An improved labelling method on <sup>99m</sup>TcN（NOEt）<sub>2</sub> and its biodistribution

ZHANG Junbo; WANG Xuebin

doi:null

您当前的位置：

首页 >

文章列表页 >

An improved labelling method on ^99mTcN（NOEt）₂ and its biodistribution

更新时间：2021-03-12

- An improved labelling method on ^99mTcN（NOEt）₂ and its biodistribution
- NUCLEAR TECHNIQUES Issue 5, (1999)
- 作者机构：
  
  北京师范大学,北京,100875
- 作者简介：
- 基金信息：
- DOI：
  CLC： R917
- Published：01 May 1999
- 稿件说明：
移动端阅览
[1]张俊波,王学斌.一种改进的~(99m)TcN(NoEt)_2的标记方法及其生物分布[J].核技术,1999(05):268-270.

ZHANG Junbo, WANG Xuebin. An improved labelling method on ^99mTcN（NOEt）₂ and its biodistribution[J]. Nuclear techniques, 1999, (5): 268-270.
[1]张俊波,王学斌.一种改进的~(99m)TcN(NoEt)_2的标记方法及其生物分布[J].核技术,1999(05):268-270. DOI：

ZHANG Junbo, WANG Xuebin. An improved labelling method on ^99mTcN（NOEt）₂ and its biodistribution[J]. Nuclear techniques, 1999, (5): 268-270. DOI：

摘要

为获得具有再分布特性的新型中性心肌灌注显像剂，采用了以ＳｎＣｌ２·２Ｈ２Ｏ为还原剂，ＳＤＨ为Ｎ３－离子提供体，在室温下制备了［９９ｍＴｃＮ］２＋ｉｎｔ中间体，然后与ＮＯＥｔ发生配体交换反应得到标记率＞９０％的９９ｍＴｃＮ（ＮＯＥｔ）２配合物。小鼠体内生物分布实验表明９９ｍＴｃＮ（ＮＯＥｔ）２具有较高的心肌摄取，在注射后５ｍｉｎ时心／血、心／肝、心／肺比值分别为１０．４８、２．０７、０．７４，脑摄取量为４．４３％ＩＤ·ｇ－１，脑／血比值为１．１２。

Abstract

mTcN(NOEt)2 is prepared through a two step ligand-exchange reaction by using SnCl2 as reduction agent and SDH (succinyl dihydrazide) as a donor of nitride nitrogen atom (N3-) at room temperature. The labelling procedure is more convenient for clinical use. The radiochemical purity (RCP) of the product is over 90% by TLC. The biodistribution results in mice indicate that 99mTcN(NOEt)2 has high myocardial uptake. For 5 min post injection the heart-to-blood

heart-to-liver and heart-to-lung ratios are 10.48

2.07 and 0.74

respectively. The uptake of brain is also good. For 5min post injection the brain uptake is 4.43%ID·g-1 and the brain-to-blood ratio is 1.12. Based on these results 99mTcN(NOEt)2 exhibits prommising properties for further studies.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

The new bone-imaging agent: Preparation and biodistribution of ⁹⁹Tc^m-ZL

Study of brain perfusion imaging agent￣（99m）-MRP20

Related Author

WANG Hongyong1

2 LUO Shineng1

2 XIE Minhao1 LIU Xiaoya2 FENG Yingying1 CHEN Zhiming1 YE Wanzhong1 1

刘晓亚

冯瑛瑛

陈志明

叶万忠

方平

Related Institution

Jiangsu Institute of Nuclear Medicine, Wuxi 214063, China) 2

江南大学化学与材料工程学院

State Key Laboratory of Nuclear Medicine, Jiangsu Institute of Nuclear Medicine

AI问答

Address：2019 Jialuo Road, Jiading, Shanghai, China Postal code：201800
Tel：021-39194977 Email：LHB@sinap.ac.cn
Technical support is provided by Beijing Founder electronics co., LTD 沪ICP备05005479号-1 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.
Total Visits：880886 Visits Today：413

⁰

An improved labelling method on 99mTcN（NOEt）2 and its biodistribution

DOI：

摘要

Abstract

关键词

Keywords

references

An improved labelling method on ^99mTcN（NOEt）₂ and its biodistribution