Using self-designed automatic extraction software of brain functional area

the grey scale distribution of 18F-FDG imaging and the relationship between the 18F-FDG accumulation of brain anatomic function area and the 18F-FDG injected dose

the level of glucose

the age

etc.

were studied. According to the Talairach coordinate system

after rotation

drift and plastic deformation

the 18F-FDG PET imaging was registered into the Talairach coordinate atlas

and then the average gray value scale ratios between individual brain anatomic functional area and whole brain area was calculated. Further more the statistics of the relationship between the I8F-FDG accumulation of every brain anatomic function area and the I8F-FDG injected dose

the level of glucose and the age were tested by using multiple stepwise regression model. After images’ registration

smoothing and extraction

main cerebral cortex of the 18F-FDG PET brain imaging can be successfully localized and extracted

such as frontal lobe

parietal lobe

occipital lobe

temporal lobe

cerebellum

brain ventricle

thalamus and hippocampus. The average ratios to the inner reference of every brain anatomic functional area were 1.01 ± 0.15. By multiple stepwise regresion with the exception of thalamus and hippocampus

the grey scale of all the brain functional area was negatively correlated to the ages

but with no correlation to blood sugar and dose in all areas. To the I8F-FDG PET imaging

the brain functional area extraction program could automatically delineate most of the cerebral cortical area

and also successfully reflect the brain blood and metabolic study

but extraction of the more detailed area needs further investigation.