最新刊期
      卷 0 ， 期 0 ， 2020
      • Issue 5, (1998)
        摘要：125I-IBZM autoradiographic analysis, HPLC-ECD were used to study therelationship between D2 receptors and the content of DA, HVA, DOPAC in striatumof hemi-parkinsonism model rats before and after Madopar treatment. After Madopartreatment, the striatum/cerebellum 125I-IBZM uptake ratio of lesioned side was 7.23±0.67, showed 17.22± 3.94% increasing as compared to the contralateral side, theincreasing were significantly declined compared with the pretreatment group andcontrol group （P<0.01）. The DA, HVA, DOPAC levels in lesioned side striatum ofMadopar group were increased compared with the other two groups （P<0.05）. All ofthe above verified that Madopar treatment can elevate DA levels of lesioned striatumin hemi-parkinsonism model rats, and thus prevent and reverse the up-regulation ofD2 receptors.  
        关键词：Parkinsonism;Dopamine D2 receptor;IBZM;Dopamine   
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        发布时间：2021-04-09
      • Issue 5, (1998)
        摘要：This study was to evaluate myocardial cell and mitochondrial viability with99mTc-MIBI. In vivo studY, 185Mbq 99mTc-MIBI was injected intravnously intorabbits 2-5 min after reperfusion preceded 20 min （Group A） or 3h （Group B） of LADocclusion. In Group B, relative sestamibi activity of ischemic myocardiam andmyocardial ATP contents was significantly lower than Group A; and a significantlypositive correlation between SDH and subcellular sestamibi distribution （r=0.88, P<0.001） was found. In vitro study, the capacity of mitochondria preparation tosequester sestamibi was examined after 20 min as percent of total 99mTc activity. Itwas 9.70 ± 2.59%, 10.05 ± 2.00% and only 3.89 ± 1.48% in nonischemic, reversible andirreversble damaged myocardium respectively. After addition of succinate, increasedto 50.27± 12.04%, 52.70± 10.97% and 6.08± 3.26%, respectively was observed.Myocardial 99mTc-MIBI mainly localized within mitochondria. Myocardial kinetics of99mTc sestamibi was significantly affected by myocardial metabolism and viability.  
        关键词：99mTc-MIBI;Mitochondria;Kinetics;Reperfusion;Myocardial viability   
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        发布时间：2021-04-09
      • Issue 5, (1998)
        摘要：20 patients with recent acute myocardial infarction （AMI） were divided intoperfosion group （12 cases） and non-perfusion group （8 cases）. All were performed by99mTc-MIBI SPECT imaging before thrombolytic therapy. The scintigraphy wasrepeated 5- 7 days later. SPECT was evaluated using an uptake score. The datashowed that the patency rate of infarct-related coronare atery was 66.7% and 50%respectively in AMI treated by urokinase within 6 and 6- 12 hours after onset.SPECT defect score was similar before thrombolysis in perfusion group andnon-perfusion group. SPECT defect score was significantly lower after thrombolysiscompared with before thrombolysis in reperfusion group （P< 0.05）. The percentdecrease of the uptake defects was 70.2 ± 10.8%. But SPECT defect score was similarbetween the 2 images in non-reperfusion group （P> 0.05）. It was concluded thatthrombolytic therapy can save dying myocardium and decrease the infarct size andalso improve heart function. Thereby, SPECT 99mTc-MIBI was a good method forevaluation of the infarct size and thrombolytic effects.  
        关键词：Acute myocardial infarction;Thrombolytic therapy;99mTc-MIBI SPECT   
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        发布时间：2021-04-09
      • Issue 5, (1998)
        摘要：This study compares the diagnostic value of 18F-FDG PET and 99mTc-MIBISPECT imaging in the diagnosis of recurrence and malignancy of glioma. 28 patientswith glioma post treatment were performed by MRI or/and CT and 18F-FDG PETimagmg, and 14 of them were also performed by 99mTc-MIBI SPECT. On PET scans,10 patients were hypometabolic, 4 patients were central non-metabolic withperipheral rm FDG uptake, 14 patients were hypermetabolic. Out of 8 patients withastrocytoma Ⅰ - Ⅱ grade confirmed by operation, 5 ones showed hypermetabolic,indicating malignant degeneration of low-grade glioma. The sensitivity and accuracyof 18F-FDG PET and 99mTc-MIBI SPECT in the diagnosis of recurrence andmalignant degeneration of glioma were 93.3%, 94.1% and 91.7%, 85.7% respectively.FDG PET imaging is the most accurate method in the detection of recurrence andmalignant degeneration of low-grade glioma, compared with MRI enhancement and99mTc-MIBI SPECT. The extent of lesion site detected by MIBI scans is usuallybigger than FDG PET imaging.  
        关键词：Glioma;Malignant degeneration;Recurrence;Radionuclide imaging;Nitriles;Deoxyglucose   
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        发布时间：2021-04-09
      • Issue 5, (1998)
        摘要：Ambulatory radionuclide manitoring of left ventricular function was performedwith the VEST in 35 patients with coronary artery disease and 5 normal subjects. Atransient decrease in left ventricular ejection fraction （5%） lasting over 1 min wasobserved in 24 of the 35 patients with CAD during daily activities, only 4 episodeswere accompanied with chest pain and 20 （83%） were asymptomatic. VEST maycontinuously monitor the change of both left ventricular function and the ECGduring the activities of daily life. It was an accurate and sensitive parameter for thediagnosis of silence myocardial ischemia.  
        关键词：Coronary artery disease;Ambulatory radionuclide monitoring;Left ventricular function   
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        发布时间：2021-04-09
      • Issue 5, (1998)
        摘要：Avascular necrosis of femoral head （AVN） was induced unilaterally in 10 dogs byfrozen. Dynamic bone Anaging was performed before, and 1, 3, 5, 7, 12, 19 and 33 daysafter operation. The perfusion index of femoral head （FPI） was calculated by thegraphical approach of time-activity curves and quantitation of data. Based onhistological examination, pathological lesions on 10 dogs could be classified into fourstages: edema, hemorrhage, liquidation, and granulation formation with focal fibrosis,etc. Decreased FPI index was found in all lesions of 10 dogs by dynamic boneimaging. Until 19 days after operation, the uptake was reduced compared to thenormal side, whereas after 33 days, its uptake was increased. Perfusion index wasconsidered to reveal the blood flow condition in femoral head. It can be used todetect the early stage of AVN and to understand the effects of various modes oftherapy.  
        关键词：Avascular necrosis;Dynamic bone imaging;Blood flow perfusion   
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        发布时间：2021-04-09
      • Issue 5, (1998)
        摘要：At present, the apoptosis in Molt-4 cell（a humaan acute lymphoblastic leukemiacell line） and Ana-1 cell （a macrophage cell line） were studied after internalirradiation with enriched 235U. The cumulative radiation absorption dose of 235U incultural cells through different periods were estimated, The morphological changes,which observed by electron microscope, indicated that Molt-4 and Ana-1 immunecells after incubation with 235U, displayed nuclear fragmentation, margination ofcondensed chromatin, as well as the membrane-bounded apoptotic bodies formation.The agarose gel electrophoretic observations showed the DNA ladder paternformation in Molt-4 cell as well as in Ana-1 cell. The experimental results showedthat apoptosis induced by 235U in immune cells, were dependent on the 235U-treatedtime and cumulative radiation absorption dose.  
        关键词：Enriched 235U;Molt-4 cell;Ana-1 cell;Electron microscopy;Gel electrophoresis;Apoptosis   
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        发布时间：2021-04-09
      • Issue 5, (1998)
        摘要：The purpose of this paper was to investigate in vivo behavior of biodistributionand elimination of myocardial viability imaging agent 125I-IPPA. Myocardial uptakeof 125I-IPPA in rats showed a peak of 4.4% of injected dose per gram at 1 min. Thehalf elimination time of myocardium was 3.8 min. The maximal uptake of thyroid wasonly 0.005%ID/organ at 120 min. The initial half time of 2.7 min in rabbits wasobtained from the elimination curve of radioactivity in blood. In vitro binding test for125I-IPPA to HSA showed rather constant level of activation during the two hours.The second peak of extraction was observed in major organs of rat, in rabbits’elimination of radioactivity, in vivo binding test for 125I-IPPA to HSA.  
        关键词：125I-IPPA;Fatty acid;Animal experiment   
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        发布时间：2021-04-09
      • Issue 5, (1998)
        摘要：The animal experiments of a novel somatostatin receptor-positive tumorsimaging agent, 111In- DTPA - D - Phe1 - octreotide, has been described. Biologicalproperties were evaluated by dynamic and static γ images of somatostatinreceptor-positive tumors in nude mice bearing pancreatic carcinoma. Theradiocomponent of 111In-DTPA, which came from 111In-DTPA-D-Phe1-octreotidedecomposition, showed 50% of radioactivity in blood and 40% in urine at 3hpostinjection. Rapid blood and urine clearance, and high T/B ratio （7.92 up to 24hpostinjection） were observed. The images of somatostatin receptor-positive tumorscould be obtained during 0.5- 24h after administration but the best one would be at24h.  
        关键词：111In-DTPA-D-Phe1-octreotide;Somatostatin receptor-positive tumors;Nude mouse bearing pancreatic carcinoma;Imaging agent   
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        发布时间：2021-04-09
      • Issue 5, (1998)
        摘要：The authors reported the reactions of glycine, alycine and glycine ethyl esterwith pyridoxal chloride to form the base and the compound chelated with 99mTc in thepresence of SnCl2· 2H2O. The metabolism of this compound in vivo was alsoobserved. The influencing factors were studied and the best labelling procedures wereobtained. The animal experiment on 99mTc-SB-Gly indicated that this agent could berapidly excreted through the kidney into the urine after intravenous injection, withan excretory rate of 79.68± 6.66ID% in 30min via urine, a little bit lower than99mTc-DTPA （82.56 ± 6.88ID%）, but having a clear renal scintigraphy. Besides, theelimination of blood was rapid and the labelling compound had enough safety. Ininhibition experiments with probencid in rats, the urine excretion rate was notaffected, suggesting that this compound passed through by glomerular filtration.  
        关键词：Renal radiopharmaceutical;99mTc   
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        发布时间：2021-04-09
      • Issue 5, (1998)
        摘要：Regional blood flow （rBF） of femur neck in 18 normal people, 8 arascular necroisof femur neck （AVNFN） patients and 7 fracture of femur neck （FFN） patients weremeasured with 133Xe washout method. The results showed that the average rBF offemtir neck in normal people, the AVNFN patients and the FFN patients are 7.22±0.53, 5.39± 1.48 and 6.74± 1.63 mL/（100g·min） respectively. The rBF of AVNFNpatients was lower than that of normal people （t = 6.028, P<0.001）; whereas the rBFof fracture patients was not statistically different from that of the normal people（t = 1.357, P>0.20）.  
        关键词：133Xe washout method;Blood flow;Osteonecrosis;Fracture   
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        发布时间：2021-04-09
      • Issue 5, (1998)
        摘要：[α -15N]-dl-tryptophan was synthesized by the use of Al-Ni alloy catalytichydrogenation from 15N-glycine via several steps. The overall yield of the finalproduct was 46.9% and the abundance of 15N was about 93%. The physicochemicalproperties of the synthetic compound obtained were the same as those of the standardtryptophan. Its structure were confirmed by the elemental analyses, MS, UV andpaper chromatography.  
        关键词：[α-15N]-dl-tryptophan;Al-Ni alloy;Synthesis   
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        发布时间：2021-04-09
      • Issue 5, (1998)
        摘要：Serum CA15-3 levels of 41 pre-operative patients with breast tumor and 113post-operative patients with breast cancer were meassured by radioimmunoassay.The sensitivity and specificity were 20%, 93.7%, and 71.2%, respectively. In 50patients with bone metastasis, the sensitivity was 78.0%. It appears that due to itslow sensitivity for early diagnosis, CA15-3 RIA has little use for screening in generalpopulation to detect primary breast cancer in early stage but is benefical fordetecting its metastasis and recurrence.  
        关键词：CA15-3;Radioimmunoassay;Breast cancer;Metastasis   
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        发布时间：2021-04-09
      • Issue 5, (1998)
        摘要：Single photon bone densitometer has been used to determine the bone mineralcontents in 1521 cases of mid and late pregnant women. The results showed that thecontents are significantly lower than the normal group（P<0.001）. Varying degrees ofbone mineral loss took place in 488 cases（32.1%） of pregnant women. Serumosteocalcin（BGP） levels in 40 cases of normal nonpregnant women and 41 cases of thebone mineral loss group of pregnant women have been measured simultaneously, Theresults showed that the contents of the bone mineral loss group of pregnant womenare obviously lower than the normal group（P<0.001）. This fact implies that thedeterminations of single photon bone densitometer and serum BGP RIA can be usedas the indices for assessing the bone mineral loss in pregnant women.  
        关键词：Mid and late pregnant women;Single photon bone densietometer;Bone mineral loss;Osteocalcin;Radioimmunoassay   
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        发布时间：2021-04-09
      • Issue 5, (1998)
        摘要：201TlCl scintigraphy in 19 cases of thyroid follicular nodules after 99mTcscintigraphy visualised a thyroid cold nodules. The results showed that 201TlCl uptakein cold nodules of 6 cases still remained deficient. 201TlCl uptake of 10 nodules wasthe same as normal throid tissue, whereas that of 3 nodules higher than normalthyroid tissue. The overall positivity was 13/19.  
        关键词：Thyroid follicular adenoma;Thyroid cold nodules;201TlCl scintigraphy   
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        发布时间：2021-04-09
      • Issue 5, (1998)
        摘要：The tissue distribution of 125I-BMIPP in Sprague-Dawley （SD） rats and theeffect of blood now on myocardial uptake of BMIPP were reported. The resultshowed myocardial uptake at 5 min after 125I-BMIPP injection was 3.86%ID/g andremained constant up to 60 min. The ratios of myocardium/blood andmyocardium/lung as well as myocardium/liver were 1.56, 2.08 and 1.62 respectively at30 min. The liver showed rapid clearance of 125I-BMIPP. In dipyridamole group,myocardial uptake of 125I-BMIPP （3.90±0.25%ID/g） and myocardium/blood ratio（1.79± 0.17） were signilicantly increased （P<0.05） than those of the normal control（3.27± 0.32%ID/g and 1.56± 0.09）. Therefore, BMIPP showed higher myocardialuptake and longer myocardial retention and can refiect myocardial perfusion, so itcan be used as myocardial perfusion tracers for SPECT  
        关键词：Free fatty acid;BMIPP;Dipyridamole;Radionuclide imaging   
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        发布时间：2021-04-09
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