A plasma MPA clearance test for the assessment of hepatic function

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A plasma MPA clearance test for the assessment of hepatic function

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- A plasma MPA clearance test for the assessment of hepatic function
- NUCLEAR TECHNIQUES Issue 11, (1995)
- 作者机构：
  
  上海第二医科大学附属瑞金医院
- 作者简介：
- 基金信息：
- DOI：
  CLC： R962
- Published：01 November 1995
- 稿件说明：
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[1]金小华,唐振铎,施菊,戴腾昌,夏宗勤.对甲氧基苯乙酰胺血浆清除试验用于肝功能测定[J].核技术,1995(11):682-686.

A plasma MPA clearance test for the assessment of hepatic function[J]. Nuclear techniques, 1995, (11).
[1]金小华,唐振铎,施菊,戴腾昌,夏宗勤.对甲氧基苯乙酰胺血浆清除试验用于肝功能测定[J].核技术,1995(11):682-686. DOI：

A plasma MPA clearance test for the assessment of hepatic function[J]. Nuclear techniques, 1995, (11). DOI：

摘要

人一次口服小量对甲氧基苯乙酰胺（简称ＭＰＡ）后，用稳定核素稀释法测定血药浓度的时相曲线，并算出多项动力学参数．结果显示，正常人与肝硬化病人间有高度显著差异。３０例正常人、１２例代偿期和３９例失代偿期肝硬化病人一次口服１．５ｍｇ·ｋｇ－１ＭＰＡ后３０ｍｉｎ，取一次静脉血，测定血浆ＭＰＡ浓度，不仅能敏感地区分正常人与肝硬化代偿期、肝硬化代偿期与失代偿期之间的差异，而且能反映肝硬化病人营养治疗后肝功能改善的情况．该方法临床上简便易行，是一种能反映肝细胞损害程度的较好的肝功能试验方法．

Abstract

When normal volunteers and hepatocirrhotic patients were given orally a single small dose of MPA （p-methoxyphenyl acetamide） and their plasma MPA time courses were determined by stable isotope dilution analysis

it was found that several kinetic parameters of MPA were significantly different among normal adults

compensated cirrhotic patients

and decompensated cirrhotic patients. A simplified method was established which requires only a single 2ml blood sample drawn 30 min after an oral dose of 1.5mg·kg-1 MPA. Application of this method in 30 normal subjects

12compensated and 39 decompensated cirrhotic patients revealed that it can sensitively distinguish the hepatic functional state of the three groups. In addition

it can also reflect the improvement of liver function after nutritional therapy.

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