Evaluation of ischemic/reperfused myocardial viability with <sup>99m</sup>Tc sestamibi

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Evaluation of ischemic/reperfused myocardial viability with ^99mTc sestamibi

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- Evaluation of ischemic/reperfused myocardial viability with ^99mTc sestamibi
- NUCLEAR TECHNIQUES Issue 5, (1998)
- 作者机构：
  
  1. 广东汕头大学医学院附属第一医院
  2. 同济医科大学附属协和医院,武汉,430022
  3. 广东汕头大学医学院附属第一医院同济医科大学附属协和医院,武汉,430022
- 作者简介：
- 基金信息：
- DOI：
  CLC： R14
- Published：01 May 1998
- 稿件说明：
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[1]张成君,张永学.~(99m)Tc-MIBI评价缺血/再灌注心肌活力的实验研究[J].核技术,1998(05):262-266.

Evaluation of ischemic/reperfused myocardial viability with ^99mTc sestamibi[J]. Nuclear techniques, 1998, (5): 262-266.
[1]张成君,张永学.~(99m)Tc-MIBI评价缺血/再灌注心肌活力的实验研究[J].核技术,1998(05):262-266. DOI：

Evaluation of ischemic/reperfused myocardial viability with ^99mTc sestamibi[J]. Nuclear techniques, 1998, (5): 262-266. DOI：

摘要

应用99mTc－MIBI对家兔缺血／再灌注心肌细胞及线粒体代谢和活力进行了评价。将家兔LAD阻断20min、3h再灌注，于灌注后2－5min静脉注射99mTc－MIBI，结果缺血3h组缺血心肌再灌注早期（10min）、晚期（3h）相对放射性活度、心肌ATP含量均明显低于缺血20min组，非缺血心肌和缺血20min心肌99mTc－MIBI亚细胞分布与SDH活性呈显著正相关（r＝0．88，P＜0．001），缺血3h心肌无显著性相关。非缺血心肌和缺血20min心肌线粒体与MIBI结合率明显高于缺血3h心肌，当反应液中加入代谢底物琥珀酸盐后前两者显著增加。非缺血心肌、缺血20min心肌与缺血3h心肌再灌注期心肌99mTc－MIBI动力学存在明显差异，反映心肌活力；心肌摄取99mTc－MIBI与线粒体的结合，反映心肌细胞和线粒体代谢和活力。

Abstract

This study was to evaluate myocardial cell and mitochondrial viability with99mTc-MIBI. In vivo studY

185Mbq 99mTc-MIBI was injected intravnously intorabbits 2-5 min after reperfusion preceded 20 min （Group A） or 3h （Group B） of LADocclusion. In Group B

relative sestamibi activity of ischemic myocardiam andmyocardial ATP contents was significantly lower than Group A; and a significantlypositive correlation between SDH and subcellular sestamibi distribution （r=0.88

P<0.001） was found. In vitro study

the capacity of mitochondria preparation tosequester sestamibi was examined after 20 min as percent of total 99mTc activity. Itwas 9.70 ± 2.59%

10.05 ± 2.00% and only 3.89 ± 1.48% in nonischemic

reversible andirreversble damaged myocardium respectively. After addition of succinate

increasedto 50.27± 12.04%

52.70± 10.97% and 6.08± 3.26%

respectively was observed.Myocardial 99mTc-MIBI mainly localized within mitochondria. Myocardial kinetics of99mTc sestamibi was significantly affected by myocardial metabolism and viability.

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