Animal experiments of radioiodinated ω-p-iodophenyl pentadecanoic acid

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Animal experiments of radioiodinated ω-p-iodophenyl pentadecanoic acid

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- Animal experiments of radioiodinated ω-p-iodophenyl pentadecanoic acid
- NUCLEAR TECHNIQUES Issue 5, (1998)
- 作者机构：
  
  江苏省原子医学研究所核医学国家重点实验室,无锡,214063
- 作者简介：
- 基金信息：
- DOI：
  CLC： +
- Published：01 May 1998
- 稿件说明：
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[1]吴春英,纪书仁,方平,周翔,何拥军,邹霈.对碘苯代十五烷酸的初步动物实验[J].核技术,1998(05):289-292.

Animal experiments of radioiodinated ω-p-iodophenyl pentadecanoic acid[J]. Nuclear techniques, 1998, (5): 289-292.
[1]吴春英,纪书仁,方平,周翔,何拥军,邹霈.对碘苯代十五烷酸的初步动物实验[J].核技术,1998(05):289-292. DOI：

Animal experiments of radioiodinated ω-p-iodophenyl pentadecanoic acid[J]. Nuclear techniques, 1998, (5): 289-292. DOI：

摘要

为了解脂肪酸代谢显像剂125I－对碘苯代十五烷酸（IPPA）在动物体内的分布、清除等行为，进行了125I－IPPA动物实验。结果表明，大鼠心肌对125I－IPPA的摄取高而快，最大心肌摄取值为4．4ID％／g，半清除时间T1／2α－3．8min；甲状腺摄取低，至120min，甲状腺摄取值仅为0．005ID％／organ．免血药清除T1／2α＝2．7min．125I－IPPA与小鼠体内血浆蛋白结合高而快，体外血浆蛋白给会稳定；异常毒性试验合格，小鼠的耐受量是人的560倍。大鼠体内各主要脏器的摄取和清除、免血药清除、小鼠体内血浆蛋白结合等均呈现第二计数峰。提示125I－IPPA能被大鼠心肌迅速摄取并参与心肌代谢，其代谢产物进入血液，最终由肾脏排泄，几乎没有游离碘的释放，从而降低本底，提高显像的质量。

Abstract

The purpose of this paper was to investigate in vivo behavior of biodistributionand elimination of myocardial viability imaging agent 125I-IPPA. Myocardial uptakeof 125I-IPPA in rats showed a peak of 4.4% of injected dose per gram at 1 min. Thehalf elimination time of myocardium was 3.8 min. The maximal uptake of thyroid wasonly 0.005%ID/organ at 120 min. The initial half time of 2.7 min in rabbits wasobtained from the elimination curve of radioactivity in blood. In vitro binding test for125I-IPPA to HSA showed rather constant level of activation during the two hours.The second peak of extraction was observed in major organs of rat

in rabbits’elimination of radioactivity

in vivo binding test for 125I-IPPA to HSA.

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Related Institution

Department of Nuclear Medicine, Huashang Hospital, Fudan University, Shanghai 200040) JI Shuren LU Chunxiong ZHOU Xiang DING Shiyu CHEN Zhengping

核医学国家重点实验室

江苏省原子医学研究所

Zhongshan Hospital, Shanghai Medical University

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