Synthesis and tissue distribution in mice of <sup>18</sup>F-FDG

TANG Ganghua  WANG Mingfang  WU Hubing  GAO Xiao  LI Zhi    LUO Lei  HUANG Zuhan

doi:null

您当前的位置：

首页 >

文章列表页 >

Synthesis and tissue distribution in mice of ¹⁸F-FDG

更新时间：2021-03-12

- Synthesis and tissue distribution in mice of ¹⁸F-FDG
- NUCLEAR TECHNIQUES Issue 5, (2001)
- 作者机构：
  
  第一军医大学南方医院,广州,510515
- 作者简介：
- 基金信息：
- DOI：
  CLC： TQ464
- Published：01 May 2001
- 稿件说明：
移动端阅览
[1]唐刚华,王明芳,吴湖炳,高晓,李志,罗磊,黄祖汉.~(18)F-FDG的制备及在小鼠体内分布研究[J].核技术,2001(05):417-420.

TANG Ganghua WANG Mingfang WU Hubing GAO Xiao LI Zhi LUO Lei HUANG Zuhan. Synthesis and tissue distribution in mice of ¹⁸F-FDG[J]. Nuclear techniques, 2001, (5): 417-420.
[1]唐刚华,王明芳,吴湖炳,高晓,李志,罗磊,黄祖汉.~(18)F-FDG的制备及在小鼠体内分布研究[J].核技术,2001(05):417-420. DOI：

TANG Ganghua WANG Mingfang WU Hubing GAO Xiao LI Zhi LUO Lei HUANG Zuhan. Synthesis and tissue distribution in mice of ¹⁸F-FDG[J]. Nuclear techniques, 2001, (5): 417-420. DOI：

摘要

采用PETtrace回旋加速器 -FDG合成系统

通过18O（p

n） 18F核反应和亲核取代反应制备18F -FDG

放化产率约为 54%

放化纯度大于 95%。小鼠体内分布实验表明

18F -FDG在心肌和脑中有较高的摄取率

且放射性持续时间较长

并通过肾脏迅速排出。注入18F -FDG 30min后

放射性在血和各脏器中的分布逐渐达到平衡。制备的18F -FDG适于临床PET研究和诊断

Abstract

Deoxy-2- 18 F-fluoro-D-glucose ( 18 F-FDG) was synthesized via nuclear reaction 18 O(p

n) 18 F and nucleophilic substitution reaction by PET trace Cyclotron-FDG Synthesis System. The corrected radiochemical yield was about 54% and the radiochemical purity was above 95% by HPLC and TLC. The distribution of 18 F-FDG in mice showed that the higher uptake rates of 18 F-FDG in heart and brain were found

the radioactivity reteined in heart and brain for longer time and the radioactivity in kidney was rapidly cleared. The radioactivity in blood and organs dropped very slowly 30min after injection of 18 F-FDG. The synthetic 18 F-FDG allowed for PET study and diagnosis of patients.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Synthesis of Carboxylic ion exchange fiber and its application in Uranium extraction

Preparation of dopamine D2 receptor imaging agent ¹⁸F-Fallypride and biodistribution study in mice

Radiation synthesis and optical absorption property of nano Ag-PVA-H₂O sol

Progress in the synthesis of cyclopentadienyltricarbonyl rhenium complexes and its application in radiopharmaceuticals

Synthesis and fluoro-radiolabelling of dopamine D₂ receptor imaging agent ¹⁸F-FSABZM

Related Author

LEI Yunyi1 LIN Kunhua1 WANG Fushun2 XU Yanli1 BAO Borong1 XU Yinjuan1 1

林昆华

汪福顺

徐艳丽

徐引娟

包伯荣

徐宇平

王颂佩

Related Institution

上海大学环化学院

Department of Chemistry,Shanghai University,Shanghai 200444,China) 2

江苏省原子医学研究所卫生部核医学重点实验室

Jiangsu Institute of Nuclear Medicine,Key Laboratory of Nuclear Medicine,Ministry of Health

郑州大学材料工程学院

AI问答

Address：2019 Jialuo Road, Jiading, Shanghai, China Postal code：201800
Tel：021-39194977 Email：LHB@sinap.ac.cn
Technical support is provided by Beijing Founder electronics co., LTD 沪ICP备05005479号-1 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.
Total Visits：880886 Visits Today：413

⁰

Synthesis and tissue distribution in mice of 18F-FDG

DOI：

摘要

Abstract

关键词

Keywords

references

Synthesis and tissue distribution in mice of ¹⁸F-FDG