Pharmacokinetic studies on ￣（99m）Tc（V ）-DMSA in rats

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Pharmacokinetic studies on ￣（99m）Tc（V ）-DMSA in rats

更新时间：2021-04-09

- Pharmacokinetic studies on ￣（99m）Tc（V ）-DMSA in rats
- NUCLEAR TECHNIQUES Issue 11, (1996)
- 作者机构：
  
  重庆医科大学
- 作者简介：
- 基金信息：
- DOI：
  CLC： TL923
- Published：01 November 1996
- 稿件说明：
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[1]颜学先,李少林.~（99m）Tc（V）－DMSA大鼠体内药代动力学[J].核技术,1996(11):683-685.

Pharmacokinetic studies on ￣（99m）Tc（V ）-DMSA in rats[J]. Nuclear techniques, 1996, (11).
[1]颜学先,李少林.~（99m）Tc（V）－DMSA大鼠体内药代动力学[J].核技术,1996(11):683-685. DOI：

Pharmacokinetic studies on ￣（99m）Tc（V ）-DMSA in rats[J]. Nuclear techniques, 1996, (11). DOI：

摘要

用改良方法成功制备了五价锝标记的二巯基丁二酸（９９ｍＴｃ（Ｖ）－ＤＭＳＡ）。根据血样时间－放射性曲线，该药在大鼠体内的代谢符合开放型二房室模型。主要动力学参数为Ｔ１／２（α）＝３．４ｍｉｎ，Ｔ１／２（β）＝７０．９ｍｉｎ，Ｖ（ｃ）＝２７２ｍｌ，Ｋ２１＝０．０５８ｍｉｌ－１，Ｋ１０＝０．０３４ｍｉｎ－１，Ｋ１２＝０．１２２ｍｉｎ－１。结果表明，９９ｍＴＣ（Ｖ）－ＤＭＳＡ从血液向组织的分布速度快，分布范围极广，体内消除迅速，基本从血中清除仅需６—７ｈ．为该显像剂的临床应用提供了实验基础。还研究了该药在大鼠血中的存在形式。

Abstract

Six normal rats were injected intravenously with 99mTc（V ）-DMSA. The blood radioactivity vs. time curve showed that pharmacokinetics of 99mTc（V ）-DMSA accorded with the two compartment open model. The important kinetic parameters were as follows:T1/2（α ）= 3.4min

T1/2（β） = 70.9min

V（c） = 272ml

K21 = 0.058min-1

K10= 0.034min-1 and K12= 0.122min-1. These results indicated the drug was distributed very rapidly and widely from blood to tissues

and its e1Anination was also rapid

eg. an almost complete elimination from blood need only 6-7h. The drug’s existing form in rat blood was studied as well.

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