In this study

the results of 99mTc-tetrofosmin SPECT and CT were directly compared with surgical findings for evaluating the lung and mediastinal lymph node lesions in 32 patients with lung masses

among them 16 squamous cell carcinoma

8 adenocarcinoma

4 small cell carcinoma

2 metastatic lung lesions and 2 tuberculoses. For lung lesions

99mTc-tetrofosmin SPECT showed higher sensitivity (93%

28/30)

but with two false positive TB lesions. Besides in 5 patients with tumor central necrosis

99mTo-tetrofosmin SPECT showed central activity defect comfirmed by operation. For mediastinal lymph node lesions

99mTc-tetrofosmin SPECT has better sensitivity and specificity (88% and 87%) than CT scan (59% and 67%). Thereby

99mTc-tetrofosmin SPECT was an accurate and effective method in evaluating the lung cancers and mediastinal lymph node metastases especially for the latter ones.