<sup>188</sup>Re-7E11C5.3 radioimmunotherapy on human prostate cancer xenograft in nude mice

ZHANG Yong1 XU Jiehua1 CHEN Weizhen1 LU Hanping2 LIANG Changsheng3 ZOU Juntao4 XIE Yao4 LIU Changzheng2 1

doi:null

您当前的位置：

首页 >

文章列表页 >

¹⁸⁸Re-7E11C5.3 radioimmunotherapy on human prostate cancer xenograft in nude mice

更新时间：2021-03-12

- ¹⁸⁸Re-7E11C5.3 radioimmunotherapy on human prostate cancer xenograft in nude mice
- NUCLEAR TECHNIQUES Vol. 31, Issue 8, (2008)
- 作者机构：
  
  1. 中山大学附属第三医院核医学科
  2. 中山大学基础医学院实验核医学教研室
  3. 中山大学基础医学实验教学中心
  4. 中山大学基础医学院人体解剖学教研室
- 作者简介：
- 基金信息：
  
  广东省科技计划项目(2003B30103,2007A060305011)资助
- DOI：
  CLC： R737.25
- Published：01 August 2008
- 稿件说明：
移动端阅览
[1]张勇,许杰华,陈维真,卢汉平,梁昌盛,邹俊涛,谢瑶,刘长征.~(188)Re-7E11C5.3在前列腺癌裸鼠模型中的放射免疫治疗研究[J].核技术,2008,31(08):616-618.

ZHANG Yong1 XU Jiehua1 CHEN Weizhen1 LU Hanping2 LIANG Changsheng3 ZOU Juntao4 XIE Yao4 LIU Changzheng2 1. ¹⁸⁸Re-7E11C5.3 radioimmunotherapy on human prostate cancer xenograft in nude mice[J]. Nuclear techniques, 2008, 31(8): 616-618.
[1]张勇,许杰华,陈维真,卢汉平,梁昌盛,邹俊涛,谢瑶,刘长征.~(188)Re-7E11C5.3在前列腺癌裸鼠模型中的放射免疫治疗研究[J].核技术,2008,31(08):616-618. DOI：

ZHANG Yong1 XU Jiehua1 CHEN Weizhen1 LU Hanping2 LIANG Changsheng3 ZOU Juntao4 XIE Yao4 LIU Changzheng2 1. ¹⁸⁸Re-7E11C5.3 radioimmunotherapy on human prostate cancer xenograft in nude mice[J]. Nuclear techniques, 2008, 31(8): 616-618. DOI：

摘要

为探讨188Re标记前列腺特异膜抗原单克隆抗体7E11C5.3放射免疫治疗前列腺癌裸鼠移植瘤的效果

将32只荷LNCaP移植瘤裸鼠随机分成4组:188Re-7E11C5.3组、188Re-mIgG组、188ReO4-组和对照组

采用5.55MBq单剂量尾静脉注射给药

连续4周观察裸鼠体重和肿瘤体积变化。实验结束后

检测裸鼠血清PSA水平

测定移植瘤重量

计算抑瘤率。结果显示

188Re-7E11C5.3组的瘤体重量和动物血清PSA水平均小于对照组（P<0.01）

抑瘤率为60.7%。188Re-mIgG组和188ReO4-组的瘤体重量和裸鼠血清PSA水平与对照组相比差异均无统计学意义（P>0.05）。结果表明

188Re-7E11C5.3能有效抑制前列腺癌裸鼠移植瘤的生长

具有较好的抗前列腺癌应用前景。

Abstract

To evaluate the effect of 188Re-7E11C5.3 radioimmunotherapy on human prostate cancer

32 nude mice bearing LNCaP xenograft tumor were randomized into four groups

i.e. the 188Re-7E11C5.3

the 188Re-mIgG and the 188ReO4- groups

plus the control group. After 5.55 MBq single dose intravenous injection through the tail

changes in body weight and the tumor volume were monitored for four consecutive weeks. The serum PSA levels were detected. The tumors were weighed and inhibitory rate of the tumor growth was calculated. The results showed that the tumor weight and serum PSA level of the mice were significantly lower in 188Re-7E11C5.3 group than those in the control group (P<0.01). The inhibitory rate of tumor growth was 60.7% in the 188Re-7E11C5.3 group. There was no significant difference of tumor weight and serum PSA level among 188Re-mIgG

188ReO4- and control groups(P>0.05). In conclusion

188Re-7E11C5.3 can effectively inhibit the growth of xenografted human prostate cancer and may be a suitable radiopharmaceutical for the treatment of prostate cancer.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Experimental study of ¹⁸⁸Re-BAC₅ radioimmunotherapy on nasopharyngeal carcinoma

A novel study of abumin human serum radiolabeled with (188)~Re

¹⁸⁸Re labeling of prostate cancer monoclonal antibody and its biodistribution in tumor-bearing nude mice

Research of novel bifunctional chelating agents for the ¹⁸⁸Re-tricarbonyl complexes labeling

Reduction-mediated technetium-99m labeling of antibodies -evaluation of various reducing agents

Related Author

刘长征

梁昌盛

樊卫

WANG Guohui LIU Changzheng LIANG Changsheng

尹端沚

于俊峰

汪勇先

XIA Jiaoyun1 WANG Yongxian2 YU Junfeng2 YIN Duanzhi2 1

Related Institution

中山大学肿瘤防治中心核医学科

Department of Experimental Nuclear Medicine,Sun Yat-Sen University, Guangzhou 510080) FAN Wei

放射性药物研究中心

中国科学院上海应用物理研究所

AI问答

Address：2019 Jialuo Road, Jiading, Shanghai, China Postal code：201800
Tel：021-39194977 Email：LHB@sinap.ac.cn
Technical support is provided by Beijing Founder electronics co., LTD 沪ICP备05005479号-1 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.
Total Visits：881163 Visits Today：690

⁰

188Re-7E11C5.3 radioimmunotherapy on human prostate cancer xenograft in nude mice

DOI：

摘要

Abstract

关键词

Keywords

references

¹⁸⁸Re-7E11C5.3 radioimmunotherapy on human prostate cancer xenograft in nude mice