Influences of androgen on the growth of human prostate cancer PC-3M model in nude mice and the changes of the androgen receptor levels and protein kinase C activity

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Influences of androgen on the growth of human prostate cancer PC-3M model in nude mice and the changes of the androgen receptor levels and protein kinase C activity

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- Influences of androgen on the growth of human prostate cancer PC-3M model in nude mice and the changes of the androgen receptor levels and protein kinase C activity
- NUCLEAR TECHNIQUES Issue 11, (1995)
- 作者机构：
  
  1. 中山医科大学
  2. 广州暨南大学医学院
  3. 广州医学院附属二院
  4. 中山医科大学广州暨南大学医学院广州医学院附属二院
- 作者简介：
- 基金信息：
- DOI：
  CLC： Q579.11
- Published：01 November 1995
- 稿件说明：
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[1]桂治宁,曾熙兰,陈健,武兆忠.雄激素对人前列腺癌（PC—3M）裸鼠模型生长的影响及其雄激素受体和蛋白激酶C变化特性[J].核技术,1995(11):655-658.

Influences of androgen on the growth of human prostate cancer PC-3M model in nude mice and the changes of the androgen receptor levels and protein kinase C activity[J]. Nuclear techniques, 1995, (11).
[1]桂治宁,曾熙兰,陈健,武兆忠.雄激素对人前列腺癌（PC—3M）裸鼠模型生长的影响及其雄激素受体和蛋白激酶C变化特性[J].核技术,1995(11):655-658. DOI：

Influences of androgen on the growth of human prostate cancer PC-3M model in nude mice and the changes of the androgen receptor levels and protein kinase C activity[J]. Nuclear techniques, 1995, (11). DOI：

摘要

采用雄性激素治疗移植人前列腺癌细胞株（ＰＣ—３Ｍ）所复制的裸鼠模型．结果表明，低剂量丙酸睾丸素（５０ｍｇ／ｋｇ体重）明显促进肿瘤生长，同时肿瘤组织中雄激素受体（ＡＲ）水平及蛋白激酶Ｃ（ＰＫＣ）活性均明显增高；而高剂量丙酸睾丸素（４００ｍｇ／ｋｇ体重）则明显抑制肿瘤生长，且肿瘤组织中ＡＲ水平及ＰＫＣ活性明显降低．显示雄激素对人前列腺癌（ＰＣ－３Ｍ）细胞株具有双相效应．讨论了这种双相效应与ＡＲ和ＰＫＣ变化的关系．

Abstract

Nude mice bearing transplanted human prostate cancer cell line PC-3M were treated with male sex hormone. Results demonstrated that low dose of testosterone propionate （TP）（50mg/kg wt.）stimulated the tumor growth

and the androgen receptor（AR）levels and protein kinase C （PKC） activity were elevated in the tumor tissue.On the contrary higher dose of TP（400mg/kg wt.） inhibited the tumor growth

and the AR level and PKC activity in tumor tissue were reduced significantly.These results showed that TP has a biphasic effect on the growth of human prostate cancer PC-3M cell line. The mechanism of the biphasic effect and its relationship between AR and PKC levels are also discussed.

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