最新刊期
      卷 0 ， 期 0 ， 2020
      • Issue 11, (1995)
        摘要：mTc-DTPA renography was performed in 64 cases of type Ⅱ diabetes mellitus and 20 control subjects. The value of GFR in the controls was 113±11.7ml/min. The value of GFR in 15 of 43 patients with negative proteinuria was more than 140ml/min, but GFR in the 21 diabetes with positive proteinuria was 76 ± 32.9ml/min.These data indicated that 99mTc-DTPA renography is a accurate and sensitive method for evaluation of hyperfiltration in early diabetes mellitus.  
        关键词：Radionuclide imaging;Diabetic nephropathy;DTPA   
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        发布时间：2021-04-09
      • Issue 11, (1995)
        摘要：The cholinergic M1 muscarinic receptors in brains of aged rats and the regulation effects of ZM （Anemarrhena asphodeloicles Bunge） and its sapogenine ZMS were studied with autoradiography of 3H-pirenzepine. The mean grain densities in different brain areas were estimated by a computerized image-analysis system. The specific bindings of aged rats were decreased by 15% in cerebral cortex and striatum and by nearly 10% in hippocampus. Parallel experiments showed that chronic daily oral administration of ZM or its sapogenine ZMS to aged rats can attenuate the decrease of M1 receptor densities of the above three areas and keep them nearly normal for a long time.  
        关键词：Brain M1 receptors;Autoradiography;Aged rats;3H-pirenzipine   
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        发布时间：2021-04-09
      • Issue 11, (1995)
        摘要：himeric McAb ccM4 was labelled with 99mTc by direct method. The antibody was reduced by molar excess 2-mercaptoethanol （2-ME; Ab, 1000:1）. The reduced ccM4 chimeric McAb was mixed with 99mTc reduced by SnCl2 and 99mTc labelling efficiency was 98%. The immunoreactivity was not change after labelling. The biodistribution of 99mTc-ccM4 was performed in nude mice and patients with stomach carcinoma. There was significantly more radioactivity in tumor than in the rest of the body in nude mice. Radioimmunoimaging of ccM4 in 10 patients of gastric cancer was also presented.  
          
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        发布时间：2021-04-09
      • Issue 11, (1995)
        摘要：cases of liver cancer （4 primary and 5 metatic） using 90Y-glass traped microspere injected into the unresected liver masses guided by realtime liver echography were reported. Two months later B ultrasound indicated there was a density change of the tumor mass with various magnitude, among them low density area almost disappeared in one case. The gistologic studies showed some tumor cells becaxne nectotic and leaves a hollow space. No patients complained discomfort or pain during and after treatment. It is not harmful to surrounding tissues. therefore this method may be an effective therapy modality to treat the inoperable liver cancer without obvious side effects.  
        关键词：Radionuclide imaging;B ultrasound scan;￣90Y-glass microsphere;Intervention ultrasound   
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        发布时间：2021-04-09
      • Issue 11, (1995)
        摘要：The kinetics of P-125IPPA in vivo rats after dobutamine-induced stress was studied in order to develop a method for clinical myocardial imaging. P-125IPPA was labelled by solid-phase iodine isotope exchange method.Both dobutamine-induced rats（DIR） and non-induced rats（NIR） （24 rats in each group）were killed in successive intervals at1,2,3,4,5,7,10 and 25 min after injection of P-125IPPA.Radioactivity of heart, blood,lung,liver and kidney in each phase was calculated as percentage of administered dose per g tissue（%ID/g） and glucose,kerone-bodies and triglycerides serum levels were also measured. Cardiac uptake of p-125IPPA in DIR was 1.5 times （P<0.05） higher than NIR.During 1-7min interval, heart-to-blood ratio was 1.8 times（P<0.01） greater than NIR.β-oxidation seem to be accelerated and triglycerides serum levels were lower （P<0.01） at 1-2min postinjection in DIR.The elimination of heart activity was significantly slower in DIR than are with T1/2 of 5.2min and 3.4min respectively. Except the early uptake in liver lowered,the activity in other tissues had not been changed after dobutamine-induced stress, so the ratio of heart-to-iting and heart-to-liver was increased 1.4 and 1.7 times （P<0.05） respectively in early 7 min.  
        关键词：Free fatty acids;Oxidative metabolism;P-（125）￣IPPA;Dobutamine   
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        发布时间：2021-04-09
      • Issue 11, (1995)
        摘要：When normal volunteers and hepatocirrhotic patients were given orally a single small dose of MPA （p-methoxyphenyl acetamide） and their plasma MPA time courses were determined by stable isotope dilution analysis, it was found that several kinetic parameters of MPA were significantly different among normal adults, compensated cirrhotic patients, and decompensated cirrhotic patients. A simplified method was established which requires only a single 2ml blood sample drawn 30 min after an oral dose of 1.5mg·kg-1 MPA. Application of this method in 30 normal subjects, 12compensated and 39 decompensated cirrhotic patients revealed that it can sensitively distinguish the hepatic functional state of the three groups. In addition, it can also reflect the improvement of liver function after nutritional therapy.  
        关键词：p-methoxyphenyl acetamide;Isotope dilution analysis;Hepatic cirrhosis;Assessment of hepatic function;Methacetin   
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        发布时间：2021-04-09
      • Yu Zhichang
        Issue 11, (1995)
        摘要：Gastric emptying studies were performed on 10 healthy volunteers and 20duodenal ulcer （DU）,14 gastric ulcer（GU）and 4 non-ulcer dyspepsia （NUD） patients utilizing a radionuclide technique to assess emptying rate of solid meal （99mTc-phytate collide labelled chicken liver）.For normal subjects the average gastric half-emptying time was 53.8 ± 13.2min. 6 DU patients （6/20） has significantly faster gastric half-emptying time （23.3±3.6min） and other DU patients（7/20） had slower gastric half-emptying time （>90min） than normals.In addition,2 GU patients had fast （<30min） and 4 GU patients had slow gastric half-emptying time （>90min）.These results suggested that gastric emptying time may be useful for monitoring the thrapeutic effect.  
        关键词：m)￣Tc;Sodium phytate;Gastric emptying time   
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        发布时间：2021-04-09
      • Issue 11, (1995)
        摘要：A mini-paper chromatography （MPC） system has been developed to analyze the radiochemical purity of 99mTc-HMPAO involving a 1:1 chloroform/tetrahydrofuran developing solvent. The MPC procedure is compared with the method of two thin layer chromatographic system and one paper chromatographic system （TLC/PC）. The results of the paired t-tests show that radiochemical purities measured by MPC and TLC/PC do not difference significantly （P>0.05）. For radiochemical purity values ranging from 74.2%- 96.4% （n=30）, the MPC and TLC/PC methods correlated closely （r= 0.97） with a regression equation of MPC （%） = 1.006 TLC/PC-0.323.  
        关键词：m)Tc-HMPAO;Radiochemical purity;Mini-paper chromatography   
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        发布时间：2021-04-09
      • Issue 11, (1995)
        摘要：Samarium-153 - ethylendiamine tetramethylene phosphonic acid （EDTMP）, a bone-seeking radiopharmaceutical, was given to treat patients with disseminated bone metastases. A total of fifty patients, 26 male and 24 female, 44 metastastic and 6 primary bone tumor were treated with a single dose of 1480MBq. Some of them had 153Sm-EDTMP whole-body bone scans 48 hours after 153Sm-EDTMP, and their lesion-to normal ratios of bone were calculated. Overall allevaition of pain with 153Sm-EDTMP was 76% （38150） and 24% of the patients were completely relief from pain. Pain relief sustained from 4 to 8 weeks in 60% of patients.It was suggested that this new therapeutic agent may have a potential benefit for the diagnosis and management of disseminated metastatic bone carciomas.  
        关键词：?153)Sm-EDTMP;Tumorous bone pain;Radiotherapy   
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        发布时间：2021-04-09
      • Issue 11, (1995)
        摘要：With the circulating endothelial cell（CEC）as an indicator of vessel endothelial cell（VEC）injury,and plasma endothelin（ET）and prostaglandin F1a（PGI2）reflecting the functional change of the VEC,a comparative study between 85 patients with coronary heart disease and 30 normal health,and also a dynamic observation of 50 patients with unstable angina pectoris and 20 patients with acute myocardial infarction（AMI）were reported. The result showed that in patients with coronary heart disease,peripheral blood circulating CEC and ET level was increased（P<0.001）,while the PGI2 decreased （P<0.01）, all these were more significant in patients with unstable angina pectoris and myocardial infarction, and its magnitudecorrelated closely with the seventy of the disease. All these showed that the VEC injury and the imbalance of its endothelial relaxing and contracting factors have played an important role in the pathogenesis of coronary heart disease.  
        关键词：Coronary heart disease;Circulation endothelial cell;Endothelin;PGI2   
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        发布时间：2021-04-09
      • Issue 11, (1995)
        摘要：A solid phase immunoradiometric assay using three CEA monoclonal antibodies was established. Two McAbs against two different determinants of CEA were covalently bonded to polystyrene tubes, the other was radioiodinated by the Iodogen method. The method has the advantage of high sensitivity, specificity, reproducibility and the procedure is rather sample. There is a good correlation between this assay and conventional RIA.  
        关键词：CEA;Monoclonal antibody;Immunoradiometric assay   
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        发布时间：2021-04-09
      • Issue 11, (1995)
        摘要：发挥核技术的优势，为受体研究作出更多贡献夏宗勤（上海第二医科大学上海２０００２５）近年来，一些探讨生物医学发展战略的重要著作［１－４］都把受体放在很重要的位置，这主要是因为：（１）神经递质、激素、细胞生长因子、免疫调节因子以及相关的药物等，都首先要通...  
          
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        发布时间：2021-04-09
      • Issue 11, (1995)
        摘要：Eleven （RS）-amino substitated benzamide compounds not yet reported in literature were synthesised. Radioligand competitive binding assay using 3H-sulpiride as the radioligand proved that these compounds were dopamine D2receptor antagonists. Determination of IC50 showed that the affinity for D2 receptor of the amino substituted and halogen-containing benzamide compounds were about ten times higher than that of sulpiride.  
        关键词：Benzamide;Dopamine receptor;Radioligand binding assay   
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        发布时间：2021-04-09
      • Issue 11, (1995)
        摘要：Nude mice bearing transplanted human prostate cancer cell line PC-3M were treated with male sex hormone. Results demonstrated that low dose of testosterone propionate （TP）（50mg/kg wt.）stimulated the tumor growth,and the androgen receptor（AR）levels and protein kinase C （PKC） activity were elevated in the tumor tissue.On the contrary higher dose of TP（400mg/kg wt.） inhibited the tumor growth,and the AR level and PKC activity in tumor tissue were reduced significantly.These results showed that TP has a biphasic effect on the growth of human prostate cancer PC-3M cell line. The mechanism of the biphasic effect and its relationship between AR and PKC levels are also discussed.  
        关键词：Androgen;Human prostate cancer;Androgen receptor;Protein kinase C   
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        发布时间：2021-04-09
      • Issue 11, (1995)
        摘要：With monoclonal anti-body SZ-51,activited levels of platelet granule membrane protein（GMP-140） in coronary heart disease（CHD） were assayed by RIA. The results showed that the levels of GMP-140 with CHD were higher than that of controls （P>0.001）.The levels of GMP-140 with AMI treated with urokinase for thrombolysis in 12 hours were considerably lower than that one hour before treatment.Therefore, the measurement of GMP-140 with CHD is of great clinical value in diagnosing and differentiating AMI, especially, in analysing pathogeny,in monitoring curative effect and predicting prognosis for AMI.  
        关键词：Platelet;Granule membrane;Thrombosis;Coronary heart disease;Radio-immunoassay（RIA）   
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        发布时间：2021-04-09
      • Issue 11, (1995)
        摘要：This report describes the routine method for preparing BZM and IBZM.I-IBZM was prepared by the chloramine-T method and was purified by TLC.The radiochemical purity was better than 90%.（S）-（-）-125I-IBZM can specific bound with rat striatal homogenate in vitro.  
        关键词：Neuroreceptor imaging agent;Dopamine D2 recepter;Benzamide compounds   
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        发布时间：2021-04-09
      • Cheng Muhua
        Issue 11, (1995)
        摘要：normal controls and 27 patients with ventricular pacemaker had undergone planar gated blood-pool imaging in different conditions. Result shows: （1） Pump parameters can successfully reflect theraupeutic effect of pacemaker among them EMP is the most valuable parameter for evaluating the cardiac pumping effect. （2）After implantation of the ventricular pacemaker, the LVEF didn’t increase, but the CO and EMP was significantly increased.（3）Compared with right ventricular demand pacemaker, the rate-responsive ventricular pacemaker give better hemodynamic benifit at exercise condition.（4）Through restrained cardiac pacemaker the functional change was analyzed on or off pace,and monitoring the cardiac function itself after the pacemaker was implanted.  
        关键词：Radionuclide gated blood-pool imaging;Cardiac function pump parameter;Ventricular pacemaker;Pacing effect   
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        发布时间：2021-04-09
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