Density changes in striatal dopamine transporters and D<sub>2</sub> receptors   in MPTP treated mouse model

SUN Wenshan  1  LIU Zhenguo  1  SHEN Minghua  2  LI Peiyong  1    ZHU Chengmo  1  CHEN Shengdi  1  1

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Density changes in striatal dopamine transporters and D₂ receptors in MPTP treated mouse model

更新时间：2021-03-12

- Density changes in striatal dopamine transporters and D₂ receptors in MPTP treated mouse model
- NUCLEAR TECHNIQUES Issue 5, (2001)
- 作者机构：
  
  1. 上海第二医科大学附属瑞金医院,上海,200025
  2. 复旦大学药学院,上海,200032
- 作者简介：
- 基金信息：
- DOI：
  CLC： R817
- Published：01 May 2001
- 稿件说明：
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[1]孙文善,刘振国,沈鸣华,李培勇,朱承谟,陈生弟.用~(125)I-β-CIT与~(125)I-IBZM体内放射自显影研究MPTP致帕金森病小鼠中枢多巴胺转运蛋白与受体变化[J].核技术,2001(05):413-416.

SUN Wenshan 1 LIU Zhenguo 1 SHEN Minghua 2 LI Peiyong 1 ZHU Chengmo 1 CHEN Shengdi 1 1. Density changes in striatal dopamine transporters and D₂ receptors in MPTP treated mouse model[J]. Nuclear techniques, 2001, (5): 413-416.
[1]孙文善,刘振国,沈鸣华,李培勇,朱承谟,陈生弟.用~(125)I-β-CIT与~(125)I-IBZM体内放射自显影研究MPTP致帕金森病小鼠中枢多巴胺转运蛋白与受体变化[J].核技术,2001(05):413-416. DOI：

SUN Wenshan 1 LIU Zhenguo 1 SHEN Minghua 2 LI Peiyong 1 ZHU Chengmo 1 CHEN Shengdi 1 1. Density changes in striatal dopamine transporters and D₂ receptors in MPTP treated mouse model[J]. Nuclear techniques, 2001, (5): 413-416. DOI：

摘要

应用12 5I- β -CIT和12 5I-IBZM体内放射自显影技术研究了MPTP致帕金森病小鼠中枢多巴胺转运蛋白（DAT）与多巴胺D2 受体（D2 R）变化。结果表明 :对于给予MPTP （ 30mg kg·d）日数分别为 1、3、5、7d的小鼠

用药早期

DAT密度即表现为降低

而D2 R密度在早期未有显著改变。随着日数增加

D2 R密度表现为升高

受体呈超敏状态。提示联合应用DAT与D2 R显像剂同时进行SPECT显像

有利于临床PD病诊断与鉴别诊断以及评估黑质 -纹状体DA神经元的变性程度。

Abstract

To observe the density changes of the dopamine transporters (DAT) and receptors in MPTP treated mouse model. Mice ( n =30) were given i.v. injections of 30mg/kg MPTP for 1

7 days respectively

and in vivo autoradiographic experiments were performed in the striatum using β-CIT for DAT

and IBZM for D 2R. Results showed that a significant decrease of 125 I-β-CIT binding was observed in the early phase

while no dramatic change occurred in 125 I-IBZM binding

but D 2R showed supersensitivity in the later stage. Thus combined imaging of DAT and D 2R may provide a valuable information for clinical and differential diagnosis of PD and assessment of the magnitude of degeneration of nigrastriatum.

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Density changes in striatal dopamine transporters and D2 receptors in MPTP treated mouse model

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摘要

Abstract

关键词

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Density changes in striatal dopamine transporters and D₂ receptors in MPTP treated mouse model