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福建省立医院
Published:01 November 1996
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[1]唐明灯,董惟誉,刘用华,何品玉,李珍儿.核素直肠-门脉显像对肝硬化门脉高压的诊断价值[J].核技术,1996(11):665-668.
A study of trans-rectal portal scintigraphy for the diagnostic evaluation of portal hypertension with hepatic cirrhosis[J]. Nuclear techniques, 1996, (11).
应用99mTc-MIBI直肠灌注进行门脉显像,根据心肌及肝区放射性计数测定核素心、肝比值H/L和门体分流指数SI作为门静脉循环参数与术中门静脉测压等指标作统计学处理。12例正常对照组的HIL为0.145±0.042,SI为0.124±0.029;18例非肝硬化性肝胆疾病组的H/L为0.207±0.076,SI为0.169±0.05(p均<0.01);47例肝硬化组的H/L为0.751±0.313。SI为0.422±0.075(与对照组及非肝硬化性肝胆疾病组比较P均<0.001);根据Child-pllgh分级的A、B、C三组间的差异亦有显著意义(P均<0.05)。H/L、SI与术中测压呈高度正相关(r=0.95,P<0.01)。以H/L≥0.30、SI≥0.22为阳性,诊断肝硬化门脉高压的灵敏度为96%、特异性为90%、准确性为94%。表明本方法可作为诊断肝硬化门脉高压的新方法。
The portal hypertension of hepatic cirrhosis was studied by 99mTc-MIBI trans-rectum imaging. The portal systemic circulation was evaluated by the heart-liver ratio (H/L ratio) and the portosystemic shunt index (SI). The H/L and SI in 12 normal cases were 0.145 ± 0.042 and 0.124 ± 0.029. Whereas in 18 patients with hepatobiliary diseases of non-cirrhosis were 0.207 ± 0.076 and 0.169 ± 0.051
and in 47patients with hepatic cirrhosis were 0.751± 0.313 and 0.422± 0.075. The results showed significant difference (P<0.01) between normal controls and non-cirrhosis group
and significant difference (P<0.001) between hepatic cirrhosis group andnormal controls
non-cirrhosis group. A significant difference (P<0.05) in child-pugh’s classification A
B and C group was also found. A significant correlation (r=0.95
P<0.01) with the H/L
SI and portal pressure measurementduring operation was found. If H/L>0.30
and SI≥0.22 were taken as positive criteria for diagnosis of portal hypertension with hepetic cirrhosis
the sensitivity
specificity and accuracy were 96%
90% and 94% respectively.Therefore
it was a new method for the diagnosis of portal hypertension with hepatic cirrhosis.
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