Reversible opening of the blood-brain barrier by mannitol increases brain   uptake of <sup>99m</sup>Tc-TRODAT-1

SUN Wenshan  ZHU Chengmo  LU Zhongwei

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Reversible opening of the blood-brain barrier by mannitol increases brain uptake of ^99mTc-TRODAT-1

更新时间：2021-03-12

- Reversible opening of the blood-brain barrier by mannitol increases brain uptake of ^99mTc-TRODAT-1
- NUCLEAR TECHNIQUES Issue 5, (2001)
- 作者机构：
  
  1. 上海第二医科大学附属瑞金医院,上海,200025
  2. 苏州大学附属第二医院,苏州,215004
- 作者简介：
- 基金信息：
- DOI：
  CLC： R817
- Published：01 May 2001
- 稿件说明：
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[1]孙文善,朱承谟,吕中伟,吴锦昌.血脑屏障可逆性开放增强~(99m)Tc-TRODAT-1脑摄取的初步研究[J].核技术,2001(05):337-340.

SUN Wenshan ZHU Chengmo LU Zhongwei. Reversible opening of the blood-brain barrier by mannitol increases brain uptake of ^99mTc-TRODAT-1[J]. Nuclear techniques, 2001, (5): 337-340.
[1]孙文善,朱承谟,吕中伟,吴锦昌.血脑屏障可逆性开放增强~(99m)Tc-TRODAT-1脑摄取的初步研究[J].核技术,2001(05):337-340. DOI：

SUN Wenshan ZHU Chengmo LU Zhongwei. Reversible opening of the blood-brain barrier by mannitol increases brain uptake of ^99mTc-TRODAT-1[J]. Nuclear techniques, 2001, (5): 337-340. DOI：

摘要

为探索应用血脑屏障可逆性开放是否可应用于增强99mTc -TRODAT - 1脑摄取

把 36只大鼠分为正常组和开放组

分别给予左侧股静脉注射 0 .9%生理盐水和 2 0 %甘露醇 ;再经尾静脉注射 0 .2mL99mTc -TRODAT - 1（ 7.4MBq）

比较两组不同时间99mTc -TRODAT - 1的脑摄取。将SD大鼠分为甘露醇组和甘露醇 +GBR12 90 9组

观察甘露醇开放血脑屏障是否影响99mTc -TRODAT - 1的特异性结合。结果表明

开放组大鼠经注射甘露醇后

全脑和纹状体摄取在 2、30、60min时均比对照组增高

纹状体小脑在 2min时也明显增高 ;甘露醇 +GBR12 90 9组纹状体小脑值显著低于甘露醇组

表明甘露醇注射后并不影响99mTc -TRODAT - 1与DAT的结合特异性。说明血脑屏障的可逆性开放可应用于增加99mTc标转运蛋白显像剂进脑量的研究

以改善图象质量。

Abstract

To determine whether the reversible opening of blood-brain barrier is able to increase the brain uptake of 99m Tc-TRODAT-1; Adult Sprague-Dawley rats were infused with mannitol via femoral vein at rates 0.25mL/kg·s for opening blood-brain barrier

GBR12909 was used to characterize the pharmacological specificity of 99m Tc-TRODAT-1 for dopamine transporters after infusion of mannitol. After infusion of mannitol

the brain uptake of 99m Tc-TRODAT-1 showed a dramatic increase

but no effect on striatum/cerebellum and pharmacological specificity of 99m Tc-TRODAT-1. This study shows that the reversible opening of blood-brain barrier with mannitol may be a useful approach to improve brain uptake of 99m Tc-TRODAT-1 and other 99m Tc-labeled specific receptor imaging agents.

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Reversible opening of the blood-brain barrier by mannitol increases brain uptake of 99mTc-TRODAT-1

DOI：

摘要

Abstract

关键词

Keywords

references

Reversible opening of the blood-brain barrier by mannitol increases brain uptake of ^99mTc-TRODAT-1