A study in platelet GMP-140 for coronary heart disease by RIA

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A study in platelet GMP-140 for coronary heart disease by RIA

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- A study in platelet GMP-140 for coronary heart disease by RIA
- NUCLEAR TECHNIQUES Issue 11, (1995)
- 作者机构：
  
  1. 南京市医学放射免疫检测中心
  2. 南京市第一医院
  3. 南京市医学放射免疫检测中心南京市第一医院
- 作者简介：
- 基金信息：
- DOI：
  CLC： R541.4
- Published：01 November 1995
- 稿件说明：
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[1]杜同信,王自正,时宏珍,陆雪龙,刘家琴,龚和禾,张正毅.冠心病患者血小板GMP—140RIA的研究[J].核技术,1995(11):702-704.

A study in platelet GMP-140 for coronary heart disease by RIA[J]. Nuclear techniques, 1995, (11).
[1]杜同信,王自正,时宏珍,陆雪龙,刘家琴,龚和禾,张正毅.冠心病患者血小板GMP—140RIA的研究[J].核技术,1995(11):702-704. DOI：

A study in platelet GMP-140 for coronary heart disease by RIA[J]. Nuclear techniques, 1995, (11). DOI：

摘要

应用单克隆抗体ＳＺ－５１，通过放射免疫分析测定了９４例冠心病患者血小板ａ颗粒膜蛋白（ＧＭＰ－１４０）的活化分子数．实验结果表明；冠心病组患者血小板ＧＭＰ－１４０分子数比正常对照组明显增高（Ｐ＜０．００１）；急性心肌梗塞（ＡＭＩ）患者用尿激酶溶栓治疗后１２ｈ的血小板ＧＭＰ－１４０的活化分子数比治疗前１ｈ明显降低（Ｐ＜０．００１）．说明冠心病患者血小板ＧＭＰ－１４０的检测，对其诊断及鉴别诊断，尤其对ＡＭＩ的病因分析、治疗及预后判断都具有重要价值．

Abstract

With monoclonal anti-body SZ-51

activited levels of platelet granule membrane protein（GMP-140） in coronary heart disease（CHD） were assayed by RIA. The results showed that the levels of GMP-140 with CHD were higher than that of controls （P>0.001）.The levels of GMP-140 with AMI treated with urokinase for thrombolysis in 12 hours were considerably lower than that one hour before treatment.Therefore

the measurement of GMP-140 with CHD is of great clinical value in diagnosing and differentiating AMI

especially

in analysing pathogeny

in monitoring curative effect and predicting prognosis for AMI.

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