Clinical investigation of metastatic bony pain treated by ￣（153）Sm-EDTMP

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Clinical investigation of metastatic bony pain treated by ￣（153）Sm-EDTMP

更新时间：2021-04-09

- Clinical investigation of metastatic bony pain treated by ￣（153）Sm-EDTMP
- NUCLEAR TECHNIQUES Issue 11, (1995)
- 作者机构：
  
  上海医科大学附属华山医院
- 作者简介：
- 基金信息：
- DOI：
  CLC： R730.5
- Published：01 November 1995
- 稿件说明：
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[1]蒯大禹,李明,管一晖,程玮.~（153）Sm－EDTMP治疗50例肿瘤性骨痛临床观察[J].核技术,1995(11):697-698.

Clinical investigation of metastatic bony pain treated by ￣（153）Sm-EDTMP[J]. Nuclear techniques, 1995, (11).
[1]蒯大禹,李明,管一晖,程玮.~（153）Sm－EDTMP治疗50例肿瘤性骨痛临床观察[J].核技术,1995(11):697-698. DOI：

Clinical investigation of metastatic bony pain treated by ￣（153）Sm-EDTMP[J]. Nuclear techniques, 1995, (11). DOI：

摘要

５０例不同癌症患者用１５３Ｓｍ－ＥＤＴＭＰ治疗后７６％患者的骨痛有不程度的减轻，骨痛消失率达２０％，骨痛缓解时限１—２个月者为６０％。１０例患者９９ｍＴｃ－ＭＤＰ骨显像患／健侧值与１５３Ｓｍ－ＥＤＴＭＰ相隔１个月两个疗程骨显像患／健侧值自身对照（Ｐ＞０．０５）．表明１５３Ｓｍ－ＥＤＴＭＰ对缓解骨痛、控制临床症状，提高癌症患者的生活质量，作为一种姑息性治疗手段具有明显的临床推广和应用价值．

Abstract

Samarium-153 - ethylendiamine tetramethylene phosphonic acid （EDTMP）

a bone-seeking radiopharmaceutical

was given to treat patients with disseminated bone metastases. A total of fifty patients

26 male and 24 female

44 metastastic and 6 primary bone tumor were treated with a single dose of 1480MBq. Some of them had 153Sm-EDTMP whole-body bone scans 48 hours after 153Sm-EDTMP

and their lesion-to normal ratios of bone were calculated. Overall allevaition of pain with 153Sm-EDTMP was 76% （38150） and 24% of the patients were completely relief from pain. Pain relief sustained from 4 to 8 weeks in 60% of patients.It was suggested that this new therapeutic agent may have a potential benefit for the diagnosis and management of disseminated metastatic bone carciomas.

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