Preparation and biodistribution of <sup>99</sup>Tc<sup>m</sup> mixed ligand complexes containing a tridentate N-（o-methylthiophenyl）-β-mercaptoacetamide and monodentate thiols

DUAN Xinhong LUGongxu WANG Xuebin

doi:null

您当前的位置：

首页 >

文章列表页 >

Preparation and biodistribution of ⁹⁹Tc^m mixed ligand complexes containing a tridentate N-（o-methylthiophenyl）-β-mercaptoacetamide and monodentate thiols

更新时间：2021-03-12

- Preparation and biodistribution of ⁹⁹Tc^m mixed ligand complexes containing a tridentate N-（o-methylthiophenyl）-β-mercaptoacetamide and monodentate thiols
- NUCLEAR TECHNIQUES Issue 11, (2003)
- 作者机构：
  
  1. 北京林业大学基础科学与技术学院
  2. 北京师范大学化学系,北京,100083
  3. ,北京,100875
- 作者简介：
- 基金信息：
- DOI：
  CLC： TQ421.7
- Published：01 November 2003
- 稿件说明：
移动端阅览
[1]段新红,吕恭序,王学斌.~(99)Tc~m标记的邻甲硫基-N-β-巯基乙酰苯胺和硫醇混配复合物的制备及生物分布研究[J].核技术,2003(11):863-867.

DUAN Xinhong LUGongxu WANG Xuebin. Preparation and biodistribution of ⁹⁹Tc^m mixed ligand complexes containing a tridentate N-（o-methylthiophenyl）-β-mercaptoacetamide and monodentate thiols[J]. Nuclear techniques, 2003, (11): 863-867.
[1]段新红,吕恭序,王学斌.~(99)Tc~m标记的邻甲硫基-N-β-巯基乙酰苯胺和硫醇混配复合物的制备及生物分布研究[J].核技术,2003(11):863-867. DOI：

DUAN Xinhong LUGongxu WANG Xuebin. Preparation and biodistribution of ⁹⁹Tc^m mixed ligand complexes containing a tridentate N-（o-methylthiophenyl）-β-mercaptoacetamide and monodentate thiols[J]. Nuclear techniques, 2003, (11): 863-867. DOI：

摘要

合成了新的三配位体邻甲硫基-N-β-巯基乙酰苯胺（MTPMA）

其结构经红外光谱（IR）、核磁共振（HNMR）、质谱（Ms（FAB+））和元素分析确认。用配体交换方法制备了两种混合配位体复合物99Tcm（L3

L1a）和99Tcm（L3

L1b）。其中

L3为三配位体

L1a、L1b分别为单配位体乙硫醇和异丙硫醇。确定了这两种混配复合物的最佳标记条件

在此条件下

放射化学纯度（RCP）>90％

并且在室温下稳定6 h以上。99Tcm（L3

L1a）和99Tcm（L3

L1b）的小鼠生物分布研究表明:两种混配复合物都可通过正常的血脑屏障

并在脑中有一定滞留。

Abstract

A novel compond

N-(o-methylthiophenyl)-β-mercaptoacetamide (MTPMA)

as a tridentate ligand

was synthesized and characterized by IR

1HNMR

MS(FAB+) and elemental analysis. Two 99Tcm mixed-ligand complexes of 99Tcm (L3

L1a) and 99Tcm (L3

L1b) were produced by ligand exchange reaction. At the same time

the optimized conditions for labelling were obtained. At these conditions

the radiochemical purity of both complexes was better than 90% and they were stable over 6 h at room temperature. Biodistribution study showed that both complexes can penetrate the blood-brain barrier and exhibit retention in mice’s brain .

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Preparation of ¹³¹I-BmK CT and bio-distribution and imaging in glioma-bearing rats

ICP-MS analysis for TiO₂ distribution in mice injected with 3 nm TiO₂ particles

Biodistribution analysis of ¹²⁵I-albumin-IFN-alpha2b fusion protein in rats

Preparation and biodistribution of ⁹⁹Tc^m-GHSA-IFNα2b

Preparation of dopamine D2 receptor imaging agent ¹⁸F-Fallypride and biodistribution study in mice

Related Author

QIAO Wenli1 ZHAO Jinhua1 SHAO Xiaoxia2 ZHANG zhiyong3 LIU Xingfeng3 WANG Taisong1 JIN Wenya1 YAO Yuping1 1

赵晋华

邵晓霞

张志勇

刘兴峰

汪太松

金文雅

姚玉平

Related Institution

同济大学蛋白质研究所

上海欣科医药有限公司

Department of Nuclear Medicine,The First People’s Hospital,Shanghai Jiaotong University,Shanghai 200080,China) 2

中国科学院研究生院

江西中医学院

AI问答

Address：2019 Jialuo Road, Jiading, Shanghai, China Postal code：201800
Tel：021-39194977 Email：LHB@sinap.ac.cn
Technical support is provided by Beijing Founder electronics co., LTD 沪ICP备05005479号-1 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.
Total Visits：881003 Visits Today：530

⁰

Preparation and biodistribution of 99Tcm mixed ligand complexes containing a tridentate N-（o-methylthiophenyl）-β-mercaptoacetamide and monodentate thiols

DOI：

摘要

Abstract

关键词

Keywords

references

Preparation and biodistribution of ⁹⁹Tc^m mixed ligand complexes containing a tridentate N-（o-methylthiophenyl）-β-mercaptoacetamide and monodentate thiols