最新刊期
      卷 0 ， 期 0 ， 2020
      • CHEN Man LI Ge HE Duohui WANG Keyi SHEN Qifei
        Issue 11, (2003)
        摘要：The principle and construction of the magnetic gap control system of the transverse optical klystron for the storage ring free electron laser in the NSRL is described in this paper. Hardware, software flowchart and trouble shooting process are given for reliable engineering implementation of the system. The control system based on PC can easily adjust the magnetic gaps of the TOK modulator, dispersion section and radiator separately or simultaneously with 0.01mm gap resolution. The storage ring vacuum chamber is free of destruction by a multi-protection system. Gap resolution can be enhanced one order of magnitude or more with the direct drive system, as suggested in the paper.  
        关键词：Storage ring free electron laser;Optical klystron;Magnetic gap control system   
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        发布时间：2021-03-12
      • YIN Shilong BIAN Qing ZHANG Jing XIE Guozhi WANG Hongbing WEI Shiqiang
        Issue 11, (2003)
        摘要：The structures and magnetic properties of the as-spun and annealed Nd9Fe85-xMnxB6 (x=0, 0.5, 1.0) nano-composite magnetic materials were investigated by XRD, XAFS and vibrating sample magnetometer (VSM). The XRD and XAFS results indicated that the structures of the as-spun Nd-Fe-B nano-composites were largely correlated by the addition of element Mn. With increasing the amount of element Mn, the long-range order of both soft magnetic phase a-Fe and hard magnetic phase Nd2Fe14B largely increased. After annealed at the optimal temperature of 973 K for 5 min, the results implied that the long-range and local structures of the Nd9Fe85B6 were almost the same as those of Nd9Fe84 5Mn0.5B6 and Nd9Fe84Mn1B6. However, the VSM results showed that the coercivity was obviously enhanced from 339 to 398 kA/m for the annealed Nd9Fe85-xMnxB6 nano-composites with the x from 0 to 1. These results were supposed to arise from the exchange coupling between the Nd2Fe14B and α-Fe grains induced by the addition of element Mn.  
        关键词：Nano-composite magnetic materials;X-ray absorption fine structure;X-ray diffraction;Exchange coupling effect   
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        发布时间：2021-03-12
      • CHEN Shaohua XING Pifeng CHEN Wenmei LlU Jun
        Issue 11, (2003)
        摘要：In order to prepare low cost, high hydrogen permeability, long runtime and high stress H-permselective membranes, the refractory metal zirconium(Zr) was selected as the membranes substrate. At the vacuum of 3.0×10-7Pa, ion bombardment eroding was used to remove the oxide film of zirconium on the surface. It is found that a small amount of oxide film still existed on the film. At the vacuum of 6.6× 10-6Pa, an about 400nm thick Pd film was plated on both surfaces of the zirconium disk(050mmx0.23mm) by the method of ion sputtering plating. The surfaces of the zirconium and the composite membranes were analyzed by XRD and XPS. Through hydrogen permeating tests, it showed that the H-permeability of this composite membrane was 9.917×10-8mol/m·s·Pa1/2 (at 623K, up-pressure 0.2MPa, down pressure 0. 1MPa), 6.8 times as high as that of commercial Pd-Ag membranes in the same state. It is found that this Pd-Zr H-permselective composite membrane can be vastly applicable for the purification of nuclear and fusion fuel and the distillation of tritium from breeder reactors.  
        关键词：H-permselective membranes;Hydrogen purification;Pd-Zr alloy   
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        发布时间：2021-03-12
      • ZENG Yuxin CHENG Guoan WANG Shuifeng XIAO Zhisong
        Issue 11, (2003)
        摘要：Neodymium ions were implanted into silicon epitaxial layer with MEWA ion source in low ion flux. Nd silicides with good properties were synthesized after rapid thermal annealing (RTA). Comprehensive analyses including scanning electron microscope (SEM), reflection high energy electron diffraction (RHEED) and X-ray diffraction (XRD) show that the Nd silicides formed by MEVVA ion implantation have good crystalline quality. The XRD result indicates a phase transition from Nd5Si4 to NdSi, and the transition process is also discussed.  
        关键词：Ion implantation;Nd silicide;Phase   
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        发布时间：2021-03-12
      • WUYu YU Zengliang HU Suhua CHEN Bin LUun ZHANG Shuqing CHEN Lianyun WANG Xufei WANG Shaohu
        Issue 11, (2003)
        摘要：The factors influencing the beam quality in the device of single-particle microbeam were overall analyzed and a new method for optimizing this quality was put forward in this paper. This optimization method is to reduce the diameter of the collimator exit in the single-particle microbeam facility by a device including the units for the precise measurement of beam emittance and the automatic adjustment of beam focus.  
        关键词：Single-particle microbeam;Beam quality optimization;Focusing;Automatic adjustment   
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        发布时间：2021-03-12
      • WANG Chongjie ZHANG Ailian
        Issue 11, (2003)
        摘要：This paper introduces a method which can eliminate the interference of 232Th to 40K directly in the y energy spectra by using a standard mixed source of 232Th and 40K. The comparison between this method and the efficiency curve method indicates that the relative deviation is less than 3% for 232Th and less than 1% for 40K. The advantage of this method is that the detecting efficiency of 40K can be determined, and the interference of 232Th to 40K can be eliminated without knowing the efficiency calibration curve of the detecting system.  
        关键词：γ energy spectrum analysis;Efficiency calibration;Curve fitting;Voluminal standard radioactive source;Interference between nuclei   
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        发布时间：2021-03-12
      • Erkin YUXuefeng GUO Qi YANRongliang LUWu ZHANG Guoqiang REN Diyuan
        Issue 11, (2003)
        摘要：The effects of total dose radiation on the time characteristic of high-speed CMOS circuits in different radiation bias have been studied and compared with the related DC parameters . The results indicate that there are intense interrelations between the time characteristic and the DC parameters. It is also shown that the different radiation bias causes obviously different irradiation degeneration in the time characteristic of high-speed CMOS circuits.  
        关键词：Time characteristic;Total dose radiation;Radiation bias   
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        发布时间：2021-03-12
      • GU Zhaoxiang JIANG Maosong
        Issue 11, (2003)
        摘要：Nuclear medicine imaging is becoming increasingly important in radiation oncology, not only for tumor staging, but also for treatment planning and follow-up. Positron emission tomography (PET) and single photon emission tomography (SPECT) imaging play a major role in the definition of tumor extent and staging of patients with cancer for three-dimensional and intensity modulated radiation therapy. Since the metabolic change of a tumor tissue usually precedes its morphological changes, it is possible to use these functional techniques to identify tumor tissue before it becomes visible in morphological images. 18F-FDG PET has the best sensitivity, specificity and accuracy in detecting tumor recurrence. In addition, the applications of nuclear medicine imaging for the patients with brain tumors, nasopharyngeal carcinoma, lung cancer, etc., in the conformal radiotherapy are also reviewed.  
        关键词：Radionuclide imaging;Three-dimensional conformal radiotherapy;PET   
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        发布时间：2021-03-12
      • HAO Bin QIAN Jun GAO Xiujian SHEN Minghua MENG Laping ZHU Jianhua
        Issue 11, (2003)
        摘要：99Tcm-labeled dopamine D2 receptor imaging agent 99Tcm-mEBZM was prepared and the biological evaluation was studied. ECD( L,L-ethyl cysteinate dimer) was conjugated with the benzamide derivative, which has high affinity with dopamine D2 receptor, to yield 99Tcm-mEBZM. The biodistribution of 99Tcm-mEBZM in rats and mice was studied. The results showed that 99Tcm-mEBZM has higher stability in vitro and higher lipophilicity. The brain uptake of 99Tcm-mEBZM in mice is high(2.97%ID·g-1 at 2 min), and the ratios of striatum /cerebellum both in rats and in mice were >1.55.  
        关键词：Dopamine D2 receptor;Receptor imaging;Radiopharmaceuticals;99Tcm   
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        发布时间：2021-03-12
      • WANG Xuesong HUYaer XIAZongqin
        Issue 11, (2003)
        摘要：After the treatment of estradiol, ZDYIOI or DMSO (solvent) to cultured CHOm2 cells for a certain peirod, M-receptor density was determined by 3H-NMS binding assay. Parallel observations were carried out with or without the addition of ICI-182780. The Results show that the density of M receptor in cells treated with estradiol or DMSO control were 123.7±23.9 and 89.6±22.9fmol/mg protein, and these values dropped down to 84.8±19.8 and 66.9±22.5fmol/mg with the presence of ICI-182780. The density of M receptor in cells treated by ZDYIOI or DMSO control were 147.3±36.9 and 95.9±24.0fmol/mg, and dropped to 120.8±40.4 and 77.0±22.3fmol/mg protein with the presence of ICI-182780. ICI-182780 caused a much greater decrease of M receptor density in estradiol treated cells than DMSO control cells indicating that estradioi increased the M receptors through action on estradiol receptor. The magnitude of decrease of M receptor density induced by ICI-182780 in ZDYIOI treated group was similar to that in DMSO controls, indicating that the increase of M receptor density induced by ZDY101 could not be inhibited by ICI-182780 and hence had a mechanism different from estradiol.  
        关键词：M-receptor;AD (Alzheimer’s disease);ZDY101;Zhimu;Estradiol;ICI-182780   
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        发布时间：2021-03-12
      • YANG Zhi HUXiaoqian LI Erqiu
        Issue 11, (2003)
        摘要：The aim of this work is to study bio-distribution and tumor absorption of anti breast cancer monoclonal antibody 6C6 and its chimeric antibody 6C6-CHI. The modified Schwartz method was employed to label 6C6 and 6C6CHI with 99Tcm. The labeled antibody was injected to mouse via tail vein and the blood clearance and whole body clearance were observed. Nude mice bearing breast cancer MCF7 cells were injected with 99Tcm-Iabeled antibodiy and the bio-distribution was studied and imaged with γ-ray camera. The yield of the two labeled antibodies was more than 90% and their immunoactivities were more than 80%. The whole body eliminated half-time of 99Tcm-6C6 was 4.1h, and the half-times in blood were rα=0.55h and rβ=12.42h respectively. The whole body half-time of 99Tcm-6C6CHI was 4.28h and the half-times in blood were Tα=0.98h and Tβ=12.42h respectively. The bio-distribution of nude mice bearing breast cancer MCF7 cells was as follows: the ID%/g of tumor and blood was (7.42±0.85) and (5.67±1.44) respectively at 23h after injection of 99Tcm-6C6. The T/NT (tumor to non tumor) ratios were all more than 1.0 except kidney and the ID%/g of tumor and blood was (4.23?.64) and (6.97?.23) respectively at 23h after injection of 99Tcm-6C6CHI. The T/NT (tumor to non tumor) ratios were all more than 1.0 except blood and kidney. The y imaging results showed that the tumor was imaged clearly at 24h after injection of radiolabled antibodies and the other organs did not concentrate the antibodies except kidney. Anti-breast cancer monoclonal antibody 6C6 can be well located in tumor. Although ID%/g of tumor of the chimeric antibody 6C6CHI was slightly lower than that of 6C6 antibody, and ID%/g of blood was higher than that of 6C6, the tumor imaging of 6C6-CHI was also clear.  
        关键词：99Tcm;Labeling;Breast cancer;Monoclonal antibody;Chimeric antibody   
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        发布时间：2021-03-12
      • GUOWanhua ZHANG Jiange JIANG Xufeng ZHANG Liying LUZhongwei LI Peiyong ZHU Chengnio PAN Jiapu
        Issue 11, (2003)
        摘要：Using self-designed automatic extraction software of brain functional area, the grey scale distribution of 18F-FDG imaging and the relationship between the 18F-FDG accumulation of brain anatomic function area and the 18F-FDG injected dose, the level of glucose, the age, etc., were studied. According to the Talairach coordinate system, after rotation, drift and plastic deformation, the 18F-FDG PET imaging was registered into the Talairach coordinate atlas, and then the average gray value scale ratios between individual brain anatomic functional area and whole brain area was calculated. Further more the statistics of the relationship between the I8F-FDG accumulation of every brain anatomic function area and the I8F-FDG injected dose, the level of glucose and the age were tested by using multiple stepwise regression model. After images’ registration, smoothing and extraction, main cerebral cortex of the 18F-FDG PET brain imaging can be successfully localized and extracted, such as frontal lobe, parietal lobe, occipital lobe, temporal lobe, cerebellum, brain ventricle, thalamus and hippocampus. The average ratios to the inner reference of every brain anatomic functional area were 1.01 ± 0.15. By multiple stepwise regresion with the exception of thalamus and hippocampus, the grey scale of all the brain functional area was negatively correlated to the ages, but with no correlation to blood sugar and dose in all areas. To the I8F-FDG PET imaging, the brain functional area extraction program could automatically delineate most of the cerebral cortical area, and also successfully reflect the brain blood and metabolic study, but extraction of the more detailed area needs further investigation.  
        关键词：Brain;Talairach coordinate atlas;Computer assistant;Region of interest;Positron emission tomography;18F-fluorodeoxyglucose   
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        发布时间：2021-03-12
      • CHEN Zhengping ZHOU Xiang DING Shiyu LIN Yansong TANG Jun WANG Feng WUChunying JI Shuren LU Chunxiong FANG Ping
        Issue 11, (2003)
        摘要：The 13I-FP-β-CIT (2β-carbomethoxy-3β-(4-iodophenyl)tropane) was prepared by ourselves. Its partition coefficients were determined. Kinetics of blood clearance in rabbits, biodistribution in rats brains, toxicity test in mice as well as autoradiography in rat’s brain, SPECT imaging in normal monkey’s brain were studied. The partition coefficients were 15 and 28 at pH 7.0 and 7.4 respectively. The brain uptake in rats was rapid (0.78, 0.59 %ID/organ at 2 min, 2 h after injection respectively), the ratios of striatum/cerebellum, striatum /frontal cortex and striatum / hippocampus were 5.2,2.2 and 3.1 at 1 h in rat’s brain. The uptake in striatum could be blocked by p-CFT, suggesting that 131I-FP-β-ClT binds to DAT specifically. The compound was rapidly cleared from rabbits’ blood, taking only 2 min to reduce to half of the original concentration. The ratio of striatum/occipital cortex is 2.7 in autoradiography of rat’s brain. l31l-FP-β-CIT concentrated in striatum in SPECT imaging in normal monkey. The ratio of striatum /cerebellum and striatum /occipital cortex were 5.4 and 6.0 respectively at 2 h. The test of toxicity showed that the dose received by mice was 750 times by human, proving the agent was safe. These results suggest that the compound is a good SPECT imaging agent for DAT.  
        关键词：Parkinson’s Disease;Imaging agents;Dopamine transporter;131I- FP-β-CIT;Biodistribution   
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        发布时间：2021-03-12
      • DUAN Xinhong LUGongxu WANG Xuebin
        Issue 11, (2003)
        摘要：A novel compond, N-(o-methylthiophenyl)-β-mercaptoacetamide (MTPMA),as a tridentate ligand,was synthesized and characterized by IR, 1HNMR, MS(FAB+) and elemental analysis. Two 99Tcm mixed-ligand complexes of 99Tcm (L3,L1a) and 99Tcm (L3,L1b) were produced by ligand exchange reaction. At the same time, the optimized conditions for labelling were obtained. At these conditions, the radiochemical purity of both complexes was better than 90% and they were stable over 6 h at room temperature. Biodistribution study showed that both complexes can penetrate the blood-brain barrier and exhibit retention in mice’s brain .  
        关键词：Mixed ligand complex;Biodistribution;Blood-brain barrier   
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        发布时间：2021-03-12
      • YU Yongli ZHURuisen LU Hankui
        Issue 11, (2003)
        摘要：5 cases of liver metastases of differentiated thyroid cancer (DTC) were given follow-up after 131I therapy. The results were evaluated with clinical appearence, blood examination, radionuclide imaging and survival analysis. The results showed that (1) all cases had survived for 2-9 years in follow-up period; (2) liver metastastic lesion was disappeared after taking 44.77 GBq 131I, as demonstrated by 131I scan and ultrasonic imaging; (3) the sequences and doses of 131I for normal ablation were significantly decreased with total thyroidectomy than with partial-thyroidectomy(P<0.05); (4) the sequences and doses of 131I for normal ablation were significantly decreased with 3.7 GBq initial 131I doses than with <3.7GBq (PO.01). The treatment of 131I with liver metastases from DTC may improve clinical symptoms, raise life quality, reduce lesion size, and prolong life survival.  
        关键词：Thyroid neoplasms;Iodine isotopes;Radiotherapy;Liver neoplasms   
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        发布时间：2021-03-12
      • LI Linfa ZHUYangjun SHENWenhua ZHAO Kui WEN Shifeng LUO Xuguang CHENG Weihe
        Issue 11, (2003)
        摘要：To evaluate the clinical usefulness of 18F-FDG coincidence imaging in detecting tumors and metastases, 87 patients with suspected malignant or recurrent tumors were studied. 259-298MBq I8F-FDG was injected, then 40 -60 min after injection the patients underwent I8F-FDG coincidence imaging using GE HAWKEYE Coincidence SPECT in supine position. After reconstruction using iterative algorithm,we obtained the transaxial,coronal and sagittal sections with X-ray attenuation correction. The images were interpreted visually, and also analyzed with operative, histological, CT/MRI and follow-up studies. There were 61 positives, including 5 false-positives and 56 true-positives; 26 negatives, including 2 false-negatives and 24 true-negatives in altogether 87 patients. 136 lesions were detected by 18F-FDG coincidence imaging,including 41 lymph node and remote metastases. In all patients with suspected malignant tumors, the sensitivity, specificity, positive predictive values, negative predictive values and accuracy of 18FHFDG coincidence imaging were 96.6% (56/58), 82.8% (24/29), 91.8% (56/61), 92.8% (24/26) and 92.0% (80/87) respectively. 18F-FDG coincidence imaging had high sensitivity and specificity in tumor diagnosis, and had unique advantages in ascertaining tumor’s nature and in detecting recurrence or metastases, and it was also a valuable diagnostic and investigative method for patients with cancer.  
        关键词：18F-FDG;Coincidence SPECT;Tumors   
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        发布时间：2021-03-12
      • DING Weimin CHEN Yingmao TIAN Jiahe ZHANG Jinming FENG Huiru YAO Shulin
        Issue 11, (2003)
        摘要：We have calculated the absorbed dose in tissue-equivalent medium(polyethylene) from radioactive filter paper with beta dose point kernels, and then elicited the dose-density curve with autoradiography. There is a linear relationship between density and absorbed dose within the range of 0-68.84mGy. So the absorbed dose from the radiaoactive filter paper in non tissue-equivalent medium could be calculated inversely: the absorbed dose rate from 1MBq/cm2 radiaoactive filter paper on the other side of glass bottom of the culture bottle is 21.9 cGy/h. The method is simple and can be used to inspect the radio-uniformity of radioactive filter paper at the same time.  
        关键词：β-rays;32P;Absorbed dose;Autoradiography   
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        发布时间：2021-03-12
      • SUN Punan
        Issue 11, (2003)
        摘要：A meter for measuring water ratio in petroleum at Worksite 18 described, Which is on the principle of attenuation law of γ-ray intensity in material. Principle, instrument, model of temperature compensation, main technological parameters, and a measurement record at worksite are introduced. Having integrated the detector with a single chip micro controller the meter can output industrial standard signals of 4-20mA, and be used conveniently. At present 18 meters have been applied in Daqing oil field.  
        关键词：γ-ray;Nal scintillation detector;Water ratio in petroleum;Integrated intelligent meter   
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        发布时间：2021-03-12
      • LI Guisheng ZHANG Tianmei SU Youwu LI Shuwei
        Issue 11, (2003)
        摘要：The possibility of using 209Bi as a new threshold detector to measure high-energy neutrons was explored. Fluence rate, energy spectrum and dose equivalent rate distributions for the emitted neutrons in the heavy ion target area were measured by a detector complex of 115In, 27A1, 19F, 12C and 209Bi.  
        关键词：Threshold detector;Experimental verification;Neutron spectrum;Dose equivalent rate   
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        发布时间：2021-03-12
      • ZUOChuantao LIN Xiangtong GUANYihui ZHAO Jun WANG Jian
        Issue 11, (2003)
        摘要：The methodology of PET image remote transfer by Internet has been explored. The original images were acquisited with ECAT EXACT HR+ PET, and then converted to Dicom format by Mview software. The Dicom images were transferred via Internet. Thus the PET images were transferred via Internet successfully. The ideal images were obtained away from 8 km. The transfer time of brain and whole body image was (37±3) s and (245±10) s respectively, while the transfer rate was (34.7±2.8)kbyte/s and (34.4±1.5)kbyte/s, respectively. The results showed that the remote transfer via Internet was feasible and practical.  
        关键词：Internet;Positron emission tomography;Remote transfer   
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        发布时间：2021-03-12
      • LAI Wanchang GE Liangquan WU Yongpeng LIN Yanchang XIAO Gangyi
        Issue 11, (2003)
        摘要：This paper introduces a high sensitive portable X-ray fluorescence analyzer. It is composed of a Si-PIN X-ray detector with thermo-electrical cooler, radio isotope sources and a 2048-channel MCA based on PC/104 computer. The analyzer is about 3.8 kg weight, 30 cm × 28 cm × 14 cm size. The resolution (FWHM) for the 5.9 keV peak of 55Fe is less than 160 eV. The analytical detection limits are about 10μg · g-1 for Cu, Zn, As and other mineral elements. This analyzer can be used to in-situ determine multi-element concentration on natural rock, soil and other mineral products.  
        关键词：Portable XRF analyzer;On-the-spot analysis;X-ray;Si-PIN detector   
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        发布时间：2021-03-12
      • SHEN Xiuzhong YANG Xiuzhou YU Ping’an
        Issue 11, (2003)
        摘要：A physical and thermohydraulic general estimate for the core of 25MW Lead Cooled Fast Breeder Reactor (LCFBR) has been carried out. The estimated result was compared with that of Sodium Cooled Fast Breeder Reactor (SCFBR) at the same power. The preliminary analysis showed that the LCFBR was a safe and feasible fast breeder reactor.  
        关键词：Fast breeder reactor;Lead coolant;Preliminary design   
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        发布时间：2021-03-12
      • QIU Jiuzi
        Issue 11, (2003)
        摘要：The cross sections for 58Ni(n,p)58m+gCo reaction have been measured by using the activation method in the neutron energy range of 13.64 to 14.8 MeV. The 27Al(n,a)24Na reaction was used to monitor the d-T neutron fluence in the target samples. The neutron energies were determined by using a Si(Au) barrier semiconductor detector.  
          
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        发布时间：2021-03-12
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