging   
        9
        |
        49
        |
        1
        <HTML>
        <L-PDF><Meta-XML>
        <引用本文> <批量引用> 7200109 false
        发布时间：2021-03-12
      • SHEN Qinyan,HUANG Qun
        Issue 5, (1999)
        摘要：In order to explore the optimal store condition and calculate the shelf life of methoxy isobutyl isonitrile (MIBI) for injection. The stability of formamidinesulfinic acid (FSA) in methoxy isobutyl isonitrile(MIBI) for injection was studied. FSA is determined by indirect iodometry analysis. The recovery was 98.0%-102.4%. Temperature and light are the major influence factors. Acceleration test showed that the degradation reaction was a first-order reaction. The activation energy E was 84.53kJ/mol. It was estimated that the shelf life of MIBI for injection kept in refrigerator might be longer than 13.7 months.  
        关键词：Methoxy isobutyl isonitrile for injection;Indirect iodometry;Formamidinesulfinic acid;Stability   
        8
        |
        42
        |
        0
        <HTML>
        <L-PDF><Meta-XML>
        <引用本文> <批量引用> 7201443 false
        发布时间：2021-03-12
      • ZHANG Junbo,WANG Xuebin
        Issue 5, (1999)
        摘要：mTcN(NOEt)2 is prepared through a two step ligand-exchange reaction by using SnCl2 as reduction agent and SDH (succinyl dihydrazide) as a donor of nitride nitrogen atom (N3-) at room temperature. The labelling procedure is more convenient for clinical use. The radiochemical purity (RCP) of the product is over 90% by TLC. The biodistribution results in mice indicate that 99mTcN(NOEt)2 has high myocardial uptake. For 5 min post injection the heart-to-blood, heart-to-liver and heart-to-lung ratios are 10.48, 2.07 and 0.74, respectively. The uptake of brain is also good. For 5min post injection the brain uptake is 4.43%ID·g-1 and the brain-to-blood ratio is 1.12. Based on these results 99mTcN(NOEt)2 exhibits prommising properties for further studies.  
          
        8
        |
        37
        |
        7
        <HTML>
        <L-PDF><Meta-XML>
        <引用本文> <批量引用> 7201348 false
        发布时间：2021-03-12
      • MIAO Yubin,HE Qiange,LIU Boli
        Issue 5, (1999)
        摘要：In order to find new 99mTcN complexes for myocardial perfusion imaging, a new N2S2 ligand of N,N’-bis(2-mercapto-propyl)- 1,2-benzenediamine (BMPBDA) has been synthesized and its 99mTcN complex has been prepared by using SnCl2 as reductant. The effect of pH on RCP has been investigated. In the biodistribution study of 99mTcN-BMPBDA in mice, high myocardial uptake and rapid clearance from blood were demonstrated. After i.v. administration, 24.53%ID·g-1 of 99mTcN-BMPBDA was extracted into heart at 2 minutes. However, the residence time of 99mTcN-BMPBDA in heart was not long, 7.97%ID·g-1 of 99mTcN-BMPBDA retained in heart 30 minutes after injection. The activity clearance from blood is rapid and the clearance half-life is less than 15 minutes, but the activity level in blood is high. This study may be valuable for the design of new 99mTcN complex for myocardial perfusion imaging.  
        关键词：Myocardial perfusion imaging;99mTcN-BMPBDA;SnCl2 as reductant   
        9
        |
        33
        |
        1
        <HTML>
        <L-PDF><Meta-XML>
        <引用本文> <批量引用> 7200086 false
        发布时间：2021-03-12
      • WANG Hui,ZHANG Jixian,CHENG Zhongyuan,TIAN Weijia,PAN Zhilai,PU Mingfang,FENG Guowei,CHEN Gang,ZHU Chengmo
        Issue 5, (1999)
        摘要：In this study, the results of 99mTc-tetrofosmin SPECT and CT were directly compared with surgical findings for evaluating the lung and mediastinal lymph node lesions in 32 patients with lung masses, among them 16 squamous cell carcinoma, 8 adenocarcinoma, 4 small cell carcinoma, 2 metastatic lung lesions and 2 tuberculoses. For lung lesions, 99mTc-tetrofosmin SPECT showed higher sensitivity (93%, 28/30), but with two false positive TB lesions. Besides in 5 patients with tumor central necrosis, 99mTo-tetrofosmin SPECT showed central activity defect comfirmed by operation. For mediastinal lymph node lesions, 99mTc-tetrofosmin SPECT has better sensitivity and specificity (88% and 87%) than CT scan (59% and 67%). Thereby, 99mTc-tetrofosmin SPECT was an accurate and effective method in evaluating the lung cancers and mediastinal lymph node metastases especially for the latter ones.  
        关键词：mTc-tetrofosmin;SPECT imaging;Lung cancers   
        7
        |
        35
        |
        0
        <HTML>
        <L-PDF><Meta-XML>
        <引用本文> <批量引用> 7201368 false
        发布时间：2021-03-12
      • CHEN Wenxin,DONG Weiyu,HE Pinyu,LIU Yonghua,LIU Yuzhen
        Issue 5, (1999)
        摘要：The 99mTc-DTPA dynamic renography was performed in 35 normal controls and 47 patients with DM. Dual energy X-ray absorptiometry (DEXA) was used to estimate bone mineral density in L2-L4 for all of the cases. The results showed that BMD age-matched values of subgroups with mild or severe decreasing renal function were significantly lower than that of the controls (P<0.05 and P<0.01, respectively). And, BMD decreased more significantly for the subgroup with severe decreased renal function. Therefore, the prophalaxis of osteoporosis for DM patients with renal insufficiency is very important, and the protection of renal function of DM patients is effective for the prevention of diabetic osteoporosis.  
        关键词：Diabete melltus;Dynamic renography;Bone mineral density   
        8
        |
        38
        |
        1
        <HTML>
        <L-PDF><Meta-XML>
        <引用本文> <批量引用> 7200118 false
        发布时间：2021-03-12
      • ZHAO Jun,SUN Qiyin,LI Jiamin,WANG Mingfang,SUN Aijun,WU Jinling,LI Na
        Issue 5, (1999)
        摘要：The purpose of this study was to assess the value of whole body 18F-FDG PET imaging in the diagnosis of bone metastases in patients with various tumors. Fifty two patients with various tumors underwent whole body 18F-FDG PET imaging and bone scintigraphy simultaneously. The diagnoses of bone metastases were based on histological findings, or the other imaging modalities such as CT, MRI and the clinical follow-up study. Altogether 106 bone metastases were detected in 52 patients. The sensitivity of bone scintigraphy and FDG PET for detecting bone metastases were 89.6% and 63.2% respectively. The sensitivity of PET is lower for detecting the metastases in ribs and skull, and the accurate location of lesions have some difficulty if assessed by PET imaging only. In conclusion, the diagnosis of bone metastases should be cautious by whole body 18F-FDG PET imaging, and it is essential to evaluate in combination with 99mTc-MDP bone scintigraphy.  
        关键词：Secondary bone neoplasms;Radionuclide imaging;Deoxyglucose   
        18
        |
        72
        |
        4
        <HTML>
        <L-PDF><Meta-XML>
        <引用本文> <批量引用> 7200141 false
        发布时间：2021-03-12
      • LIU Fangyan,ZHOU Meiying,YIN Linxiang,YANG Jianzhong,HUA Chenglin
        Issue 5, (1999)
        摘要：Using double-antibody coated tubes, a solid-phase radioimmunoassay for free thyroxine (FT4) in serum has been developed. The antibody immobilized onto the surface of the coated plastic tubes competed for binding with FT4 or 125I labelled T4-analogue. Whole test was completed within 2h. The detectable range was 0.12 to 75pmol/L FT4 in serum. The mean coefficients of variation within and between assays were 1.7%-4.4% and 3.2%-9.1%, respectively. The non-specific binding was less than 1%. This new assay was compared with a commercial radioimmunoassay kit for FT4 (labelled antibody). A linear regression analysis yielded a slop of 1.08, an intercept of 2.3 and a correlation coefficient of 0.85. Most of the analytical indices are better than the routine RIA procedure. Therefore it appears to be a simple, precise and accurate new assay method.  
        关键词：Free thyroxine (FT4);Double-antibody coated tube;Solid-phase radioimmunoassay   
        10
        |
        59
        |
        1
        <HTML>
        <L-PDF><Meta-XML>
        <引用本文> <批量引用> 7200098 false
        发布时间：2021-03-12
      • MIN Xiaofeng,ZHANG Jiong,YU Junfeng,YIN Duanzhi,GUO Zili,WANG Yongxian
        Issue 5, (1999)
        摘要：The 188Re-sulfide suspension was injected into sarcoma mice interstitially. The result showed that the ratio of uptake of sarcomas was about 80%-90%, and the growth of sarcoma was depressed in all mice. When 21.2MBq 188Re-sulfide suspension were injected twice in each mouse, no any toxic effect was found. The white blood cells(WBC) in mice injected with 188Re-sulfide suspension was less than those of the other groups, but still within the normal level. No significant effect to the bone marrow was observed.  
        关键词：Re-sulfide;Suspension;S-180 sarcoma   
        9
        |
        30
        |
        4
        <HTML>
        <L-PDF><Meta-XML>
        <引用本文> <批量引用> 7201282 false
        发布时间：2021-03-12
      • MO Shangwu,ZHANG Zuokiu,YUAN Pengfei,DU Xing,WU Yurong
        Issue 5, (1999)
        摘要：The Pogostemon cablin Benth(PCB) and Eupatorium fortunei Turez(EFT) belong to the groups of complex prescription " Yu-Geng-Tong-Yu decoction". The separation of the effective component was taken by n-hexane, chlorofrom, methanol and water respectively, and the Ca2+ antagonistic effect was determined by 45Ca transmembrane influx technique. It was found that the extract separated by silica gel chromatography and eluted by n-hexane have seven functional fractions. Among them, the dark-green fraction of PCB and the orange fraction of EFT have strongest activity of Ca2+ antagonistic effect.  
        关键词：Coronary artery disease;Ca2+ antagonist;45Ca;Huoxiang;Peilan   
        11
        |
        172
        |
        2
        <HTML>
        <L-PDF><Meta-XML>
        <引用本文> <批量引用> 7201250 false
        发布时间：2021-03-12
      • CHENG Wei,DENG Shouzhen,LIN Xiangtong
        Issue 5, (1999)
        摘要：Free and total prostate specific antigen (F-PSA and T-PSA) in serum were measured with immunoradiometritic assay and the F/T-PSA ratio was calculated in 175 patients with T-PSA levels in the range of 4-20 μg/L. Among them 141 patients were benign prostatic hyperplasia (BPH), 23 were untreated prostate cancer (Pca untreated) and 11 were treated prostate cancer (Pca treated). The results showed that difference in F-PSA and F/T-PSA ratio for BPH group and Pca untreated group were statistically significant (P<0.01). The effectiveness of F/T-PSA ratio for Pca (89.9%) was higher than F-PSA (54.8%). The receiver-operating characteristic (ROC) curve showed an improved diagnostic efficacy of F/T-PSA ratio compared with T-PSA for discrimination between BPH and Pca. If mean F/T-PSA ratio value+ 1SE (13.2%) was used in BPH group as discrimination limits of Pca patients, the diagnostic accuracy of BPH group and Pca untreated group were 90.8% and 82.6% respectively. Thereby F/T-PSA ratio may be useful for the differentiation between BPH and prostate cancer.  
        关键词：Benign prostatic hyperplasia;Prostate cancer;Free prostate specific antigen;Total prostate specific antigen;Free to total prostate specific antigen ratio   
        10
        |
        42
        |
        4
        <HTML>
        <L-PDF><Meta-XML>
        <引用本文> <批量引用> 7201692 false
        发布时间：2021-03-12
      • SONG Shiping,TANG Guozhong
        Issue 5, (1999)
        摘要：A conjugate is formed of avidin(Av) and bovine serum albumin(BSA) through coupling reagents and this conjugate is bound to surface of support. Then, a sensitive, specific, competitive or noncompetitive immunoassay can be performed on the support. The experiments proved that this solid-phase avidin has good stability in RIA and can be used for automation of immunoassay.  
        关键词：Solid-phase avidin;Biotin-avidin system;Radioimmunoassay   
        9
        |
        65
        |
        1
        <HTML>
        <L-PDF><Meta-XML>
        <引用本文> <批量引用> 7200215 false
        发布时间：2021-03-12
      • ZHU Shoupeng,XIAO Dong,HAN Xiaofeng
        Issue 5, (1999)
        摘要：It was found that bone sarcoma cell nuclei after irradiated with 153Sm-EDTMP, displayed a significant nuclear fragmentation and a marked pyknosis. At the same time, the inhibition effect of proliferation in bone sarcoma cells after internal exposure with radionuclide 153Sm was also observed. With the prolongation of internal exposure time by 153Sm-EDTMP, the inhibition rate of proliferation in bone sarcoma cells increased progressively.  
        关键词：Sm-EDTMP;Bone sarcoma cells;Apoptosis;Fluorescence microscopy;Inhibition rate of proliferation   
        9
        |
        49
        |
        3
        <HTML>
        <L-PDF><Meta-XML>
        <引用本文> <批量引用> 7200129 false
        发布时间：2021-03-12
      • ZHU Jianhua,ZHONG Gaoren,GONG Jialing,ZHU Tong
        Issue 5, (1999)
        摘要：The most available positron radionuclide labeled radiopharmaceuticals for clinical diagnosis are the compounds labelled with 18F, 11C, 15O and 13N which have short half-life. This review described the syntheses and clinical use of the short half-life positron radionuclide labelled radiopharmaceuticals, especially 18F and 11C labelled compounds.  
        关键词：Positron radionuclide;Radiopharmaceuticals;18F;11C   
        10
        |
        170
        |
        7
        <HTML>
        <L-PDF><Meta-XML>
        <引用本文> <批量引用> 7201727 false
        发布时间：2021-03-12
      • HUANG Tiansen
        Issue 5, (1999)
        摘要：The research and manufacture of radiopharmaceuticals in China were begun in 1961. Following that year, the control cause of radiopharmaceuticals was also begun. Through the endeavour of more than thirty years, the quality standards of radiopharmaceuticals suitable for our country were formed, the level of quality standard gradually elevated and the drug quality assured reliably. Under the leadership of the Ministry of Public Health, a quality assurance system for radiopharmaceuticals was strengthened and perfected. This system consisted of control agencies of radiopharmaceutical which was authorized by the Ministry of Public Health and of testing departments of manufacturing units. The development of the control cause of radiopharmaceutical has strongly promoted the advances of both radiopharmaceuticals and nuclear medicine.  
        关键词：Radiopharmaceuticals;Cause of drug control   
        8
        |
        74
        |
        1
        <HTML>
        <L-PDF><Meta-XML>
        <引用本文> <批量引用> 7201308 false
        发布时间：2021-03-12
      0