The clinical application of <sup>89</sup>Sr in the treatment of metastatic bone pain

JIN Zhikui  ZHOU Daqing  ZENG Qin  ZHANG Qiang  CHEN Shaoping

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The clinical application of ⁸⁹Sr in the treatment of metastatic bone pain

更新时间：2021-03-12

- The clinical application of ⁸⁹Sr in the treatment of metastatic bone pain
- NUCLEAR TECHNIQUES Issue 5, (2001)
- 作者机构：
  
  江苏省肿瘤医院,南京,210009
- 作者简介：
- 基金信息：
- DOI：
  CLC： R738.1
- Published：01 May 2001
- 稿件说明：
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[1]金稚奎,周大庆,曾琴,张强,陈少萍.~(89)Sr治疗转移性骨肿瘤骨痛的临床应用[J].核技术,2001(05):365-369.

JIN Zhikui ZHOU Daqing ZENG Qin ZHANG Qiang CHEN Shaoping. The clinical application of ⁸⁹Sr in the treatment of metastatic bone pain[J]. Nuclear techniques, 2001, (5): 365-369.
[1]金稚奎,周大庆,曾琴,张强,陈少萍.~(89)Sr治疗转移性骨肿瘤骨痛的临床应用[J].核技术,2001(05):365-369. DOI：

JIN Zhikui ZHOU Daqing ZENG Qin ZHANG Qiang CHEN Shaoping. The clinical application of ⁸⁹Sr in the treatment of metastatic bone pain[J]. Nuclear techniques, 2001, (5): 365-369. DOI：

摘要

用8 9Sr治疗转移性骨癌 80例以评价镇痛疗效

毒副作用和使用剂量。在 17例血像资料完整的病例中

7例剂量为 1.11— 1.4 8MBq kg的白细胞和血小板计数治疗前后未见显著差异

10例剂量为 1.4 8— 2 .2 2MBq kg的血象治疗过程中有轻度改变

低谷时平均下降 14.1%和 2 4 .1%。89Sr治疗后

2 5 80例（ 31.2 5% ）疼痛消失（ 4级） ;34 80例（ 4 2 .5% ）疼痛显著减轻（ 3级） ;13 80例（ 16.2 5% ）疼痛轻度减轻（ 2级） ;8 80例（ 10 .0 % ）疼痛无变甚至加剧（ 1级）。89Sr最佳冶疗剂量范围为 1.11— 1.4 8MBq kg。

Abstract

Clinical application of 80 patients treated with 89 Sr for metastatic bony pain was reported the toxic effet and dosage was also evaluated. Of the 17 cases with complete blood sample examination

7 cases with the dosage of 1.11—1.48MBq/kg showed no changes in leukocyte and platelet count. 10 cases with the dosage of 1.48—2.22MBq/kg showed slight decline 14% and 23% respectively in leukocyte and platelet count. 5—6 weeks after 89 Sr treatment. As to the pain relief 25 cases 31.25% complete pain free (grade 4)

34 (42.5%) are of significant pain decrease (grade 3)

13 (16.25%) are of slight pain decrease (grade 2)

8 (10.0%) are of no change or even pain aggravated (grade 1)

the total efficacy of 89 Sr was 90.0% and the significant efficacy (complete pain free + significant pain relief) was 73.75%. The optimal dose of our study was within the range of 1.11—1.48MBq/kg. Thereby

it was concluded 89 Sr was effective for relief of the metastatic bony pain.

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The clinical application of 89Sr in the treatment of metastatic bone pain

DOI：

摘要

Abstract

关键词

Keywords

references

The clinical application of ⁸⁹Sr in the treatment of metastatic bone pain