Intra- and extravesicular accumulation as function of ￣（131）I-MIBG specific activity in mouse heart

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Intra- and extravesicular accumulation as function of ￣（131）I-MIBG specific activity in mouse heart

更新时间：2021-04-09

- Intra- and extravesicular accumulation as function of ￣（131）I-MIBG specific activity in mouse heart
- NUCLEAR TECHNIQUES Issue 11, (1996)
- 作者机构：
  
  解放军总医院
- 作者简介：
- 基金信息：
- DOI：
  CLC： TL75
- Published：01 November 1996
- 稿件说明：
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[1]张锦明,田嘉禾,刘自来.~（131）Ⅰ—MIBG比活度对鼠心肌交感神经囊泡内外摄取的影响[J].核技术,1996(11):649-652.

Intra- and extravesicular accumulation as function of ￣（131）I-MIBG specific activity in mouse heart[J]. Nuclear techniques, 1996, (11).
[1]张锦明,田嘉禾,刘自来.~（131）Ⅰ—MIBG比活度对鼠心肌交感神经囊泡内外摄取的影响[J].核技术,1996(11):649-652. DOI：

Intra- and extravesicular accumulation as function of ￣（131）I-MIBG specific activity in mouse heart[J]. Nuclear techniques, 1996, (11). DOI：

摘要

研究了两种比活度的１３１Ⅰ－ＭＩＢＧ在正常及利血平抑制后在鼠体内的分布，结果表明：注射后４ｈ，正常鼠心肌对３．２２ＴＢｑ／ｇ的ＭＩＢＧ摄取为９．０８％ＩＤ／ｇ，明显高于对１８．５ＧＢｑ／ｇ的摄取（４．８７％ＩＤ／ｇ）。计算表明，比活度主要影响了鼠心肌交感神经囊泡内摄取，而与囊泡外摄取无关．当ＭＩＢＧ用于心肌显像时，高比活度的ＭＩＢＧ有利于诊断。

Abstract

Higher and lower specific activity 131I-MIBG were investigated in normal andreserpinized mice. Biodistribution studies showed a higher uptake of 131I-MIBG in heart with its maXimum of 9.08%ID/g at 4h pi at 3.22TBq/g MIBG

and a lower uptake of 4.8%ID/g at the same take at 18.5GBq/g MIBG. The heart intravesicular uptake is increased with upping specific activity

but the heart extravesicular uptake seems not connect with specific activity. When using MIBG for myocardical imaging

a higher specific activity of 131I-MIBG will be beneficial to diagnosis.

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