Exploration of D2 receptors and cotent of DA of striatum in hemi-parkinsonism model rats before and after Madopar treatment[J]. Nuclear techniques, 1998, (5): 257-261.
Exploration of D2 receptors and cotent of DA of striatum in hemi-parkinsonism model rats before and after Madopar treatment[J]. Nuclear techniques, 1998, (5): 257-261.DOI:
Exploration of D2 receptors and cotent of DA of striatum in hemi-parkinsonism model rats before and after Madopar treatment
HPLC-ECD were used to study therelationship between D2 receptors and the content of DA
HVA
DOPAC in striatumof hemi-parkinsonism model rats before and after Madopar treatment. After Madopartreatment
the striatum/cerebellum 125I-IBZM uptake ratio of lesioned side was 7.23±0.67
showed 17.22± 3.94% increasing as compared to the contralateral side
theincreasing were significantly declined compared with the pretreatment group andcontrol group (P<0.01). The DA
HVA
DOPAC levels in lesioned side striatum ofMadopar group were increased compared with the other two groups (P<0.05). All ofthe above verified that Madopar treatment can elevate DA levels of lesioned striatumin hemi-parkinsonism model rats
and thus prevent and reverse the up-regulation ofD2 receptors.
Exploration of central dopamine D2 receptors by autoradiography,pathology and functional behaviour observation in rat model with experimental parkinsonism
Preparation of dopamine D2 receptor imaging agent 18F-Fallypride and biodistribution study in mice
Synthesis and fluoro-radiolabelling of dopamine D2 receptor imaging agent 18F-FSABZM
Preparation of 99Tcm-labeled dopamine D2 receptor imaging agent m-Br-p-EBZM
Biological evaluation of 99Tcm-labeled dopamine D2 receptor imaging agent mEBZM
Related Author
王博诚
张天谊
林祥通
林岩松
潘栋辉
罗世能
刘春仪
唐婕
Related Institution
上海医科大学附属华山医院核医学国家重点实验室
Wang Bocheng
Huashan Hospital, Shanghai Medical University, Shanghai 200040)Zhang Tianyi
Jiangsu Institute of Nuclear Medicine,Key Laboratory of Nuclear Medicine,Ministry of Health