最新刊期
卷 0 ， 期 0 ， 2020
- 摘要：To determine whether the reversible opening of blood-brain barrier is able to increase the brain uptake of 99m Tc-TRODAT-1; Adult Sprague-Dawley rats were infused with mannitol via femoral vein at rates 0.25mL/kg·s for opening blood-brain barrier,GBR12909 was used to characterize the pharmacological specificity of 99m Tc-TRODAT-1 for dopamine transporters after infusion of mannitol. After infusion of mannitol,the brain uptake of 99m Tc-TRODAT-1 showed a dramatic increase,but no effect on striatum/cerebellum and pharmacological specificity of 99m Tc-TRODAT-1. This study shows that the reversible opening of blood-brain barrier with mannitol may be a useful approach to improve brain uptake of 99m Tc-TRODAT-1 and other 99m Tc-labeled specific receptor imaging agents.关键词：Reversible opening of the blood-brain barrier;Dopamine transporter;TRODAT-1
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发布时间：2021-03-12 - 摘要：To investigate the clinical features of complicated with pulmonary embolism nephrotic syndrome in children. 99m Tc-MAA pulmonary perfusion imaging was performed on 30 nephrotic syndrome in children with elevated plasma D-dimer. Results shown that 14 of 30 patients were found to have pulmonary embolism (46.7%). Pulmonary perfusion imaging showed an involvement of 1 pulmonary segment in 3 cases, 2 segments in 2 cases and over 3 segments in other 9 cases. Among them, there were 7 segments involved in one case. After two weeks of heparin anticoagulative therapy, most cases showed a recovery. The result of this study suggested that pulmonary embolism is a common complication of nephrotic syndrome. Pulmonary perfusion imaging is simple, effective and accurate method for the diagnosis of pulmonary embolism, and it also can help to assess the value of clinical therapy.关键词：Nephrotic syndrome;Pulmonary embolism;Radionuclide imaging
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发布时间：2021-03-12 - 摘要：Bone mineral density (BMD) of calcaneus in 54 normals, 45 Osteoporosis, 25 suspected osteoporosis and 16 other non-osteoporosis patients, a total of 140 cases were measured by HUAKE (HK-1) 241-Americium BMD absorpmetry, among them 43 were compared with that of lumber spine (L2—L4) measured by Lunar Corporation’s Expert-XL absorpmeter. BMD of normal group of calcaneus was (409.8±79.4)mg/cm 2. The BMD were decreased slowly with the increased age. The BMD of osteoporosis, suspected osteoporosis and non-osteoporosis group were 230.3±62.3, 395.7±57.4 and 363.3±51.9mg/cm 2 respectively. The BMD of osteoporosis group was much lower than that of normal group, and also lower than that of the other two groups, among 26 patients (57.78%) had bone fracture, all was in accordance with the clinical diagnosis of osteoporosis. The BMD of suspected ospteoporosis and non-osteoporosis had no significant difference with normal group. The coefficient variation (CV) of BMD in repeated measurement in calcaneus of 4 pariticipants was less than 1.2%. The correlative coefficient ( r ) between BMD of calcaneus and lumber spine (L2—L4) group was 0.6824. The correlative coefficient of normal young adult-matched percentage and T value in 2 groups were 0.6863 and 0.6755 respectively, whereas aged-matched percentage, Z value were 0.4614 and 0.5009 respectively. In conclusion 241-Americium calcaneus BMD absorpmetry has the advantage of low price, easy to operate, reliable and valuable in diagnosis osteoporosis. The correlations of calcaneus and lumber spine BMD, normal young adult-matched percentagy and T value were rather good.关键词：Bone mineral density;Osteoporosis;241-Americium;Dual energy X-ray absorpmetry;Correlative analysis
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发布时间：2021-03-12 - 摘要：According to the requirements of department of special drug, bureau of drug administration, Chinese ministry of health, To testify the safety and efficiency of metastron injection solution imported from the Amersham Company, U.K. being underged. 27patients were treated with metastron for metastatic bony pain(MBP). 2 cases were excluded by interrupted follow-up, the other 25 cases with metastatic prostate carcinoma, lung cancer, breast cancer were evaluated in a standard quantitative pain measurement before the treatment.Pain scores of these patients were between 6—16. 1.48MBq/kg metastron was given intravenous. All the patients were observed at least 3 months. Pain score, immediate adverse reaction were observed . Results shown that clinical significant metastastic pain relief can be observed in most patients. Total efficiency was 72%, patients’ life quality have been improved. There was mild decrease of white blood cell in 32% and platelet counts in 60% patients, but can recovered in most patients temperary except 1. In this case, liver function abnormal was also appeared. Significant increased pain (flare) occurred in 55.5% patients after the injection, the flare up pain had been lasting 3—7days, only one lasting more than 20 days. It was concluded that 89 Sr is most effective in palliative therapy for MBP in-patient with prostate or breast carcinoma. In 94.4 % patients , the pain relief can lasted more than 3 months, but only one patient for 2 months.7 cases had repeated the bone scan after therapy,but no significant changes can be observed. There by 89 Sr was safe and effective for the treatment of MBP.关键词：Bone metastases;Bone pain;Radionuclide treatment
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发布时间：2021-03-12 - 摘要：The aim of this work is to compare the toxicity and efficacy of three-step pretargeting radioimmunotherapy involving administration of a biotinylated anti-carcinoembryonic antigen (CEA) antibody, followed by avidin followed finally by 153 Sm labelled biotin with 153 Sm directly labelled anti-CEA monoclonal antibody(McAb). CEA McAb and DTPA-biocytin (DB 2) was labelled with 153 Sm using the bifunctional chelate cyclic diethylenetriaminepentaacetic acid (DTPA) anhydride. Five groups of nude mice subcutaneously grafted with human colon carcinoma were treated 3 days after the graft. One group received the injection of 100μg McAb-Bt followed 2 days later by cold Av (80μg)and 11.1MBq 153 Sm-DB 2 after a further day. Four control groups were treated respectively with (1) 11.1MBq 153 Sm-CEA McAb, (2) 11.1MBq 153 Sm-mIgG, (3) 11.1MBq 153 Sm-DB 2, (4) 100μL physiological sodium chloride solution. Toxicity was evaluated by change of body weight and number of leukocytes, and efficacy was evaluated by variation in tumor volume. Histological analysis of tumors were performed. The results showed that pretargeting RIT and 153 Sm-CEA McAb had a strong tumor inhibition effect. The inhibitory rates of tumor were 80.67% and 78.44% respectively, five weeks after therapy. Histopathological evidence indicated that in tumor tissues radioactive damage was seen as necrosis of tumor cells, while in the other tissues such as liver and kindey tissues no radioactive damage was observed. Leukocyte counts were singnificantly decreased after treatment in groups of 153 Sm-CEA McAb and 153 Sm-mIgG, which indicated that the haemopoitic function of bone marrow may be affected. It was concluded that three-step pretargeting radioimmunotherapy was as efficient as 153 Sm-CEA McAb but was markedly less toxic.关键词：Pretargeting-radioimmunotherapy;Avidin-biotin system;153 Sm label
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发布时间：2021-03-12 - 摘要：To evaluate the safety and efficacy of 89 SrCl 2 in the treatment of painful skeletal metastases of cancer patients. 25 metastatic bony pain patients received 1.48—2.22MBq/kg 89 SrCl 2 intraveneously. After therapy the white blood cell, platelet count, liver and renal function was measured every two weeks during 8—12 weeks. The pain relier and adverse effect were also observed and dose was carried out after 3 months or re-occurrence of pain. Results shown that, pain relief was observed in 18 of 25 patients, among them, complete relief in 4, improved in 14 and no relief in 7. The bony pain responded well in prostate cancer and breast cancer (4/4 and 6/8 respectively), and also effective in repeat treatment (6/6). Pain relief begin from 2—14 days and the duration of pain relief was 12—36 weeks. The toxicity was mild, only transient and restricted to hematological toxicity (<grade II). No adverse reaction, such as bleeding, gastrointestinal symptom and anaphylaxis had been found 5 of 25 patients had pain flar. Conclusions 89 SrCl 2 was an pain-relief agent for skeletal metastases. It can improve the quality of life in the patients and was sate and valuable for clinical use.关键词：Radiotherapy;Bone metastases;89 SrCl 2
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发布时间：2021-03-12 - 摘要：Clinical application of 80 patients treated with 89 Sr for metastatic bony pain was reported the toxic effet and dosage was also evaluated. Of the 17 cases with complete blood sample examination, 7 cases with the dosage of 1.11—1.48MBq/kg showed no changes in leukocyte and platelet count. 10 cases with the dosage of 1.48—2.22MBq/kg showed slight decline 14% and 23% respectively in leukocyte and platelet count. 5—6 weeks after 89 Sr treatment. As to the pain relief 25 cases 31.25% complete pain free (grade 4), 34 (42.5%) are of significant pain decrease (grade 3), 13 (16.25%) are of slight pain decrease (grade 2), 8 (10.0%) are of no change or even pain aggravated (grade 1), the total efficacy of 89 Sr was 90.0% and the significant efficacy (complete pain free + significant pain relief) was 73.75%. The optimal dose of our study was within the range of 1.11—1.48MBq/kg. Thereby, it was concluded 89 Sr was effective for relief of the metastatic bony pain.关键词：Radiotherapy;Bone metastasis;Strontium-89
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发布时间：2021-03-12 - 摘要：To observe the clinical value of 131 I in the treatment of hyperthyroidism. The weight of the thyroid was evaluated by palpation, 131 I was taken orally by one dose method. The dose was calculated by actual absorption of 131 I/per gram of thyroid. 3—6 months after drug administration, the symptom, clinical manifestation and the serum hormone of the pituitary-hypothyroid axis were observed. In 105 cases, 80(76.2%) were nearly recovered, among them 16(15.2%) had hypothyroidism in the early period. The allover recovering rate was 91.4% in one dose, but 9(8.6%) were recurred and can be controlled at a second dose. Therefore 131 I for the hyperthyroidism had a high recovering rate, low recurring rate and was very convenient. If the dose at an optimal range was controlled. The occurrence of hypothyroidism can be reduced to the acceptable level.关键词：Iodine;Hyperthyroidism
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发布时间：2021-03-12 - 摘要：To evaluate the role of the right lateral (RL) imaging in the attenuation correction of left ventricular inferior wall. The RL imaging were obtained immediately after the supine imaging. The inferior wall configuration and regional myocardial counts were assessed by tomography imaging and quantitative polar map analysis for 31 normal controls and 22 coronary artery disease patients all with coronary arteriography. The results were compared between the two imagings. The sensitivity and specificity of diagnosis were compared by both imagings. Results shown that better configuration and higher inferior myocardial counts per pixel were observed in the RL than in supine imaging ( P <0.05). Right CAD sensitivity and specificity of lesions for supine imaging were 90.0% and 63.6%, whereas 100% and 81.8% respectively for RL imaging. The RL imaging can well collect the attenuation of inferior wall and improve diagnostic accuracy the right CAD lesions.关键词：Myocardial perfusion;99m Tc-MIBI;Right lateral;Inferior;Myocardial infarct
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发布时间：2021-03-12 - 摘要：Salivary glands can accumulate 131 I and may demage its function during 131 I treated thyroid cancer. The purpose of this study is to understand the extent of the injury and its relation with dosage after high-dose radioiodine therapy. Radionuclide dynamic imaging is used to quantitatively calculate the absorption rate and excretion rate of salivary glands. There was no significant difference between patients group and normal controls in absorption rate ( P >0.05), but there exieted difference in excretion rate ( P <0.05). Absorption rate and excretion rate decreased as the therapy dosage increased and significant difference existed in the >37MBq group with dosage but among the groups with dosage <37MBq. Only the excretion rate had significant difference ( P <0.05). Submandibular glands were less injuried comparing with parotid glands. Salivary glands function showed nearly normal or slightly injurled among young patients and those who received lower therapy dosage. It was concluded that quantitative radionuclide image can measure the absorption and excretion rate of salivary fland to reflect the function and injury extent. Therefore provided an evidence for clinical diagnosis. the injury extent was positively comelated to the dosage of 131 I treatment.关键词：Thyroid cancer;131 I treatment;Salivary glands;Radiation-induced injury
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发布时间：2021-03-12 - 摘要：To evaluate cerebral blood flow perfusion SPECT imaging in SLE brain invovlement. Cerebral blood flow perfusion SPECT imaging was performed in eighteen SLE patients and 11 controls. The results were analyzed by vision and semiquantitative comparison. Five of them performed CT and/or MRI scan also. The sensitivity of SPECT imaging by vision and semiquantitative analysis was 67.7%, and 70% respectively and only 20% for CT scan. Cingulate gyrus and temporal-parietal was most involved area under unpaired t -test. The sensitivity of cerebral blood flow perfusion SPECT imaging was high, but lack of specificity.关键词：SLE;Cerebral blood flow perfusion imaging;SPECT
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发布时间：2021-03-12 - 摘要：A two-site time-resolved fluoroimmunoassay (TRFIA) of CA 125 based on the direct sandwich technique has been developed, with the equilibrium method. The monoclonal antibody (MoAb) against CA 125 was labelled with europium by the help of europium-chelate of diethylenetriaminepentaacetic acid (DTPA). The luminescent enhancement system was an enhancement solution that contained mainly of 2-naphthoyltrifluoroacetone. The intra- and inter- assay CV of the TRFIA were 4.5% and 4.0%, respectively, and the recovery rate was 96.7%, the sensitivity was 3.3μg/mL. The cross-reacting rate with CEA was negligible, and that with AFP and β-HCG was 4.6% and 12.4%, respectively. Compared with the imported IRMA Kit, the correlation coefficient was 0.999.关键词：Carbohydrate antigen(CA);Time-resolved fluoroimmunoassay;Monoclonal antibody;IRMA
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发布时间：2021-03-12 - 摘要：The aim of this work is to measure the collimator’s quality with system uniformity parameter. According to the NEMA standards publication (No. NU 1-1994), four low energy general purpose parallel hole collimators and four low energy high resolution parallel hole collimators had been measured for the system flood field uniformity, the system spatial resolution and system planar sensitivity, and then all of the results were analysed. Results showed that the system spatial resolution and system planar sensitivity parameters of the same type collimators were almost close to each other, but the uniformity parameters were greatly different (when the collimators have quality defect), three of the eight collimators with which the system integral uniformity and differential uniformity exceed by 6% and 3% were proved to be detective in quality. This indicated that the performance of collimator can be reflected quantitatively and qualitatively by the uniformity measurement, and the quality of collimator can be found through it effectively.关键词：Gamma camera;Collimators;System uniformity;System spatial resolution;System planar sensitivity
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发布时间：2021-03-12 - 摘要：Isodose curves for 125 I ophthalmic application in different geometry and activity can be obtained using the empirical formula based on suitable geometric model. The results of surface dose rate determined with lithium fluoride (LiF) thermoluminescent dosimeter (TLD’s) chips in water-organic glass phantom and air had no obvious difference and the surface dose rate and its uniformity, (3.46±0.011) and (0.178±0.15)nGy/h·10 7Bq were obtained. Count measurements and dose determinations for the front and back etc. of the ophthalmic applicator with BaF 2 scintillation detector and LiF TLD’s had revealed the space distribution of dose for 125 I ophthalmic applicator in which dose on the back was less than 0.1% of that on the front. The distribution of the absorbed dose rate along the eye axis had been measured using LiF TLD’s in water-organic glass phantom. The measured and calculated dose data indicated that when measuring distances were larger than about 5mm the experimental results agreed with those from calculation within the range of error, otherwise the measured values were lower, still it could be explained by experimental conditions.关键词：I;Ophthalmic applicator;Dosimetry;Measurement;Calculation
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发布时间：2021-03-12 - 摘要：Through the comparative study of biodistribution of monoclonal antigranulocyte antibody and HIG in inflammatory model rats, the difference of biodistribution of these two kinds of agents in inflammatory model rats were compared. The results showed that both McAb and HIG had much accumulation in liver, spleen and marrow. The accumulation in McAb group was higher than that in HIG group, the difference between the two groups was statistically significant ( P <0.01); McAb group showed lower radioactivity than HIG group in lung, stomach, intestine and muscle; McAb group has significant lower radioactivity than HIG group in blood and the radioactivity in blood disappeared rapidly in McAb group; the kidney accumulated very much radioactivity in two groups. The difference of the ratio of %ID between inflammatory limb (target) and contralateral healthy limb (no target) (T/NT) was insignificant in two groups at six and nine hours after injection of antibody, but McAb group owned higher T/NT ratio than HIG group at twenty-four hours, the difference has statistical significance ( P <0.05). The McAb was able to image the inflammatory sites in inflammatory limb, but the superiority of McAb was less obvious than HIG at early stage. McAb is more suitable to image the inflammatory sites in lung, stomach, intestine and muscle than HIG.关键词：Monoclonal antigranulocyte antibody (McAb);Inflammation;Human immunoglobulin (HIG);Radioimmunoimaging
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发布时间：2021-03-12 - 摘要：To investigate the improved clearance effect of avidin(Av) and streptavidin-gal (SA-gal) for blood radiolabeled biotinylated antibody in pretargeting radioimmuno therapy (RIT) of colon carcinoma xenograft models. Biotinylated antibody radiolabeled with 131 I was injected into the nude mice bearing the colon carcinoma via the tail vein. 24h later, in 2 test groups, SA-gal or Av at a 10-fold molar excess of antibody was intraperitoneally injected into the animals whereas no any chase agents were given to the control animals. Animals were killed for biodistribution study at 30h after 131 I-labeled biotinylated antibody administration. Results showed that Av and SA-gal took the effect of chase very fast. At 6h after injection, the blood level of radioactivity decreased very fast. The tumor/blood raios of control group, Av chase group, SA-gal chase group were 0.42, 2.09, 5.23 respectively, P <0.05 and P <0.01 for the latter two groups as compared other control groups. Compared with Av, SA-gal showed better chase effect, its T/B ratios was 5.23, significantly higher than 2.09 of Av ( P <0.01). In the tissue biodistributions, relatively high non-specific radioactivity uptakes in non-liver organs were seen in Av chase group. Utilized in pretargeting RIT, both Av and SA-gal could make the blood level of radioactivity decrease quickly and considerably improves tumor T/NT ratios. The chase effect of SA-gal was superior to that of avidin.关键词：Streptavidin-gal;Avidin;Pretargeting radioimmunotherapy;Tumor xenograft models
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发布时间：2021-03-12 - 摘要：To assess the influence of isometric handgrip exercise on left ventricular function by radionuclide ventriculogrphy in patients with coronary artery disease (CAD). Using gated equilibrium radionuclide ventriculography, parameters of left ventricular function were andalyzed at rest and during 30% sustained handgrip (HNG) for 5—10 minuets in 8 normal control subjects and 38 consecutive CAD patients. All investigated subjects were also performed coronary arteriography within 2 weeks. Results showed that at rest, left ventricular ejection fraction (LVEF), peak filling rate (PFR), end-diastolic volume (EDV), end-systolic volume (ESV) and heart rate (HR) were reduced in one-vessel, two-vessel and three-vessel of stenosis patient group (53.67±5.0)%, (52.47±8.26)%, (52.81±8.89)%;2.87±0.29, 2.71±0.88, 3.07±0.71 end-diastolic volume per second (EDV/s); 1.36±0.05, 1.34±0.06, 1.34±0.06; 0.62±0.06, 0.66±0.06, 0.65±0.1; 69.67±8.14, 72.85±10.5, 76.56±18.04(min -1 ), respecively, as compared with controls (57±10.45)%,p=NS;2.94±0.44 (EDV/s),p=NS;1.38±0.15,p=NS;0.59±0.11,p=NS;72.88±8.25 (min -1 ),p=NS,respectively. During HNG exercise using both hands, the indexes were reduced in CAD patients (54.44±5.66)%, (48.84±8.70)%, (45.25±8.69)%;2.75±0.39, 2.50±0.68, 2.22±0.58 (EDV/s);1.36±0.05, 1.31±0.06, 1.26±0.07;0.61±0.07, 0.69±0.06, 0.71±0.09;81.33±8.92, 84.46±14.29, 90.56±26.54 (min -1 , respectively, as compared with controls (59.38±9.44)%,p=NS;<0.05,<0.01;3.52±0.33 (EDV/s), P <0.001, P <0.001, P <0.001;1.41±0.16,p=NS;NS,<0.05;0.56±0.11,p=NS;<0.01/<0.01;83.75±7.56 (min -1 ),p=NS, respectively. The four protocols of CAD diagnosis were 1.LVEF<55% and ΔPFR<0 EDV/s at rest (Δ value=during HNG value-rest value);2.LVEF<55% during HNG and ΔPFR<0 EDV/s;3. ΔLVEF<0% and ΔPFR<0 EDV/s;4.ΔEF<0%. Their sensitivity, specificity and accuracy were 45%, 53%, 66%, 76%;100%, 100%, 87.5%, 87.5%;54%, 61%, 70%, 78%, respectively. The isomeric exercise radionuclide ventriculogrphy is a safte, accurate, simple and effective method to evaluate CAD.关键词：Isometric exercise;Cardiac function;Coronary artery disease;Radionuclide imaging
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发布时间：2021-03-12 - 摘要：To observe the density changes of the dopamine transporters (DAT) and receptors in MPTP treated mouse model. Mice ( n =30) were given i.v. injections of 30mg/kg MPTP for 1, 3, 5, 7 days respectively, and in vivo autoradiographic experiments were performed in the striatum using β-CIT for DAT, and IBZM for D 2R. Results showed that a significant decrease of 125 I-β-CIT binding was observed in the early phase, while no dramatic change occurred in 125 I-IBZM binding, but D 2R showed supersensitivity in the later stage. Thus combined imaging of DAT and D 2R may provide a valuable information for clinical and differential diagnosis of PD and assessment of the magnitude of degeneration of nigrastriatum.关键词：CIT;IBZM;Dopamine transporter;Dopamine D 2 receptor;Autoradiography
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发布时间：2021-03-12 - 摘要：Deoxy-2- 18 F-fluoro-D-glucose ( 18 F-FDG) was synthesized via nuclear reaction 18 O(p,n) 18 F and nucleophilic substitution reaction by PET trace Cyclotron-FDG Synthesis System. The corrected radiochemical yield was about 54% and the radiochemical purity was above 95% by HPLC and TLC. The distribution of 18 F-FDG in mice showed that the higher uptake rates of 18 F-FDG in heart and brain were found, the radioactivity reteined in heart and brain for longer time and the radioactivity in kidney was rapidly cleared. The radioactivity in blood and organs dropped very slowly 30min after injection of 18 F-FDG. The synthetic 18 F-FDG allowed for PET study and diagnosis of patients.关键词：F-FDG;Synthesis;Distribution in vivo
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发布时间：2021-03-12 - 摘要：Sm-Pingyangmycin has been prepared by the reaction of 153 SmCl 3 and Pingyangmycin. When the labeling condition was 1mg Pingyangmycin, pH 5—6, 30min reaction time, the labelling yield was greater than 98%. The in vitro stability of 153 Sm- Pingyangmycin was good in 72h. The results of the tissue distribution in Sarcomas-180 mice showed that tumor uptake at 3h after injection was (1.615±0.219)%ID/g and femur uptake at 6h was (16.142±3.501)%ID/g. The ratios of tumor/blood and femur/blood at 24h were 48 and 908 respectively. 153 Sm-Pingyangmycin may be used for the treatment of tumor and bone tumor.关键词：SmCl 3;Pingyangmycin;Sarcomas-180
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发布时间：2021-03-12 - 摘要：F-Fluorouracil were successfully labeled and synthesized using direct labeling method by 18 F/F 2 and Uracil. It was used for evaluating 18 F-FU-PET imaging for the colorectal carcinoma patients with liver metastases before and after chemotherapy. The radiochemical purity was above 95%, the radiochemical yield was about 60%, pH value was about 7 and both sterility and apyrogenicity test showed negative result. All these results guarantee its potential clinical usage.关键词：Colorectal Cancer;Positron emission tomography (PET);5- 18 F-Fluorouracil
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发布时间：2021-03-12 - 摘要：It is of great importance to study the preparation of radiopharmaceuticals for brain receptor imaging with PET, among which Fluorine-18 was used as the radionuclide in many of these radiopharmaceuticals. This paper reviews the common methods for preparing Fluorine-18 labelled radiopharmaceuticals for brain receptor imaging, with particular emphasis on nucleophilic routes. Some progresses on the preparations of the radiopharmaceuticals classified according to the corresponding receptors were also discussed.关键词：Fluorine-18;Brain receptor;PET imaging;Preparation
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