Evaluation and optimization of a DMSA kit for instant preparation of <sup>99m</sup>Tc（V）－DMSA

YAN Xuexian; LI Shaolin

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Evaluation and optimization of a DMSA kit for instant preparation of ^99mTc（V）－DMSA

更新时间：2021-03-12

- Evaluation and optimization of a DMSA kit for instant preparation of ^99mTc（V）－DMSA
- NUCLEAR TECHNIQUES Issue 5, (1999)
- 作者机构：
  
  重庆医科大学,重庆,400046
- 作者简介：
- 基金信息：
- DOI：
  CLC： R944
- Published：01 May 1999
- 稿件说明：
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[1]颜学先,李少林.五价锝标记DMSA药盒制备方法的评价与优化[J].核技术,1999(05):259-262.

YAN Xuexian, LI Shaolin. Evaluation and optimization of a DMSA kit for instant preparation of ^99mTc（V）－DMSA[J]. Nuclear techniques, 1999, (5): 259-262.
[1]颜学先,李少林.五价锝标记DMSA药盒制备方法的评价与优化[J].核技术,1999(05):259-262. DOI：

YAN Xuexian, LI Shaolin. Evaluation and optimization of a DMSA kit for instant preparation of ^99mTc（V）－DMSA[J]. Nuclear techniques, 1999, (5): 259-262. DOI：

摘要

采用多个条件和流程进行冻干药盒的制备和９９ｍＴＣ的标记，对得到的标记品进行理化检测和荷瘤小鼠体内生物分布试验，筛选出最佳的药盒配制和标记方法。制得的冻干药盒每瓶含ＤＭＳＡ０．５５ｍｇ，ＳｎＣｌ２０．１０ｍｇ，可用１８．５－７４０ＭＢｑ９９ｍＴｃＯ４洗脱液一步法标记，９９ｍＴｃ（Ｖ）－ＤＭＳＡ放化纯度≥９５％，带瘤小鼠组织分布瘤／肝比值为２．５，瘤／血比值为２．２。药盒室温放置４个月后性能稳定，符合临床使用要求。

Abstract

The methods to prepare instant kit of 99mTc(V)-DMSA were evaluated and optimized. Various conditions and procedures were taken to prepare and label the kit. The physico-chemical properties and biodistribution of the labelling compound were tested in order to select the optimal condition. Each kit contains 0.55mg DMSA and 0.1mg SnCl2. An aliquot of 1.0-10mL 99mTcO4 was mixed with the kit for labelling

and a radiochemical purity of ≥95% was then reached. The biodistribution ratios of tumor/liver and tumor/blood are 2.5 and 2.2 respectively in tumor bearing mice.

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Evaluation and optimization of a DMSA kit for instant preparation of 99mTc（V）－DMSA

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摘要

Abstract

关键词

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references

Evaluation and optimization of a DMSA kit for instant preparation of ^99mTc（V）－DMSA