最新刊期
      卷 0 ， 期 0 ， 2020
      • Issue 11, (1996)
        摘要：Six normal rats were injected intravenously with 99mTc（V ）-DMSA. The blood radioactivity vs. time curve showed that pharmacokinetics of 99mTc（V ）-DMSA accorded with the two compartment open model. The important kinetic parameters were as follows:T1/2（α ）= 3.4min, T1/2（β） = 70.9min, V（c） = 272ml, K21 = 0.058min-1,K10= 0.034min-1 and K12= 0.122min-1. These results indicated the drug was distributed very rapidly and widely from blood to tissues, and its e1Anination was also rapid, eg. an almost complete elimination from blood need only 6-7h. The drug’s existing form in rat blood was studied as well.  
        关键词：?99m)Tc;Dimercaptosuccinic acid;Pharmacokinetics   
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        发布时间：2021-04-09
      • Issue 11, (1996)
        摘要：The rat model with experimental parkinsonism mimic the course of human parkinsonism were made by cerebral-stereotaxic techniques. 125I-IBZM was used to evaluate the D2 receptors distribution by autoradiographic analysis of coronal brain section. In 6 parkinsonism model rats, on the lesioned side the striatum/frontal cortex ratio was 5.32 ± 0.37, it was significantly（P<0.05） higher than the contralateral intact side and the control group, and coincided with the pathological findings and neurological changes. Also, there was a positive correlation between the increased value and numbers of apomorphine induced rotation. All of the above verified that there was an up regulation effect in early parkinsonism, and 125I-IBZM as the ligand of D2 receptor, can well reflect the distribution and changes of D2 receptors, and also as the theoretical basis for the clinical imaging diagnosis.  
        关键词：Parkinsonism;Rat;Dopamine D2 receptor;IBZM;Autoradiography   
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        发布时间：2021-04-09
      • Issue 11, (1996)
        摘要：The rCBF brain SPECT with 99mTc-HMPAO was performed in 15 children with interictal epilepsy, and some cases were compared with EEG, X-ray CT and MRI.The results showed that the positive rate of SPECT was the highest（93.33%,）, thenthe EEG （92.31%）, and the CT and MRI were the lowest（66.67% and 75%）.This study indicated that brain SPECT was an effective method for diagnosis and foci localization in epileptic children, and also was useful to the study of prognosis and relationship between changes of rCBF and progress in clinical pictures.  
        关键词：Epileptic children;Brain;SPECT   
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        发布时间：2021-04-09
      • Issue 11, (1996)
        摘要：Acidic isoferritin（AIF） was isolated and purified from human heart muscle.Antisera against AIF were generated by immunizing rabbits and purified in affinity chromatography column which was conjugated with AIF. The immunogloublins against AIF were made in solid-phase. 125I-monoclonal antibodies against H subunit of AIF（AIF-H） was prepared by the chloramine-T method. The AIF-H solid-phase IRMA was established and the data were processed by the automatic spline function.The intra- and interbatch coefficients of variation were 2.443% and 10.160%respectively. The sensitivity was 0.736 μg/L and the recovery was 92.293%. The measuring range was 1.472-320 μ g/L and ED5o was 23.05 μ g/L. No cross-reaction was observed with AFP, CEA and LF, but there was 3.125% with ferritin. A parallel experiment demonstrated that seruxn matrix had no interference with this method.The level of serum AIF-H in 40 healthy men and women was 3.75 ± 1.85 μ g/L and 2.92± 0.96 μ g/L respectively while it was 8.39± 3.87 μ g/L in 10 patients with hepatoma. This method may therefore provide a valuable tool for diagnosis of tumor, especially for basic and clinical study of hepatoma.  
        关键词：Acidic isoferritin;Immunoradiometric assay;Hepatoma   
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        发布时间：2021-04-09
      • Issue 11, (1996)
        摘要：Radioligand binding assay of gastrin receptor（GR） was established to determine GR content and Kd of gastric cancer and mucosa in specimens of 34 patients. Both of Gs-5 and [len15]Gs-17, as unlabelled ligand, can inhibit the binding of 125I-（leu15）Gs-17to the membrane, and the inhibiting effect of Gs-5 is slightly stronger than that of （len15）Gs-17.Mixed cellulose acetate filters have better effect to separate bound 125I （leu15）Gs-17 from free 125I- （len15）Gs-17 than glass fibre filters （Hongguan 999999）.The GR of gastric cancer correlates with that of mucosa in the same region of 34patients.  
        关键词：Gastrin receptor（GR）;Radioligand binding assay;Gastric cancer   
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        发布时间：2021-04-09
      • Issue 11, (1996)
        摘要：Higher and lower specific activity 131I-MIBG were investigated in normal andreserpinized mice. Biodistribution studies showed a higher uptake of 131I-MIBG in heart with its maXimum of 9.08%ID/g at 4h pi at 3.22TBq/g MIBG,and a lower uptake of 4.8%ID/g at the same take at 18.5GBq/g MIBG. The heart intravesicular uptake is increased with upping specific activity, but the heart extravesicular uptake seems not connect with specific activity. When using MIBG for myocardical imaging,a higher specific activity of 131I-MIBG will be beneficial to diagnosis.  
        关键词：MIBG;Myocardical imaging;Specific activity   
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        发布时间：2021-04-09
      • Issue 11, (1996)
        摘要：The radionuclide angiography of femoral head was measured in 10 normal controls and 12 cases of ischemic necrosis of femoral head （INFH） by fracture using 99mTc MDP bone imaging. The results demonstrated that, in normal subjects the difference of femoral perfusion index（FPI） of both femoral head was <0.2,whereas in INFH group >0.4. The difference of FPI between both groups has statistical significance （P<0.001）.Therefore, the measurement of perfusion index of femoral head has some help for INFH dignosis.  
        关键词：Radionuclide angiography;Blood perfusion;Ischemic necrosis of femoral head   
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        发布时间：2021-04-09
      • Issue 11, (1996)
        摘要：Thirty-three cases of senile Parkinson’s disease（PD） imaged by 99mTc-HM-PAO brain SPECT were reported. 66.7% of the patients had conical hypoperfusion and 18.2% showed asymmetrical hypoperfusion in the hasal ganglia. Such a finding was not related with the Hoehn-Yahr stage and the laterality of motor symtoms. If complicated with dementia, the SPECT brain adaging showed similar pattern inAlzheimer’s disease with diffuse hypoperfusion in conical area reflecting widespread pathological changes in tremor paralyses.  
        关键词：Brain imaging;Parkinson’s disease;SPECT   
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        发布时间：2021-04-09
      • Issue 11, (1996)
        摘要：The portal hypertension of hepatic cirrhosis was studied by 99mTc-MIBI trans-rectum imaging. The portal systemic circulation was evaluated by the heart-liver ratio （H/L ratio） and the portosystemic shunt index （SI）. The H/L and SI in 12 normal cases were 0.145 ± 0.042 and 0.124 ± 0.029. Whereas in 18 patients with hepatobiliary diseases of non-cirrhosis were 0.207 ± 0.076 and 0.169 ± 0.051, and in 47patients with hepatic cirrhosis were 0.751± 0.313 and 0.422± 0.075. The results showed significant difference （P<0.01） between normal controls and non-cirrhosis group, and significant difference （P<0.001） between hepatic cirrhosis group andnormal controls, non-cirrhosis group. A significant difference （P<0.05） in child-pugh’s classification A, B and C group was also found. A significant correlation （r=0.95, P<0.01） with the H/L, SI and portal pressure measurementduring operation was found. If H/L>0.30, and SI≥0.22 were taken as positive criteria for diagnosis of portal hypertension with hepetic cirrhosis, the sensitivity,specificity and accuracy were 96%, 90% and 94% respectively.Therefore, it was a new method for the diagnosis of portal hypertension with hepatic cirrhosis.  
        关键词：?99m)Tc-MIBI;Trans-rectal portal scintigraphy;Hepetic cirrhosis;Portal hypertension;Noninvasive diagnosis   
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        发布时间：2021-04-09
      • Issue 11, (1996)
        摘要：Twenty-two cases of ischemic cerebral vascular disease, diagnosed by clinical and experimental methods, were examined with 99mTc-ECD SPECT regional cerebral blood flow （rCBF） tomography adaging before and after treatment with exterenal counter pulsation （ECP）. Before the treatment, there were 54 segments deficient in rCBF, while after the treatment 20 segments fully improved （37.5%）, 19 segments podly approved （35.2%） and 15 segments not changed （27.8%）.Therefore, totalefficacy reached up to 72.2%（39/54）. The result suggested that SPECT is useful notonly for early diagnosis but also for the evaluation of the curative effect on ischemic cerebral vascular disease.  
        关键词：Ischemic cerebral vascular disease;Regional cerebral blood flow（rCBF）;Radionuclide imaging;External counter pulsation（ECP）   
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        发布时间：2021-04-09
      • Issue 11, (1996)
        摘要：In this article the imaging of 42 cases of pathologically identitied thyroid cancer with 99mTc-MIBI were reported and compare with 131Ⅰ whole body scan, CT, MRI and X-ray plane film. This method is easy and safe with a sensitivity of 97%. Comparing with fall scan, it has 4 advantages:1.The methods is not influenced by iodine-rich food, medicine or related hormone. 2.The thyroid cancer tissue with or without accumulation of 131Ⅰ can all be imaged. 3.The radiation injury is quite low. 4.99mTc-MIBI study is more rapid, it can be performed 30 min after iv injection.Moreover 99mTc-MIBI can be used as a reference for the course of disease.  
        关键词：Thyroid cancer;￣（131）Ⅰimaging;Treatyment;MIBI   
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        发布时间：2021-04-09
      • Issue 11, (1996)
        摘要：The radioiodine labelled compound of rhG-CSF was prepared using the chloramine T method and the pharmacokinetics of 125Ⅰ-rhG-CSF was studied by intravenous injection with three doses.  
        关键词：rhG- CSF;Radioiodine labelling;Pharmacokinetics   
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        发布时间：2021-04-09
      • Issue 11, (1996)
        摘要：Left ventricular（LV） and right ventricular（RV） function were determined using radionuclide ventriculography in 50 patients with hyperthyroidism. LVEF, LVPFR,SV of the hyperthyroidism group were decreased in comparison with the normal group （P<0.01）, whereas CO of the hyperthyroidism patients were higher than that of normal （P<0.01）. Except LVPER, the LVEF, SV had significant difference between two groups. Compared to normal group, RVEF, RVPER, RVPFR were also decreased（P<0.01）. Besides 30 cases of the hyperthyroidism were examined by impedancecardiogram（ICG） and impedance pulmonary rheogram（IPR）, all showed closely correlation with the parameters determined by ventyiculography. There was the involvment of right ventricular function insufficiency,especially in ejection phase.When compared with pre-therapy and pos-therapy cases showed significant improvement in EF, PER, PFR of left and right ventriculars.  
        关键词：Radionuclide ventriculography;Impedance cardiogram impedance pulmonary rheogram;Hyperthyroidism;Cardiac function determination   
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        发布时间：2021-04-09
      • Issue 11, (1996)
        摘要：A microwave method reconstructing 99mTc-sestamibi was reported.The optimum condition was heating 15s at medium（940W） pewer in a microwave oven. The radiochemical purity of the 99mTc-sestamibi was over 95%, measured by a γ counter.The recommended thin-layer chromatography system involved. the use of a polyamide-coated plate and acetonitrile as developing solvent. The microwave ovenheating method will facilitate the emergency use of 99mTc-sestamibi.  
        关键词：m)￣Tc-sestamibi;Microwave;Radiochemical purity   
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        发布时间：2021-04-09
      • Issue 11, (1996)
        摘要：After submaxdrial stress, 99mTc-MIBI（740MBq） was intravenously administered in 33 cases of coronary heart diseases.Planer myocardial imaging was performed 1h later. Lung/heart ratio was determined using ROI technique. The result showed that there was very significant difference between the lung/heart ratio of angina pectoris and myocardial infarction group compared with the normal controls （P<0.01）. If 0.38 as marker for severe coronary artery disease was used, then the sensitivity was 87.5%, specificity 100% and accuracy 93.3%. In our study, these were 7 cases withlung/heart ratio >0.38. This accounted for 21.2%. In all these cases, the myocardial imaging were positive, with ischemia in more than two walls. Thereby lung/heart ratio was clinically useful for determining the seventy and prognosis of coronary artery disease.  
        关键词：Coronary artery disease;Radionuclide imaging;Cardiac function test;Isonitriles   
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        发布时间：2021-04-09
      • Issue 11, (1996)
        摘要：The effect of splenectomy on reticuloendothelial system（RES） function was investigated by measurement of 99mTc-phytate in the presence or absence of sepsis in rats, and plasma fibronectin（PFn） and hyaluronic acid（HA） concentrations were measured. The results were as follows: following splenectolny, particularly in the presence of sepsis, the intravascular clearance（TI/2） delayed and HA increased, phagocytic index（K） and hepatic uptake and PFn decreased. These results suggest that splenectomy may not only have deleterious effects in terms of the host defencesystem, but may also cause RES depression due to the postsplenectomy infection.  
          
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        发布时间：2021-04-09
      • Issue 11, (1996)
        摘要：Fifty-one cases of chronic obstructive pulmonary disease（COPD） were studied with 99mTc-MAA pulmonary perfusion and 99mTc-DTPA ventilation imaging. The results showed both studies have good matcH and .their positive rate was 96.0%（49/51）.It was much higher than X-ray chescfilm （56.8%）and better than pulmonary localization function study（843%）. A)lo fo was proved that they can increase early detecting rate of COPD and provide ac strong evidence for early diagnosis, evaluating the course and therapeutic feefct of disease.  
        关键词：Radionuclide imaging;Pulmonary localization diagnosis;Chronic obstructive pulmonary disease   
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        发布时间：2021-04-09
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