The kinetics of P-125IPPA in vivo rats after dobutamine-induced stress was studied in order to develop a method for clinical myocardial imaging. P-125IPPA was labelled by solid-phase iodine isotope exchange method.Both dobutamine-induced rats（DIR） and non-induced rats（NIR） （24 rats in each group）were killed in successive intervals at1

2

3

4

5

7

10 and 25 min after injection of P-125IPPA.Radioactivity of heart

blood

lung

liver and kidney in each phase was calculated as percentage of administered dose per g tissue（%ID/g） and glucose

kerone-bodies and triglycerides serum levels were also measured. Cardiac uptake of p-125IPPA in DIR was 1.5 times （P<0.05） higher than NIR.During 1-7min interval

heart-to-blood ratio was 1.8 times（P<0.01） greater than NIR.β-oxidation seem to be accelerated and triglycerides serum levels were lower （P<0.01） at 1-2min postinjection in DIR.The elimination of heart activity was significantly slower in DIR than are with T1/2 of 5.2min and 3.4min respectively. Except the early uptake in liver lowered

the activity in other tissues had not been changed after dobutamine-induced stress

so the ratio of heart-to-iting and heart-to-liver was increased 1.4 and 1.7 times （P<0.05） respectively in early 7 min.