最新刊期
      卷 0 ， 期 0 ， 2020
      • LI Xuan ZHAO Minghua WANG Baoliang ZHANG Meng
        Vol. 31, Issue 8, (2008)
        摘要：Based on the understanding of coupler cavity matching in all operation modes and the equivalent circuit method, we found a numerical simulation method by computer simulation. It was used to create a model of one input coupler, one output coupler and two accelerating cells. The results show that this method is feasible for the coupler matching.  
        关键词：Coupler;CST;Numerical simulation;Operating mode   
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        发布时间：2021-03-12
      • ZHOU Sizhong1 QU Weide1,2 DENG Xiaoguo1,2 XIA Shaojian3 JIANG Bo1 YANG Xiaoxu1 1
        Vol. 31, Issue 8, (2008)
        摘要：For the third synchrotron radiation facility, four reasons resulting in diffraction crystal distortion of double-crystal monochromator, and deficiency of traditional water cooling crystal are analyzed, and irregular structure of water cooling crystal is proposed. Slope error of crystal have achieved by numerical simulation analysis of finite element method. The result indicates that slope error of crystal surface in sagital and meridian is 1″and 0.6″.  
        关键词：Double crystal monochromator;Synchrotron radiation;Water cooling irregular crystal;Finite element analysis;Thermal load   
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        发布时间：2021-03-12
      • XIE Honglan HU Wen LUO Hongxin DENG Biao DU Guohao XUE Yanling CHEN Rongchang SHI Shaomeng XIAO Tiqiao
        Vol. 31, Issue 8, (2008)
        摘要：Unlike traditional outside-source holography, X-ray fluorescence holography is carried out with fluorescent atoms in a sample as source light for holographic imaging. With the method, three-dimensional arrangement of atoms into crystals can be observed obviously. However, just like traditional outside-source holography, X-ray fluorescence holography suffers from the inherent twin-image problem, too. With a 27-Fe-atoms cubic lattice as model, we discuss in this paper influence of the photon energy of incident source in removing twin images in reconstructed atomic images by numerical simulation and reconstruction with two-energy X-ray fluorescence holography. The results indicate that incident X-rays of nearer energies have better effect of removing twin images. In the detector of X-ray holography, minimum difference of the two incident energies depends on energy resolution of the monochromator and detector, and for inside source X-ray holography, minimum difference of the two incident energies depends on difference of two neighboring fluorescent energies emitting from the element and energy resolution of detector. The spatial resolution of atomic images increases with the incident energies. This is important for experiments of X-ray fluorescence holography, which is being developed on Shanghai Synchrotron Radiation Facility.  
        关键词：X-ray fluorescence holography;Twin image;Reconstruction algorithm;Synchrotron radiation   
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        发布时间：2021-03-12
      • WANG Danni1,2 WANG Baoyi1 ZHANG Lanzhi1,2 ZHONG Yurong1,3 ZHANG Zhiming1 LI Daowu1 WEI Long1 ZHANG Tianbao1 1
        Vol. 31, Issue 8, (2008)
        摘要：A positron annihilation CDB (coincident Doppler broadening ) spectrometer of high-performance has been developed with modes of external and internal triggers. The external trigger mode, with time resolution of < 7 ns (FWHM) and peak/background ratio of better than 106, is applicable to measurements at high coincident count rate over 200/s. The internal trigger mode has a time resolution of 94 ns and peak/background ratio of >105. It, is not as good as the external trigger mode, but the peak/background ratio can be increased to106 after pileup signals are rejected by an arithmetic code, so as to be applicable to measurements at 100/s or lower coincident count rates. The internal trigger mode is simple and convenient to use, unlike the external mode. In addition to performance determination of the CDB spectrometer, CDB spectra of pure Cu, Ni, W and Al were measured and relativistic kinetic energy formula E2total=p2c2+m2ec4 was validated by observing positron annihilation in flight. The results show that performance of this spectrometer is favorable in time resolution and background restraint. As an application example, chemical surroundings around the intrinsic vacancy-type defects in NiAl alloys at deviations from the stoichiometric compositions were investigated. The results indicate that the spectrometer is highly sensitive to element variations around open-volume defects and has wide application prospect in the field of microstructure investigation of materials.  
        关键词：Positron annihilation;Coincident Doppler broadening;Performance study   
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        发布时间：2021-03-12
      • XU Jianguo ZOU Yubin GUO Zhiyu TANG Guoyou GUO Lian GUO Jimei
        Vol. 31, Issue 8, (2008)
        摘要：Mont-Carlo simulation was performed for shielding CCD chip of an accelerator-based thermal neutron radiography instrument from the γ-rays and neutrons. The simulation results were comparable with experimental data. The current shielding system was evaluated with this method. The dose rate of γ-rays and neutrons in the CCD chip was calculated and the influence of different shielding materials and geometry on γ dose rate and fast neutron flux density in the CCD chip was investigated. The simulation indicates that the current shielding design can satisfy the operation demands of the thermal neutron radiography instrument with thick target 9Be (d, n) reaction.  
        关键词：Accelerator-based neutron source;CCD camera;Shielding;Simulation;Absorbed dose rate   
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        发布时间：2021-03-12
      • MAMAT Mamatrishat 1 ABULIEMU Aierken 1 ZHAO Jingwu2 KADIER Abudoumoming 1 WANG Shiheng1 LIU Shengkang 2 SHI Feiyue2 XIAERDING Puerkaiti 1 1
        Vol. 31, Issue 8, (2008)
        摘要：Paraffin layers under a steel plate were used to simulate oil crust in pipelines by detecting scattered γ-rays in different solid angles from a 60Co source, which irradiated the specimen in quasi-parallel incidence. A linear rela-tionship was obtained between the counting rates of the scattering γ-rays and the paraffin thickness. The best sensitiv-ity of measurement is 1181/mm, with the linearity coefficient of 0.9909.  
        关键词：γ photon counts;Compton scattering;Thickness of oil crust   
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        发布时间：2021-03-12
      • XIAO Dexin WANG Baojian HE Xiaohai LIU Ping ZHAO Jianhua
        Vol. 31, Issue 8, (2008)
        摘要：Nowadays, for its capability in tracking thousands of macro particles, PIC coding has to become an im-portant tool for studying beam physics. In this paper the PIC method for the accelerator’s electron-optics simulation is introduced; 1.2 MW accelerator’s electron-optical-system made in Chinese Academy of Engineering Physics has also been simulated using static and dynamic methods. Results show that as the intensity of the beam flux increases, the radius of the beam firstly decreases and then increases gradually. When the beam flux is around 250 mA, the beam radius reaches a minimum value, and the results of these two methods differentiate with each other by 7%; however, the beam radius of 500 mA beam flux reaches to that of small beam flux, and the results of these two methods differ from each other by 29%.  
        关键词：Electron accelerator;Electron optics;PIC simulation   
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        发布时间：2021-03-12
      • ZHANG Limin ZHANG Xiaodong YOU Wei WANG Wenxiu GE Qin LIU Zhengmin
        Vol. 31, Issue 8, (2008)
        摘要：The effects of O and C ion implantation with different implantation doses on the yellow luminescence (YL) from unintentional doped n-type GaN have been studied by the photoluminescence (PL) spectra. O and C ions were implanted in the GaN samples with different doses from 1.0×1013 to 1.0×1017cm-2. Post-annealing was done in a quartz open-tube furnace under flowing N2 gas for 30 min at 950°C. By comparing with N ion implanted samples, it is assumed that different deep-level centers involving in the YL were produced in GaN after O and C ion implantation. In addition, with a dose of 1017 cm-2, the concentration of deep C centers involving in the YL was enhanced markedly.  
        关键词：GaN;Ion implantation;PL spectra   
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        发布时间：2021-03-12
      • ZHU Jingbo LI Shuzhen CHEN Nan ZHANG Yuan HSIA Yuanfu
        Vol. 31, Issue 8, (2008)
        摘要：A mini-transducer for Mssbauer is described in this paper. The mini-transducer uses SmCo5 magnets instead of AlNiCo5. The mini-transducer is featured by its weight (1360 g) and size (Φ67.5 mm×113.5 mm). The ratio between error signal value and the velocity signal(peak-to-peak) is lower than 0.4%. At room temperature, the average Mssbauer line width of the inner lines of a 25 μm α-Fe foil is less than 0.23 mm/s. The transducer can be used to measure Mssbauer spectrum with long-time stability.  
        关键词：Miniaturized Mssbauer spectrometer;Transducer   
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        发布时间：2021-03-12
      • LONG Yindong1,2 QIAO Weimin1 ZHAO Long1,2 JING Lan1 1
        Vol. 31, Issue 8, (2008)
        摘要：The power-control system of synchronized accelerator must be a high definition and real time system. In this paper we introduced a platform for parameter analysis and realization. As a necessary part of the digital adjustor, it is achieved by the method of state-space equation based on the Cyclone II for improving performance of the accelerator power-control system. With the platform, the object control in a precision range of up to 1064 can be realized, depending on the optimum arithmetic and the MATLAB functions. In addition, considering the actual environment, the parameters the actual demands can be better met by choosing the parameters, providing a necessary support to achieve the higher definition and better real time adjustor.  
        关键词：Apices;MATLAB;Digital adjuster;State-space equation   
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        发布时间：2021-03-12
      • XIE Bo YANG Tongzai HU Rui
        Vol. 31, Issue 8, (2008)
        摘要：Sn-Li alloy is considered as a potential liquid breeding materials for fusion reactor. For an effective design of the experimental loop for liquid breeder in-pile production tritium and liquid blanket neutronic, in this paper, a mathematical model of gas-eutectic interface and a time-dependent multi-group diffusion equation and eigenfunction expansion method has been introduced and the tritium breeding behavior of liquid Li25Sn75 alloy has been imitated. Calculation results have shown that cross section of Sn-nat (n, 2n) is 1.5 barns at 14 MeV, and the tritium breeding with time in 7Li and 6Li is showing no difference with LiPb alloy and Li2O, and the effects on TBR from Li25Sn75 alloy is sensitive and TBR increases with increasing sizes and concentration of 6Li.  
        关键词：Sn-Li alloy;TBR;Neutron;Fusion reactor   
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        发布时间：2021-03-12
      • LIU Gang CAI Xiaowu HAN Zhengsheng LU Jiang WANG Lixin XIA Yang
        Vol. 31, Issue 8, (2008)
        摘要：Total dose irradiation effects on a VDMOS developed at Institute of Microelectronics, CAS were investigated, particularly the electric parameter changes under different bias conditions. It was found that the breakdown voltage degradation by the irradiation depended mainly on the drain bias, whereas the threshold voltage degradation depended mainly on the gate bias. Thus, an innovative and effective method to domestic VDMOS total dose ionization characterization is that threshold voltage radiation hardening characterization should be tested on gate bias condition, and the breakdown voltage radiation hardening characterization, be tested on the drain bias.  
        关键词：VDMOS;Total ionization dose;Ionization;Power MOSFET   
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        发布时间：2021-03-12
      • ZHANG Yong1 XU Jiehua1 CHEN Weizhen1 LU Hanping2 LIANG Changsheng3 ZOU Juntao4 XIE Yao4 LIU Changzheng2 1
        Vol. 31, Issue 8, (2008)
        摘要：To evaluate the effect of 188Re-7E11C5.3 radioimmunotherapy on human prostate cancer, 32 nude mice bearing LNCaP xenograft tumor were randomized into four groups, i.e. the 188Re-7E11C5.3, the 188Re-mIgG and the 188ReO4- groups, plus the control group. After 5.55 MBq single dose intravenous injection through the tail, changes in body weight and the tumor volume were monitored for four consecutive weeks. The serum PSA levels were detected. The tumors were weighed and inhibitory rate of the tumor growth was calculated. The results showed that the tumor weight and serum PSA level of the mice were significantly lower in 188Re-7E11C5.3 group than those in the control group (P<0.01). The inhibitory rate of tumor growth was 60.7% in the 188Re-7E11C5.3 group. There was no significant difference of tumor weight and serum PSA level among 188Re-mIgG, 188ReO4- and control groups(P>0.05). In conclusion, 188Re-7E11C5.3 can effectively inhibit the growth of xenografted human prostate cancer and may be a suitable radiopharmaceutical for the treatment of prostate cancer.  
        关键词：Prostatic carcinoma;Antibody;Monoclonal;Rhenium-188;Radioimmunotherapy   
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        发布时间：2021-03-12
      • ZHANG Jianghong1 HAO Furong2 JIN Yizun1 1
        Vol. 31, Issue 8, (2008)
        摘要：The object of this work is to evaluate radiosensitization of MMC and its analogue 5-(aziridin-1-yl)-3- hydroxymethyl-1-methylindole-4,7-dione(629) and how transfection of constitutive androstane receptor (CAR) affect their biological effects. The expressions of CAR mRNA and CYP2B6 mRNA in HepG2 cells and g2car cells were detected by RT-PCR. The radiosensitization of MMC and 629 in vitro were evaluated in HepG2 cells and g2car cells by colony formation under anaerobic and aerobic condition. The effect of 629 on cell cycle and apoptosis of HepG2 cells and g2car cells were assayed by flow cytometry. It was found that plasmid mCAR1/pCR3 was transfected into g2car cells successfully and target CYP2B6 was transactivated by CAR. To compare with aerobic and anaerobic, the radiosensitization of MMC and 629 to HepG2 cells and g2car cells had significantly enhanced, the radiosensitization of 629 was stronger than its parent compound—MMC under aerobic and anaerobic condition, and transfect CAR gene could improve the radiosensitization of MMC and 629. Furthermore, CYP2B6 is one master enzyme for the metabolism of MMC and 629. Transfection of CAR can increase expression of CYP2B6 mRNA in HepG2 cells, and can affect radiosensitization of MMC and 629.  
        关键词：629;MMC;Hypoxia;Radiosensitization;Consititutive androstane receptor   
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        发布时间：2021-03-12
      • XU Dongsheng1,2 LIU Fenju1 SUN Zhiqiang1 YANG Xueqin1 CHEN Qiu1 ZHOU Weifang1 CHEN Ling1 1
        Vol. 31, Issue 8, (2008)
        摘要：In this paper, effect of fast-neutron and X-rays on the expression of P53 and CyclinB1 in small intestinal tissues of mice were investigated. The mice were randomly grouped and sacrificed 6 h after irradiation. Western blot assay was applied to detect the p53 and CyclinB1 expressions, and flow cytometry was used to monitor changes in the small intestinal cell cycle. The results showed that the expression levels of p53 increased with irradiation dose. The expression levels of CyclinB1 increased with the dose at first, but decreased when the dose exceeded 0.28 Gy. The results from the flow cytometry showed that the amount of cells in G2/M phase increased with the dose in both occasions. It was concluded that the low doses of fast-neutron and X-rays can make the expression levels of p53 and CyclinB1 increase, but the expression levels of CyclinB1 decreased and the G2 arrest occurred with increased doses.  
        关键词：Fast-neutron;X-ray;p53;CyclinB1;G2 / M phase   
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        发布时间：2021-03-12
      • WAN Xiaojuan1 WANG Jia2 ZHENG Jianfei2 DOU Daying1 XU Gang1 JIAO Zheng1 WU Minghong2 DING Guoji2 1
        Vol. 31, Issue 8, (2008)
        摘要：The fast development and application of food irradiation technology signify the necessity and urgency to research on effective detection method for irradiated food. In this paper, we report a preliminary study in this area with dried chili powder, peanuts and strawberry seeds. The food samples were irradiated to 0.5, 1.0, 3.0, 5.0 and 10.0 kGy by 60Co gamma rays. The relation between ESR intensity and irradiation dose, and correlation R2, were studied. The results showed that the ESR signal intensity is positively related with the dose. ESR intensity of the strawberry increased the slowest with the dose, and the chili powder had the most accurate calculation. Accurate dose-effect curves, however, require repeating tests and further studies are needed to verify the ESR results.  
        关键词：Electron spin resonance;Irradiation dose;Free radical;Dose-effect curve   
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        发布时间：2021-03-12
      • ZHOU Guilou1,2 JIANG Mengjun2 ZHANG Rongjun2 CAI Gangming2 ZHOU Yaoyuan2 ZHANG Bo2 GU Xiaobo2 YE Wanzhong2 JIN Jian1 CAO Guoxian2 BAO Jiandong2 ZHOU Xingqin2 1
        Vol. 31, Issue 8, (2008)
        摘要：The work is to evaluate the liver-targeting ability of 99Tcm-GHSA-IFNα2b. 99Tcm-GHSA-IFNα2b was prepared by the reduction of Na99TcmO4 with SnCl2. Effects of the SnCl2 or GHSA-IFNα2b amount and pH value on the labeling yield of 99Tcm-GHSA-IFNα2b were investigated. The biodistribution was studied with ICR mice. 0.2 mL(0.286 MBq) 99Tcm-GHSA-IFNα2b solution containing 2 μg GHSA-IFNα2b was iv injected to each animal through the tail. The mice were decapitated at 5, 10, 15, 30, 60 and 120 min. The organs of interest were excised, weighed, and counted. The ID%/organ and ID%/g were calculated. Liver scan of 99Tcm-GHSA-IFNα2b was performed on a rat . The results showed that labeling yield of 99Tcm-GHSA-IFNα2b could be over 90% under the following labeling conditions: pH 3.0 ~ 4.5, over 0.3 mg of GHSA-IFNα2b, 3 μg~60 μg of SnCl2, and 30 min labeling at 37°C. Biodistribution in mice showed a peak of liver uptake of 99Tcm-GHSA-IFNα2b in 10 min after injection, being excreted mainly via the biliary system and gastrointestinal tract. Clear liver images were obtained in 15~30 min after injection. It can be concluded that GHSA-IFNα2b is a promising interferon with good liver-targeting ability, and 99Tcm-GHSA-IFNα2b is a potential hepatic receptor imaging agent.  
        关键词：GHSA-IFNα2b;Technetium-99m;Hepatic receptor imaging;Biodistribution   
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        发布时间：2021-03-12
      • YANG Min1 WANG Guangji2 XU Yuping1 PAN Donghui1 WANG Songpei1 LI Xiaomin1 TANG Jie1 LUO Shineng1 1
        Vol. 31, Issue 8, (2008)
        摘要：In this work, preparation of 131I-labeled 23-hydroxybetulinic acid (131I-23-HBA) and its pharmacokinetics in mice were studied. 23-HBA was labeled with 131I using the hydrogen peroxide method. Purity and stability of the 131I-23-HBA were evaluated by silicon TLC, in which the substratum of Vdichoromethane: Vmethanol =9:1 was used as the developing agent. The dynamic distribution in ICR mice and liver cancer HepA tumor-bearing mice were studied. The results showed that the labeling yield of 131I-23-HBA was 98% and the radiochemical purities were 98.5%, 97.3%, and 95.8% after 1, 4 and 8 days, respectively. In ICR mice, the blood clearance was quick and the profile of the blood concentration-time was fitted with two compartment model. In tumor-bearing mice 0.5 h after intravenous injection, the liver uptake was the highest (9.14% ID·g-1). The radioisotope was concentrated in kidney, blood, spleen, intestine, lung and tumor, too. The brain uptake was the lowest as 0.28% ID/g at pi. 0.5 h. The tumor-to-muscle ratio was over 3. The labeling yield and purity of 131I-23-HBA are high and 131I-23-HBA is stable. The tumor uptake of 131I-23-HBA is higher than 23-HBA. 131I-23-HBA is a potent cancer treatment drug.  
        关键词：23-hydroxybetulinic acid;131I;Biodistribution;Tumor   
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        发布时间：2021-03-12
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